Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

This package provides tools for storing and managing competition results. Competition is understood as a set of games in which players gain some abstract scores. There are two ways for storing results: in long (one row per game-player) and wide (one row per game with fixed amount of players) formats. This package provides functions for creation and conversion between them. Also there are functions for computing their summary and Head-to-Head values for players. They leverage grammar of data manipulation from dplyr'.

Solves multivariate least squares (MLS) problems subject to constraints on the coefficients, e.g., non-negativity, orthogonality, equality, inequality, monotonicity, unimodality, smoothness, etc. Includes flexible functions for solving MLS problems subject to user-specified equality and/or inequality constraints, as well as a wrapper function that implements 24 common constraint options. Also does k-fold or generalized cross-validation to tune constraint options for MLS problems. See ten Berge (1993, ISBN:9789066950832) for an overview of MLS problems, and see Goldfarb and Idnani (1983) <doi:10.1007/BF02591962> for a discussion of the underlying quadratic programming algorithm.

Analyze and compare conversations using various similarity measures including topic, lexical, semantic, structural, stylistic, sentiment, participant, and timing similarities. Supports both pairwise conversation comparisons and analysis of multiple dyads. Methods are based on established research: Topic modeling: Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>; Landauer et al. (1998) <doi:10.1080/01638539809545028>; Lexical similarity: Jaccard (1912) <doi:10.1111/j.1469-8137.1912.tb05611.x>; Semantic similarity: Salton & Buckley (1988) <doi:10.1016/0306-4573(88)90021-0>; Mikolov et al. (2013) <doi:10.48550/arXiv.1301.3781>; Pennington et al. (2014) <doi:10.3115/v1/D14-1162>; Structural and stylistic analysis: Graesser et al. (2004) <doi:10.1075/target.21131.ryu>; Sentiment analysis: Rinker (2019) <https://github.com/trinker/sentimentr>.

This package provides a suite of computer model test functions that can be used to test and evaluate algorithms for Bayesian (also known as sequential) optimization. Some of the functions have known functional forms, however, most are intended to serve as black-box functions where evaluation requires running computer code that reveals little about the functional forms of the objective and/or constraints. The primary goal of the package is to provide users (especially those who do not have access to real computer models) a source of reproducible and shareable examples that can be used for benchmarking algorithms. The package is a living repository, and so more functions will be added over time. For function suggestions, please do contact the author of the package.

This package provides tools to process CBASS-derived PAM data efficiently. Minimal requirements are PAM-based photosynthetic efficiency data (or data from any other continuous variable that changes with temperature, e.g. relative bleaching scores) from 4 coral samples (nubbins) subjected to 4 temperature profiles of at least 2 colonies from 1 coral species from 1 site. Please refer to the following CBASS (Coral Bleaching Automated Stress System) papers for in-depth information regarding CBASS acute thermal stress assays, experimental design considerations, and ED5/ED50/ED95 thermal parameters: Nicolas R. Evensen et al. (2023) <doi:10.1002/lom3.10555> Christian R. Voolstra et al. (2020) <doi:10.1111/gcb.15148> Christian R. Voolstra et al. (2025) <doi:10.1146/annurev-marine-032223-024511>.

An interface for creating, registering, and resolving content-based identifiers for data management. Content-based identifiers rely on the cryptographic hashes to refer to the files they identify, thus, anyone possessing the file can compute the identifier using a well-known standard algorithm, such as SHA256'. By registering a URL at which the content is accessible to a public archive (such as Hash Archive) or depositing data in a scientific repository such Zenodo', DataONE or SoftwareHeritage', the content identifier can serve many functions typically associated with A Digital Object Identifier ('DOI'). Unlike location-based identifiers like DOIs', content-based identifiers permit the same content to be registered in many locations.

The cito package provides a user-friendly interface for training and interpreting deep neural networks (DNN). cito simplifies the fitting of DNNs by supporting the familiar formula syntax, hyperparameter tuning under cross-validation, and helps to detect and handle convergence problems. DNNs can be trained on CPU, GPU and MacOS GPUs. In addition, cito has many downstream functionalities such as various explainable AI (xAI) metrics (e.g. variable importance, partial dependence plots, accumulated local effect plots, and effect estimates) to interpret trained DNNs. cito optionally provides confidence intervals (and p-values) for all xAI metrics and predictions. At the same time, cito is computationally efficient because it is based on the deep learning framework torch'. The torch package is native to R, so no Python installation or other API is required for this package.

The Large Language Model (LLM) represents a groundbreaking advancement in data science and programming, and also allows us to extend the world of R. A seamless interface for integrating the OpenAI Web APIs into R is provided in this package. This package leverages LLM-based AI techniques, enabling efficient knowledge discovery and data analysis. The previous functions such as seamless translation and image generation have been moved to other packages deepRstudio and stableDiffusion4R'.

Simulates the composition of samples of vegetation according to gradient-based vegetation theory. Features a flexible algorithm incorporating competition and complex multi-gradient interaction.

Perform additional multiple testing procedure methods to p.adjust(), such as weighted Hochberg (Tamhane, A. C., & Liu, L., 2008) <doi:10.1093/biomet/asn018>, ICC adjusted Bonferroni method (Shi, Q., Pavey, E. S., & Carter, R. E., 2012) <doi:10.1002/pst.1514> and a new correlation corrected weighted Hochberg for correlated endpoints.

This package provides tools for Delphi's COVIDcast Epidata API: data access, maps and time series plotting, and basic signal processing. The API includes a collection of numerous indicators relevant to the COVID-19 pandemic in the United States, including official reports, de-identified aggregated medical claims data, large-scale surveys of symptoms and public behavior, and mobility data, typically updated daily and at the county level. All data sources are documented at <https://cmu-delphi.github.io/delphi-epidata/api/covidcast.html>.

This package provides functions to perform matching algorithms for causal inference with clustered data, as described in B. Arpino and M. Cannas (2016) <doi:10.1002/sim.6880>. Pure within-cluster and preferential within-cluster matching are implemented. Both algorithms provide causal estimates with cluster-adjusted estimates of standard errors.

Intended to analyse recordings from multiple microphones (e.g., backpack microphones in captive setting). It allows users to align recordings even if there is non-linear drift of several minutes between them. A call detection and assignment pipeline can be used to find vocalisations and assign them to the vocalising individuals (even if the vocalisation is picked up on multiple microphones). The tracing and measurement functions allow for detailed analysis of the vocalisations and filtering of noise. Finally, the package includes a function to run spectrographic cross correlation, which can be used to compare vocalisations. It also includes multiple other functions related to analysis of vocal behaviour.

Implementation of the Control Polygon Reduction and Control Net Reduction methods for finding parsimonious B-spline regression models.

This package provides a pair of functions for renaming and encoding data frames using external crosswalk files. It is especially useful when constructing master data sets from multiple smaller data sets that do not name or encode variables consistently across files. Based on similar commands in Stata'.

This package provides estimates of several summary measures for clinical trials including the average hazard ratio, the weighted average hazard ratio, the restricted superiority probability ratio, the restricted mean survival difference and the ratio of restricted mean times lost, based on the short-term and long-term hazard ratio model (Yang, 2005 <doi:10.1093/biomet/92.1.1>) which accommodates various non-proportional hazards scenarios. The inference procedures and the asymptotic results for the summary measures are discussed in Yang (2018, <doi:10.1002/sim.7676>).

This package contains the CONCOR (CONvergence of iterated CORrelations) algorithm and a series of supplemental functions for easy running, plotting, and blockmodeling. The CONCOR algorithm is used on social network data to identify network positions based off a definition of structural equivalence; see Breiger, Boorman, and Arabie (1975) <doi:10.1016/0022-2496(75)90028-0> and Wasserman and Faust's book Social Network Analysis: Methods and Applications (1994). This version allows multiple relationships for the same set of nodes and uses both incoming and outgoing ties to find positions.

This package provides similar functionality to Microsoft Excel CUMPRINC function <https://support.microsoft.com/en-us/office/cumprinc-function-94a4516d-bd65-41a1-bc16-053a6af4c04d>. Returns principal remaining at a given month, principal paid in a month, and accumulated principal paid at a given month based on original loan amount, monthly interest rate, and term of loan.

Uses the CMS application programming interface <https://dnav.cms.gov/api/healthdata> to provide users databases containing yearly Medicare reimbursement rates in the United States. Data can be acquired for the entire United States or only for specific localities. Currently, support is only provided for the Medicare Physician Fee Schedule, but support will be expanded for other CMS databases in future versions.

Cluster analysis is performed using pairwise distance information and a random partition distribution. The method is implemented for two random partition distributions. It draws samples and then obtains and plots clustering estimates. An implementation of a selection algorithm is provided for the mass parameter of the partition distribution. Since pairwise distances are the principal input to this procedure, it is most comparable to the hierarchical and k-medoids clustering methods. The method is Dahl, Andros, Carter (2022+) <doi:10.1002/sam.11602>.

The implementation of bias-corrected sandwich variance estimators for the analysis of cluster randomized trials with time-to-event outcomes using the marginal Cox model, proposed by Wang et al. (under review).

This package provides a minimal interface for applying annotators from the Stanford CoreNLP java library. Methods are provided for tasks such as tokenisation, part of speech tagging, lemmatisation, named entity recognition, coreference detection and sentiment analysis.

This package performs Correlated Meta-Analysis ('corrmeta') across multiple OMIC scans, accounting for hidden non-independencies between elements of the scans due to overlapping samples, related samples, or other information. For more information about the method, refer to the paper Province MA. (2013) <doi:10.1142/9789814447973_0023>.