Select balanced and spatially balanced probability samples in multi-dimensional spaces with any prescribed inclusion probabilities. It contains fast (C++ via Rcpp) implementations of the included sampling methods. The local pivotal method by Grafström, Lundström and Schelin (2012) <doi:10.1111/j.1541-0420.2011.01699.x> and spatially correlated Poisson sampling by Grafström (2012) <doi:10.1016/j.jspi.2011.07.003> are included. Also the cube method (for balanced sampling) and the local cube method (for doubly balanced sampling) are included, see Grafström and Tillé (2013) <doi:10.1002/env.2194>.

This package provides a collection of functions to analyse, visualize and interpret wind data and to calculate the potential energy production of wind turbines.

Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). A higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.

Bayes factors and posterior probabilities in Linear models, aimed at provide a formal Bayesian answer to testing and variable selection problems.

This package performs logistic regression for binary longitudinal data, allowing for serial dependence among observations from a given individual and a random intercept term. Estimation is via maximization of the exact likelihood of a suitably defined model. Missing values and unbalanced data are allowed, with some restrictions. M. Helena Goncalves et al.(2007) <DOI: 10.18637/jss.v046.i09>.

Datasets and functions for the book "Initiation à la Statistique avec R", F. Bertrand and M. Maumy-Bertrand (2022, ISBN:978-2100782826 Dunod, fourth edition).

Package providing a number of functions for working with Two- and Four-parameter Beta and closely related distributions (i.e., the Gamma- Binomial-, and Beta-Binomial distributions). Includes, among other things: - d/p/q/r functions for Four-Parameter Beta distributions and Generalized "Binomial" (continuous) distributions, and d/p/r- functions for Beta- Binomial distributions. - d/p/q/r functions for Two- and Four-Parameter Beta distributions parameterized in terms of their means and variances rather than their shape-parameters. - Moment generating functions for Binomial distributions, Beta-Binomial distributions, and observed value distributions. - Functions for estimating classification accuracy and consistency, making use of the Classical Test-Theory based Livingston and Lewis (L&L) and Hanson and Brennan approaches. A shiny app is available, providing a GUI for the L&L approach when used for binary classifications. For url to the app, see documentation for the LL.CA() function. Livingston and Lewis (1995) <doi:10.1111/j.1745-3984.1995.tb00462.x>. Lord (1965) <doi:10.1007/BF02289490>. Hanson (1991) <https://files.eric.ed.gov/fulltext/ED344945.pdf>.

Reads and plots phylogenetic placements.

Bayesian analysis of multivariate receptor modeling. The package consists of implementations of the methods of Park and Oh (2015) <doi:10.1016/j.chemolab.2015.08.021>.The package uses JAGS'(Just Another Gibbs Sampler) to generate Markov chain Monte Carlo samples of parameters.

This package provides comprehensive tools for blinded sample size re-estimation (BSSR) in two-arm clinical trials with binary endpoints. Unlike traditional fixed-sample designs, BSSR allows adaptive sample size adjustments during trials while maintaining statistical integrity and study blinding. Implements five exact statistical tests: Pearson chi-squared, Fisher exact, Fisher mid-p, Z-pooled exact unconditional, and Boschloo exact unconditional tests. Supports restricted, unrestricted, and weighted BSSR approaches with exact Type I error control. Statistical methods based on Mehrotra et al. (2003) <doi:10.1111/1541-0420.00051> and Kieser (2020) <doi:10.1007/978-3-030-49528-2_21>.

This package implements biplot (2d and 3d) of multivariate data based on principal components analysis and diagnostic tools of the quality of the reduction.

This package provides tools and code snippets for summarizing nested data, adverse events and REDCap study information.

Allows to view the optimal probability cut-off point at which the Sensitivity and Specificity meets and its a best way to minimize both Type-1 and Type-2 error for a binary Classifier in determining the Probability threshold.

Whole-genome regression methods on Bayesian framework fitted via EM or Gibbs sampling, single step (<doi:10.1534/g3.119.400728>), univariate and multivariate (<doi:10.1186/s12711-022-00730-w>, <doi:10.1093/genetics/iyae179>), with optional kernel term and sampling techniques (<doi:10.1186/s12859-017-1582-3>).

Objective Bayesian inference procedures for the parameters of the multivariate random effects model with application to multivariate meta-analysis. The posterior for the model parameters, namely the overall mean vector and the between-study covariance matrix, are assessed by constructing Markov chains based on the Metropolis-Hastings algorithms as developed in Bodnar and Bodnar (2021) (<arXiv:2104.02105>). The Metropolis-Hastings algorithm is designed under the assumption of the normal distribution and the t-distribution when the Berger and Bernardo reference prior and the Jeffreys prior are assigned to the model parameters. Convergence properties of the generated Markov chains are investigated by the rank plots and the split hat-R estimate based on the rank normalization, which are proposed in Vehtari et al. (2021) (<DOI:10.1214/20-BA1221>).

Fits Cox model via stochastic gradient descent. This implementation avoids computational instability of the standard Cox Model when dealing large datasets. Furthermore, it scales up with large datasets that do not fit the memory. It also handles large sparse datasets using proximal stochastic gradient descent algorithm. For more details about the method, please see Aliasghar Tarkhan and Noah Simon (2020) <arXiv:2003.00116v2>.

Bayesian approaches for analyzing multivariate data in ecology. Estimation is performed using Markov Chain Monte Carlo (MCMC) methods via Three. JAGS types of models may be fitted: 1) With explanatory variables only, boral fits independent column Generalized Linear Models (GLMs) to each column of the response matrix; 2) With latent variables only, boral fits a purely latent variable model for model-based unconstrained ordination; 3) With explanatory and latent variables, boral fits correlated column GLMs with latent variables to account for any residual correlation between the columns of the response matrix.

Inflammation can affect many micronutrient biomarkers and can thus lead to incorrect diagnosis of individuals and to over- or under-estimate the prevalence of deficiency in a population. Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) is a multi-agency and multi-country partnership designed to improve the interpretation of nutrient biomarkers in settings of inflammation and to generate context-specific estimates of risk factors for anemia (Suchdev (2016) <doi:10.3945/an.115.010215>). In the past few years, BRINDA published a series of papers to provide guidance on how to adjust micronutrient biomarkers, retinol binding protein, serum retinol, serum ferritin by Namaste (2020), soluble transferrin receptor (sTfR), serum zinc, serum and Red Blood Cell (RBC) folate, and serum B-12, using inflammation markers, alpha-1-acid glycoprotein (AGP) and/or C-Reactive Protein (CRP) by Namaste (2020) <doi:10.1093/ajcn/nqaa141>, Rohner (2017) <doi:10.3945/ajcn.116.142232>, McDonald (2020) <doi:10.1093/ajcn/nqz304>, and Young (2020) <doi:10.1093/ajcn/nqz303>. The BRINDA inflammation adjustment method mainly focuses on Women of Reproductive Age (WRA) and Preschool-age Children (PSC); however, the general principle of the BRINDA method might apply to other population groups. The BRINDA R package is a user-friendly all-in-one R package that uses a series of functions to implement BRINDA adjustment method, as described above. The BRINDA R package will first carry out rigorous checks and provides users guidance to correct data or input errors (if they occur) prior to inflammation adjustments. After no errors are detected, the package implements the BRINDA inflammation adjustment for up to five micronutrient biomarkers, namely retinol-binding-protein, serum retinol, serum ferritin, sTfR, and serum zinc (when appropriate), using inflammation indicators of AGP and/or CRP for various population groups. Of note, adjustment for serum and RBC folate and serum B-12 is not included in the R package, since evidence shows that no adjustment is needed for these micronutrient biomarkers in either WRA or PSC groups (Young (2020) <doi:10.1093/ajcn/nqz303>).

Fully Bayesian inference for estimating the number of clusters and related parameters to heterogeneous binary data.

Following Arroyo-Maté-Roque (2006), the function calculates the distance between rows or columns of the dataset using the generalized Minkowski metric as described by Ichino-Yaguchi (1994). The distance measure gives more weight to differences between quartiles than to differences between extremes, making it less sensitive to outliers. Further,the function calculates the silhouette width (Rousseeuw 1987) for different numbers of clusters and selects the number of clusters that maximizes the average silhouette width, unless a specific number of clusters is provided by the user. The approach implemented in this package is based on the following publications: Rousseeuw (1987) <doi:10.1016/0377-0427(87)90125-7>; Ichino-Yaguchi (1994) <doi:10.1109/21.286391>; Arroyo-Maté-Roque (2006) <doi:10.1007/3-540-34416-0_7>.

Implement in R interactive Circos-like visualizations of genomic data, to map information such as genetic variants, genomic fusions and aberrations to a circular genome, as proposed by the JavaScript library BioCircos.js', based on the JQuery and D3 technologies. The output is by default displayed in stand-alone HTML documents or in the RStudio viewer pane. Moreover it can be integrated in R Markdown documents and Shiny applications.

Our recently developed fully robust Bayesian semiparametric mixed-effect model for high-dimensional longitudinal studies with heterogeneous observations can be implemented through this package. This model can distinguish between time-varying interactions and constant-effect-only cases to avoid model misspecifications. Facilitated by spike-and-slab priors, this model leads to superior performance in estimation, identification and statistical inference. In particular, robust Bayesian inferences in terms of valid Bayesian credible intervals on both parametric and nonparametric effects can be validated on finite samples. The Markov chain Monte Carlo algorithms of the proposed and alternative models are efficiently implemented in C++'.

Companion package, functions, data sets, examples for the book Patrice Bertail and Anna Dudek (2025), Bootstrap for Dependent Data, with an R package (by Bernard Desgraupes and Karolina Marek) - submitted. Kreiss, J.-P. and Paparoditis, E. (2003) <doi:10.1214/aos/1074290332> Politis, D.N., and White, H. (2004) <doi:10.1081/ETC-120028836> Patton, A., Politis, D.N., and White, H. (2009) <doi:10.1080/07474930802459016> Tsybakov, A. B. (2018) <doi:10.1007/b13794> Bickel, P., and Sakov, A. (2008) <doi:10.1214/18-AOS1803> Götze, F. and RaÄ kauskas, A. (2001) <doi:10.1214/lnms/1215090074> Politis, D. N., Romano, J. P., & Wolf, M. (1999, ISBN:978-0-387-98854-2) Carlstein E. (1986) <doi:10.1214/aos/1176350057> Künsch, H. (1989) <doi:10.1214/aos/1176347265> Liu, R. and Singh, K. (1992) <https://www.stat.purdue.edu/docs/research/tech-reports/1991/tr91-07.pdf> Politis, D.N. and Romano, J.P. (1994) <doi:10.1080/01621459.1994.10476870> Politis, D.N. and Romano, J.P. (1992) <https://www.stat.purdue.edu/docs/research/tech-reports/1991/tr91-07.pdf> Patrice Bertail, Anna E. Dudek. (2022) <doi:10.3150/23-BEJ1683> Dudek, A.E., LeÅ kow, J., Paparoditis, E. and Politis, D. (2014a) <https://ideas.repec.org/a/bla/jtsera/v35y2014i2p89-114.html> Beran, R. (1997) <doi:10.1023/A:1003114420352> B. Efron, and Tibshirani, R. (1993, ISBN:9780429246593) Bickel, P. J., Götze, F. and van Zwet, W. R. (1997) <doi:10.1007/978-1-4614-1314-1_17> A. C. Davison, D. Hinkley (1997) <doi:10.2307/1271471> Falk, M., & Reiss, R. D. (1989) <doi:10.1007/BF00354758> Lahiri, S. N. (2003) <doi:10.1007/978-1-4757-3803-2> Shimizu, K. .(2017) <doi:10.1007/978-3-8348-9778-7> Park, J.Y. (2003) <doi:10.1111/1468-0262.00471> Kirch, C. and Politis, D. N. (2011) <doi:10.48550/arXiv.1211.4732> Bertail, P. and Dudek, A.E. (2024) <doi:10.3150/23-BEJ1683> Dudek, A. E. (2015) <doi:10.1007/s00184-014-0505-9> Dudek, A. E. (2018) <doi:10.1080/10485252.2017.1404060> Bertail, P., Clémençon, S. (2006a) <https://ideas.repec.org/p/crs/wpaper/2004-47.html> Bertail, P. and Clémençon, S. (2006, ISBN:978-0-387-36062-1) RaduloviÄ , D. (2006) <doi:10.1007/BF02603005> Bertail, P. Politis, D. N. Rhomari, N. (2000) <doi:10.1080/02331880008802701> Nordman, D.J. Lahiri, S.N.(2004) <doi:10.1214/009053604000000779> Politis, D.N. Romano, J.P. (1993) <doi:10.1006/jmva.1993.1085> Hurvich, C. M. and Zeger, S. L. (1987, ISBN:978-1-4612-0099-4) Bertail, P. and Dudek, A. (2021) <doi:10.1214/20-EJS1787> Bertail, P., Clémençon, S. and Tressou, J. (2015) <doi:10.1111/jtsa.12105> Asmussen, S. (1987) <doi:10.1007/978-3-662-11657-9> Efron, B. (1979) <doi:10.1214/aos/1176344552> Gray, H., Schucany, W. and Watkins, T. (1972) <doi:10.2307/2335521> Quenouille, M.H. (1949) <doi:10.1111/j.2517-6161.1949.tb00023.x> Quenouille, M. H. (1956) <doi:10.2307/2332914> Prakasa Rao, B. L. S. and Kulperger, R. J. (1989) <https://www.jstor.org/stable/25050735> Rajarshi, M.B. (1990) <doi:10.1007/BF00050835> Dudek, A.E. Maiz, S. and Elbadaoui, M. (2014) <doi:10.1016/j.sigpro.2014.04.022> Beran R. (1986) <doi:10.1214/aos/1176349847> Maritz, J. S. and Jarrett, R. G. (1978) <doi:10.2307/2286545> Bertail, P., Politis, D., Romano, J. (1999) <doi:10.2307/2670177> Bertail, P. and Clémençon, S. (2006b) <doi:10.1007/0-387-36062-X_1> RaduloviÄ , D. (2004) <doi:10.1007/BF02603005> Hurd, H.L., Miamee, A.G. (2007) <doi:10.1002/9780470182833> Bühlmann, P. (1997) <doi:10.2307/3318584> Choi, E., Hall, P. (2000) <doi:10.1111/1467-9868.00244> Efron, B., Tibshirani, R. (1993, ISBN:9780429246593) Bertail, P., Clémençon, S. and Tressou, J. (2009) <doi:10.1007/s10687-009-0081-y> Bertail, P., Medina-Garay, A., De Lima-Medina, F. and Jales, I. (2024) <doi:10.1080/02331888.2024.2344670>.

Response surface methods for drug synergy analysis. Available methods include generalized and classical Loewe formulations as well as Highest Single Agent methodology. Response surfaces can be plotted in an interactive 3-D plot and formal statistical tests for presence of synergistic effects are available. Implemented methods and tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) <doi:10.1038/s41598-017-18068-5>.