This package provides functions for hormesis screening by classifying the shapes of dose-response curves based on semiparametric tests. The shapes are indications of different potential toxicology effect. It also offers a scalable visualization scheme to present testing conclusions for large-scale dataset with a large number of dose-response curves. For more information, see Jin et al. (2026) <https://github.com/YinglJin-0203/shorm/blob/main/Manuscripts/BotanicalHormesisTestingFinalDraft.docx>.

Fast Multiplication and Marginalization of Sparse Tables <doi:10.18637/jss.v111.i02>.

This package provides a network module-based generalized linear model for differential expression analysis with the count-based sequence data from RNA-Seq.

Estimate networks and causal relationships in complex systems through Structural Equation Modeling. This package also includes functions for importing, weight, manipulate, and fit biological network models within the Structural Equation Modeling framework as outlined in the Supplementary Material of Grassi M, Palluzzi F, Tarantino B (2022) <doi:10.1093/bioinformatics/btac567>.

This package provides a simple to use summary function that can be used with pipes and displays nicely in the console. The default summary statistics may be modified by the user as can the default formatting. Support for data frames and vectors is included, and users can implement their own skim methods for specific object types as described in a vignette. Default summaries include support for inline spark graphs. Instructions for managing these on specific operating systems are given in the "Using skimr" vignette and the README.

This package contains functions and datasets for math taught in school. A main focus is set to prime-calculation.

This package provides tools for performing variable selection in three-way data using N-PLS in combination with L1 penalization, Selectivity Ratio and VIP scores. The N-PLS model (Rasmus Bro, 1996 <DOI:10.1002/(SICI)1099-128X(199601)10:1%3C47::AID-CEM400%3E3.0.CO;2-C>) is the natural extension of PLS (Partial Least Squares) to N-way structures, and tries to maximize the covariance between X and Y data arrays. The package also adds variable selection through L1 penalization, Selectivity Ratio and VIP scores.

This package provides functions for efficiently estimating properties of the Van Genuchten-Mualem model for soil hydraulic parameters from possibly sparse soil water retention and hydraulic conductivity data by multi-response parameter estimation methods (Stewart, W.E., Caracotsios, M. Soerensen, J.P. (1992) "Parameter estimation from multi-response data" <doi:10.1002/aic.690380502>). Parameter estimation is simplified by exploiting the fact that residual and saturated water contents and saturated conductivity are conditionally linear parameters (Bates, D. M. and Watts, D. G. (1988) "Nonlinear Regression Analysis and Its Applications" <doi:10.1002/9780470316757>). Estimated parameters are optionally constrained by the evaporation characteristic length (Lehmann, P., Bickel, S., Wei, Z. and Or, D. (2020) "Physical Constraints for Improved Soil Hydraulic Parameter Estimation by Pedotransfer Functions" <doi:10.1029/2019WR025963>) to ensure that the estimated parameters are physically valid. Common S3 methods and further utility functions allow to process, explore and visualise estimation results.

This package provides a tool for simulating rhythmic data: transcriptome data using Gaussian or negative binomial distributions, and behavioral activity data using Bernoulli or Poisson distributions. See Singer et al. (2019) <doi:10.7717/peerj.6985>.

Calculates and plots the SiZer map for scatterplot data. A SiZer map is a way of examining when the p-th derivative of a scatterplot-smoother is significantly negative, possibly zero or significantly positive across a range of smoothing bandwidths.

Computes clustering by fitting Gaussian mixture models (GMM) via stochastic approximation following the methods of Nguyen and Jones (2018) <doi:10.1201/9780429446177>. It also provides some test data generation and plotting functionality to assist with this process.

Offers a fast algorithm for fitting solution paths of sparse SVM models with lasso or elastic-net regularization. Reference: Congrui Yi and Jian Huang (2017) <doi:10.1080/10618600.2016.1256816>.

This package provides a sparklyr extension package providing an integration with Google BigQuery'. It supports direct import/export where records are directly streamed from/to BigQuery'. In addition, data may be imported/exported via intermediate data extracts on Google Cloud Storage'.

The package is used for calibrating the design parameters for single-to-double arm transition design proposed by Shi and Yin (2017). The calibration is performed via numerical enumeration to find the optimal design that satisfies the constraints on the type I and II error rates.

Three new methods to perform outlier detection in a survival context. In total there are six methods provided, the first three methods are traditional residual-based outlier detection methods, the second three are the concordance-based. Package developed during the work on the two following publications: Pinto J., Carvalho A. and Vinga S. (2015) <doi:10.5220/0005225300750082>; Pinto J.D., Carvalho A.M., Vinga S. (2015) <doi:10.1007/978-3-319-27926-8_22>.

Simple SendGrid Email API client for creating and sending emails. For more information, visit the official SendGrid Email API documentation: <https://sendgrid.com/en-us/solutions/email-api>.

Sensitivity analysis for multiple outcomes in observational studies. For instance, all linear combinations of several outcomes may be explored using Scheffe projections in the comparison() function; see Rosenbaum (2016, Annals of Applied Statistics) <doi:10.1214/16-AOAS942>. Alternatively, attention may focus on a few principal components in the principal() function. The package includes parallel methods for individual outcomes, including tests in the senm() function and confidence intervals in the senmCI() function.

Utility functions for survey-weighted regression, diagnostics, and visualization.

Stress Response score (SRscore) is a stress responsiveness measure for transcriptome datasets and is based on the vote-counting method. The SRscore is determined to evaluate and score genes on the basis of the consistency of the direction of their regulation (Up-regulation, Down-regulation, or No change) under stress conditions across multiple analyzed research projects. This package is based on the HN-score (score based on the ratio of gene expression between hypoxic and normoxic conditions) proposed by Tamura and Bono (2022) <doi:10.3390/life12071079>, and can calculate both the original method and an extended calculation method described in Fukuda et al. (2025) <doi:10.1093/plphys/kiaf105>.

Structural multivariate-univariate linear mixed model solver for estimation of multiple random effects with unknown variance-covariance structures (e.g., heterogeneous and unstructured) and known covariance among levels of random effects (e.g., pedigree and genomic relationship matrices) (Covarrubias-Pazaran, 2016 <doi:10.1371/journal.pone.0156744>; Maier et al., 2015 <doi:10.1016/j.ajhg.2014.12.006>; Jensen et al., 1997). REML estimates can be obtained using the Direct-Inversion Newton-Raphson and Direct-Inversion Average Information algorithms for the problems r x r (r being the number of records) or using the Henderson-based average information algorithm for the problem c x c (c being the number of coefficients to estimate). Spatial models can also be fitted using the two-dimensional spline functionality available.

Cluster-independent method based on topology structure of gene co-expression network for identifying feature gene sets, extracting cellular subpopulations, and elucidating intrinsic relationships among these subpopulations. Without prior cell clustering, SifiNet circumvents potential inaccuracies in clustering that may influence subsequent analyses. This method is introduced in Qi Gao, Zhicheng Ji, Liuyang Wang, Kouros Owzar, Qi-Jing Li, Cliburn Chan, Jichun Xie "SifiNet: a robust and accurate method to identify feature gene sets and annotate cells" (2024) <doi:10.1093/nar/gkae307>.

Combines information from two independent surveys using a model-assisted projection method. Designed for survey sampling scenarios where a large sample collects only auxiliary information (Survey 1) and a smaller sample provides data on both variables of interest and auxiliary variables (Survey 2). Implements a working model to generate synthetic values of the variable of interest by fitting the model to Survey 2 data and predicting values for Survey 1 based on its auxiliary variables (Kim & Rao, 2012) <doi:10.1093/biomet/asr063>.

Calculates the sup MZ value to detect the unknown structural break points under Heteroskedasticity as given in Ahmed et al. (2017) (<DOI: 10.1080/03610926.2016.1235200>).

This implements the Brunton et al (2016; PNAS <doi:10.1073/pnas.1517384113>) sparse identification algorithm for finding ordinary differential equations for a measured system from raw data (SINDy). The package includes a set of additional tools for working with raw data, with an emphasis on cognitive science applications (Dale and Bhat, 2018 <doi:10.1016/j.cogsys.2018.06.020>). See <https://github.com/racdale/sindyr> for examples and updates.