Computes conditional multivariate normal densities, probabilities, and random deviates.

Searches for, accesses, and retrieves Statistics Canada data tables, as well as individual vectors, as tidy data frames. This package enriches the tables with metadata, deals with encoding issues, allows for bilingual English or French language data retrieval, and bundles convenience functions to make it easier to work with retrieved table data. For more efficient data access the package allows for caching data in a local database and database level filtering, data manipulation and summarizing.

Design and evaluate choice-based conjoint survey experiments. Generate a variety of survey designs, including random designs, frequency-based designs, and D-optimal designs, as well as "labeled" designs (also known as "alternative-specific designs"), designs with "no choice" options, and designs with dominant alternatives removed. Conveniently inspect and compare designs using a variety of metrics, including design balance, overlap, and D-error, and simulate choice data for a survey design either randomly or according to a utility model defined by user-provided prior parameters. Conduct a power analysis for a given survey design by estimating the same model on different subsets of the data to simulate different sample sizes. Bayesian D-efficient designs using the cea and modfed methods are obtained using the idefix package by Traets et al (2020) <doi:10.18637/jss.v096.i03>. Choice simulation and model estimation in power analyses are handled using the logitr package by Helveston (2023) <doi:10.18637/jss.v105.i10>.

Access chemical, hazard, bioactivity, and exposure data from the Computational Toxicology and Exposure ('CTX') APIs <https://api-ccte.epa.gov/docs/>. ccdR was developed to streamline the process of accessing the information available through the CTX APIs without requiring prior knowledge of how to use APIs. Most data is also available on the CompTox Chemical Dashboard ('CCD') <https://comptox.epa.gov/dashboard/> and other resources found at the EPA Computational Toxicology and Exposure Online Resources <https://www.epa.gov/comptox-tools>.

Estimates nonlinear causal dose-response functions for continuous treatments using spline-based methods under standard causal assumptions (unconfoundedness / ignorability). Implements three identification strategies: Inverse Probability Weighting (IPW) via the generalised propensity score (GPS), G-computation (outcome regression), and a doubly-robust combination. Natural cubic splines and B-splines are supported for both the exposure-response curve f(T) and the propensity nuisance model. Pointwise confidence bands are obtained via the sandwich estimator or nonparametric bootstrap. Also provides fragility diagnostics including pointwise curvature-based fragility, uncertainty-normalised fragility, and regional integration over user-defined treatment intervals. Builds on the framework of Hirano and Imbens (2004) <doi:10.1111/j.1468-0262.2004.00481.x> for continuous treatments and extends it to fully nonparametric spline estimation.

Many modern C/C++ development tools in the clang toolchain, such as clang-tidy or clangd', rely on the presence of a compilation database in JSON format <https://clang.llvm.org/docs/JSONCompilationDatabase.html>. This package temporarily injects additional build flags into the R build process to generate such a compilation database.

Apply and visualize conditional formatting to data frames in R. It renders a data frame with cells formatted according to criteria defined by rules, using a tidy evaluation syntax. The table is printed either opening a web browser or within the RStudio viewer if available. The conditional formatting rules allow to highlight cells matching a condition or add a gradient background to a given column. This package supports both HTML and LaTeX outputs in knitr reports, and exporting to an xlsx file.

Creation and selection of (Advanced) Coupled Matrix and Tensor Factorization (ACMTF) and ACMTF-Regression (ACMTF-R) models. Selection of the optimal number of components can be done using ACMTF_modelSelection() and ACMTFR_modelSelection()'. The CMTF and ACMTF methods were originally described by Acar et al., 2011 <doi:10.48550/arXiv.1105.3422> and Acar et al., 2014 <doi:10.1186/1471-2105-15-239>, respectively.

The biases introduced in association measures, particularly mutual information, are influenced by factors such as tumor purity, mutation burden, and hypermethylation. This package provides the estimation of conditional mutual information (CMI) and its statistical significance with a focus on its application to multi-omics data. Utilizing B-spline functions (inspired by Daub et al. (2004) <doi:10.1186/1471-2105-5-118>), the package offers tools to estimate the association between heterogeneous multi- omics data, while removing the effects of confounding factors. This helps to unravel complex biological interactions. In addition, it includes methods to evaluate the statistical significance of these associations, providing a robust framework for multi-omics data integration and analysis. This package is ideal for researchers in computational biology, bioinformatics, and systems biology seeking a comprehensive tool for understanding interdependencies in omics data.

This package implements weighted estimation in Cox regression as proposed by Schemper, Wakounig and Heinze (Statistics in Medicine, 2009, <doi:10.1002/sim.3623>) and as described in Dunkler, Ploner, Schemper and Heinze (Journal of Statistical Software, 2018, <doi:10.18637/jss.v084.i02>). Weighted Cox regression provides unbiased average hazard ratio estimates also in case of non-proportional hazards. Approximated generalized concordance probability an effect size measure for clear-cut decisions can be obtained. The package provides options to estimate time-dependent effects conveniently by including interactions of covariates with arbitrary functions of time, with or without making use of the weighting option.

Easily cache and retrieve computation results. The package works seamlessly across interactive R sessions, R scripts and Rmarkdown documents.

This package provides a minimal interface for applying annotators from the Stanford CoreNLP java library. Methods are provided for tasks such as tokenisation, part of speech tagging, lemmatisation, named entity recognition, coreference detection and sentiment analysis.

Interface to the ComexStat API <https://comexstat.mdic.gov.br/> from the Brazilian Ministry of Development, Industry, Trade and Services (MDIC). Provides access to detailed export and import data, including general trade statistics (1997-present), city-level data, historical data (1989-1996), and auxiliary tables with product codes (NCM - Nomenclatura Comum do Mercosul, NBM - Nomenclatura Brasileira de Mercadorias, HS - Harmonized System), countries, economic classifications (CGCE - Classificacao por Grandes Categorias Economicas, SITC - Standard International Trade Classification, ISIC - International Standard Industrial Classification), and other categories. Uses only httr2 for HTTP requests and cli for console messages.

Calculates centrality indices additional to the igraph package centrality functions.

Visualize the connectedness of factors in two-way tables. Perform two-way filtering to improve the degree of connectedness. See Weeks & Williams (1964) <doi:10.1080/00401706.1964.10490188>.

Returns an edit-distance based clusterization of an input vector of strings. Each cluster will contain a set of strings w/ small mutual edit-distance (e.g., Levenshtein, optimum-sequence-alignment, Damerau-Levenshtein), as computed by stringdist::stringdist(). The set of all mutual edit-distances is then used by graph algorithms (from package igraph') to single out subsets of high connectivity.

Collective matrix factorization (CMF) finds joint low-rank representations for a collection of matrices with shared row or column entities. This code learns a variational Bayesian approximation for CMF, supporting multiple likelihood potentials and missing data, while identifying both factors shared by multiple matrices and factors private for each matrix. For further details on the method see Klami et al. (2014) <arXiv:1312.5921>. The package can also be used to learn Bayesian canonical correlation analysis (CCA) and group factor analysis (GFA) models, both of which are special cases of CMF. This is likely to be useful for people looking for CCA and GFA solutions supporting missing data and non-Gaussian likelihoods. See Klami et al. (2013) <https://research.cs.aalto.fi/pml/online-papers/klami13a.pdf> and Virtanen et al. (2012) <http://proceedings.mlr.press/v22/virtanen12.html> for details on Bayesian CCA and GFA, respectively.

Gene Symbols or Ensembl Gene IDs are converted using the Bimap interface in AnnotationDbi in convertId2() but that function is only provided as fallback mechanism for the most common use cases in data analysis. The main function in the package is convert.bm() which queries BioMart using the full capacity of the API provided through the biomaRt package. Presets and defaults are provided for convenience but all "marts", "filters" and "attributes" can be set by the user. Function convert.alias() converts Gene Symbols to Aliases and vice versa and function likely_symbol() attempts to determine the most likely current Gene Symbol.

Enables curving text elements in Shiny apps.

This package performs Bayesian nonparametric density estimation using Martingale posterior distributions including the Copula Resampling (CopRe) algorithm. Also included are a Gibbs sampler for the marginal Gibbs-type mixture model and an extension to include full uncertainty quantification via a predictive sequence resampling (SeqRe) algorithm. The CopRe and SeqRe samplers generate random nonparametric distributions as output, leading to complete nonparametric inference on posterior summaries. Routines for calculating arbitrary functionals from the sampled distributions are included as well as an important algorithm for finding the number and location of modes, which can then be used to estimate the clusters in the data using, for example, k-means. Implements work developed in Moya B., Walker S. G. (2022). <doi:10.48550/arxiv.2206.08418>, Fong, E., Holmes, C., Walker, S. G. (2021) <doi:10.48550/arxiv.2103.15671>, and Escobar M. D., West, M. (1995) <doi:10.1080/01621459.1995.10476550>.

Estimate survival using data mapped to the Observational Medical Outcomes Partnership common data model. Survival can be estimated based on user-defined study cohorts.

Multiple comparison techniques are typically applied following an F test from an ANOVA to decide which means are significantly different from one another. As an alternative to traditional methods, cluster analysis can be performed to group the means of different treatments into non-overlapping clusters. Treatments in different groups are considered statistically different. Several approaches have been proposed, with varying clustering methods and cut-off criteria. This package implements cluster-based multiple comparisons tests and also provides a visual representation in the form of a dendrogram. Di Rienzo, J. A., Guzman, A. W., & Casanoves, F. (2002) <jstor.org/stable/1400690>. Bautista, M. G., Smith, D. W., & Steiner, R. L. (1997) <doi:10.2307/1400402>.

DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. CimpleG is a method for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. CimpleG is time efficient and performs as well as top performing methods for cell-type classification of blood cells and other somatic cells, while basing its prediction on a single DNA methylation site per cell type (but users can also select more sites if they so wish). Users can train cell type classifiers ('CimpleG based, and others) and directly apply these in a deconvolution of cell mixes context. Altogether, CimpleG provides a complete computational framework for the delineation of DNAm signatures and cellular deconvolution. For more details see Maié et al. (2023) <doi:10.1186/s13059-023-03000-0>.

This package provides a generic, easy-to-use and intuitive pharmacokinetic/pharmacodynamic (PK/PD) simulation platform based on the R packages rxode2 and mrgsolve'. Campsis provides an abstraction layer over the underlying processes of defining a PK/PD model, assembling a custom dataset and running a simulation. The package has a strong dependency on the R package campsismod', which allows models to be read from and written to files, including through a JSON-based interface, and to be adapted further on the fly in the R environment. In addition, campsis allows users to assemble datasets in an intuitive manner, including via a JSON-based interface to import Campsis datasets defined using formal JSON schemas distributed with the package. Once the dataset is ready, the package prepares the simulation, calls rxode2 or mrgsolve (at the user's choice), and returns the results for the given model, dataset and desired simulation settings. The package itself is licensed under the GPL (>= 3); the JSON schema files shipped in inst/extdata are licensed separately under the Creative Commons Attribution 4.0 International (CC BY 4.0).