Comprehensive suite of Granger causality tests for time series and panel data. For time series: Toda-Yamamoto (1995) <doi:10.1016/0304-4076(94)01616-8>, Fourier-based tests with single frequency (Enders and Jones, 2016) <doi:10.1515/snde-2014-0101> and cumulative frequencies (Nazlioglu et al., 2019) <doi:10.1080/1540496X.2018.1434072>, quantile causality tests (Cai et al., 2023) <doi:10.1016/j.frl.2023.104327>, and Bootstrap Fourier Granger Causality in Quantiles (Cheng et al., 2021) <doi:10.1007/s12076-020-00263-0>. For panel data: Panel Fourier Toda-Yamamoto (Yilanci and Gorus, 2020) <doi:10.1007/s11356-020-10092-9> and Panel Quantile Causality tests (Wang and Nguyen, 2022) <doi:10.1080/1331677X.2021.1952089>, as well as Group-Mean and Pooled Fully Modified OLS estimators for panel cointegrating polynomial regressions (Wagner and Reichold, 2023) <doi:10.1080/07474938.2023.2178141>. All tests include bootstrap inference for robust p-values.

This package implements a joint cointegration testing approach that combines Engle-Granger, Johansen maximum eigenvalue, Boswijk, and Banerjee tests into a unified test-statistic for the null of non-cointegration. Also see Bayer and Hanck (2013) <doi:10.1111/j.1467-9892.2012.00814.x>.

Is designed to test for association between methylation at CpG sites across the genome and a phenotype of interest, adjusting for any relevant covariates. The package can perform standard analyses of large datasets very quickly with no need to impute the data. It can also handle mixed effects models with chip or batch entering the model as a random intercept. Also includes tools to apply quality control filters, perform permutation tests, and create QQ plots, manhattan plots, and scatterplots for individual CpG sites.

This package provides a likelihood-based hypothesis testing approach is implemented for assessing causal mediation. Described in Millstein, Chen, and Breton (2016), <DOI:10.1093/bioinformatics/btw135>, it could be used to test for mediation of a known causal association between a DNA variant, the instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.

This package provides a device closing function which is able to crop graphics (e.g., PDF, PNG files) on Unix-like operating systems with the required underlying command-line tools installed.

This package implements computationally-efficient construction of confidence intervals from permutation or randomization tests for simple differences in means, based on Nguyen (2009) <doi:10.15760/etd.7798>.

This package provides a general cross-fitting engine for semiparametric estimation (e.g., double/debiased machine learning). Supports user-defined target functionals and directed acyclic graphs of nuisance learners with per-node training fold widths, target-specific evaluation windows, and fold-allocation modes ("overlap", "disjoint", "independence"). Returns either numeric estimates (mode = "estimate") or cross-fitted prediction functions (mode = "predict"), with configurable aggregation over panels and repetitions, reuse-aware caching, and failure isolation, making it well-suited for simulation studies and large benchmarks.

Regression, classification, contour plots, hypothesis testing and fitting of distributions for compositional data are some of the functions included. We further include functions for percentages (or proportions). The standard textbook for such data is John Aitchison's (1986) "The statistical analysis of compositional data". Relevant papers include: a) Tsagris M.T., Preston S. and Wood A.T.A. (2011). "A data--based power transformation for compositional data". Fourth International International Workshop on Compositional Data Analysis. <doi:10.48550/arXiv.1106.1451>. b) Tsagris M. (2014). "The k--NN algorithm for compositional data: a revised approach with and without zero values present". Journal of Data Science, 12(3): 519--534. <doi:10.6339/JDS.201407_12(3).0008>. c) Tsagris M. (2015). "A novel, divergence based, regression for compositional data". Proceedings of the 28th Panhellenic Statistics Conference, 15-18 April 2015, Athens, Greece, 430--444. <doi:10.48550/arXiv.1511.07600>. d) Tsagris M. (2015). "Regression analysis with compositional data containing zero values". Chilean Journal of Statistics, 6(2): 47--57. <https://soche.cl/chjs/volumes/06/02/Tsagris(2015).pdf>. e) Tsagris M., Preston S. and Wood A.T.A. (2016). "Improved supervised classification for compositional data using the alpha-transformation". Journal of Classification, 33(2): 243--261. <doi:10.1007/s00357-016-9207-5>. f) Tsagris M., Preston S. and Wood A.T.A. (2017). "Nonparametric hypothesis testing for equality of means on the simplex". Journal of Statistical Computation and Simulation, 87(2): 406--422. <doi:10.1080/00949655.2016.1216554>. g) Tsagris M. and Stewart C. (2018). "A Dirichlet regression model for compositional data with zeros". Lobachevskii Journal of Mathematics, 39(3): 398--412. <doi:10.1134/S1995080218030198>. h) Alenazi A. (2019). "Regression for compositional data with compositional data as predictor variables with or without zero values". Journal of Data Science, 17(1): 219--238. <doi:10.6339/JDS.201901_17(1).0010>. i) Tsagris M. and Stewart C. (2020). "A folded model for compositional data analysis". Australian and New Zealand Journal of Statistics, 62(2): 249--277. <doi:10.1111/anzs.12289>. j) Alenazi A.A. (2022). "f--divergence regression models for compositional data". Pakistan Journal of Statistics and Operation Research, 18(4): 867--882. <doi:10.18187/pjsor.v18i4.3969>. k) Tsagris M. and Stewart C. (2022). "A Review of Flexible Transformations for Modeling Compositional Data". In Advances and Innovations in Statistics and Data Science, pp. 225--234. <doi:10.1007/978-3-031-08329-7_10>. l) Alenazi A. (2023). "A review of compositional data analysis and recent advances". Communications in Statistics--Theory and Methods, 52(16): 5535--5567. <doi:10.1080/03610926.2021.2014890>. m) Tsagris M., Alenazi A. and Stewart C. (2023). "Flexible non--parametric regression models for compositional response data with zeros". Statistics and Computing, 33(106). <doi:10.1007/s11222-023-10277-5>. n) Tsagris. M. (2025). "Constrained least squares simplicial--simplicial regression". Statistics and Computing, 35(27). <doi:10.1007/s11222-024-10560-z>. o) Sevinc V. and Tsagris. M. (2026). "Energy Based Equality of Distributions Testing for Compositional Data". Communications in Statistics--Simulation and Computation. <doi:10.1080/03610918.2026.2636167>. p) Tsagris M. and Alzeley O. (2025). "Scalable approximation of the transformation--free linear simplicial--simplicial regression via constrained iterative reweighted least squares". <doi:10.48550/arXiv.2511.13296>.

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the R console with sgRNA_Design() or through crispRdesignR's user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

This package provides a large number of measurements generate count data. This is a statistical data type that only assumes non-negative integer values and is generated by counting. Typically, counting data can be found in biomedical applications, such as the analysis of DNA double-strand breaks. The number of DNA double-strand breaks can be counted in individual cells using various bioanalytical methods. For diagnostic applications, it is relevant to record the distribution of the number data in order to determine their biomedical significance (Roediger, S. et al., 2018. Journal of Laboratory and Precision Medicine. <doi:10.21037/jlpm.2018.04.10>). The software offers functions for a comprehensive automated evaluation of distribution models of count data. In addition to programmatic interaction, a graphical user interface (web server) is included, which enables fast and interactive data-scientific analyses. The user is supported in selecting the most suitable counting distribution for his own data set.

An implementation of the clugen algorithm for generating multidimensional clusters with arbitrary distributions. Each cluster is supported by a line segment, the position, orientation and length of which guide where the respective points are placed. This package is described in Fachada & de Andrade (2023) <doi:10.1016/j.knosys.2023.110836>.

This package implements the Capability-Ecological Developmental Model (CEDM) for longitudinal and multilevel data. The package supports estimation and interpretation of models examining how socioeconomic status (SES), health indicators, and contextual factors jointly relate to academic outcomes. Functionality includes: (1) classification of ecological capability regimes (amplifying, neutral, compensatory); (2) estimation of moderated multilevel models with higher-order interaction terms; (3) causal mediation analysis using doubly robust estimation; (4) random-effects within-between (REWB) decomposition; (5) nonlinear moderation using restricted cubic splines; (6) clustering of longitudinal health trajectories; and (7) sensitivity analysis using the impact threshold for a confounding variable (ITCV) and robustness-to-replacement (RIR) measures. The package is designed for use with general longitudinal multilevel datasets.

Interface to the ComexStat API <https://comexstat.mdic.gov.br/> from the Brazilian Ministry of Development, Industry, Trade and Services (MDIC). Provides access to detailed export and import data, including general trade statistics (1997-present), city-level data, historical data (1989-1996), and auxiliary tables with product codes (NCM - Nomenclatura Comum do Mercosul, NBM - Nomenclatura Brasileira de Mercadorias, HS - Harmonized System), countries, economic classifications (CGCE - Classificacao por Grandes Categorias Economicas, SITC - Standard International Trade Classification, ISIC - International Standard Industrial Classification), and other categories. Uses only httr2 for HTTP requests and cli for console messages.

This package provides iterators for combinations, permutations, subsets, and Cartesian product, which allow one to go through all elements without creating a huge set of all possible values.

This package provides a simple way to write ".Rprofile" code in an R Markdown file and have it knit to the correct location for your operating system.

Posterior inference under the convex mixture regression (CoMiRe) models introduced by Canale, Durante, and Dunson (2018) <doi:10.1111/biom.12917>.

This package provides a toolkit for making use of credentials mediated by Posit Connect'. It handles the details of communicating with the Connect API correctly, OAuth token caching, and refresh behaviour.

This package implements the Conditional Ordinal Stereotype Model for Incident-Level Comparison (COSMIC), a method for analyzing ordinal outcomes observed across multiple actors within shared events. The model uses a conditional likelihood to remove event-level confounding and estimate actor-specific propensities relative to their peers. Efficient computation is achieved via a dynamic programming algorithm for the Poisson-multinomial normalization term, enabling scalable estimation with Markov chain Monte Carlo. The package provides tools for data preparation, model fitting using Stan, and extraction of posterior summaries for comparative inference. Estimation of police officer propensity to escalate force is the primary motivation for the model. For more details see Ridgeway (2026) "A Conditional Ordinal Stereotype Model to Estimate Police Officersâ Propensity to Escalate Force" <doi:10.1080/01621459.2025.2597050>.

Includes commands for bootstrapping and permutation tests, a command for created grouped bar plots, and a demo of the quantile-normal plot for data drawn from different distributions.

Implementation of the empirical method to derive log2 counts per million (CPM) cutoff to filter out lowly expressed genes using ERCC spike-ins as described in Goll and Bosinger et.al (2022)<doi:10.1101/2022.06.23.497396>. This package utilizes the synthetic mRNA control pairs developed by the External RNA Controls Consortium (ERCC) (ERCC 1 / ERCC 2) that are spiked into sample pairs at known ratios at various absolute abundances. The relationship between the observed and expected fold changes is then used to empirically determine an optimal log2 CPM cutoff for filtering out lowly expressed genes.

Model soil gas fluxes with the Flux-Gradient Method. It includes functions for data handling, a forward and an inverse model for flux modeling and methods for calibration and uncertainty estimation. For more details see Gartiser et al. (2025a) <doi:10.21105/joss.08094> and Gartiser et al. (2025b) <doi:10.1111/ejss.70126>.

This package provides a simple, fast algorithm to find the neighbors and similarities of users in user-based filtering systems, to break free from the complex computation of existing similarity formulas and the ability to solve big data.

Conditional mixture model fitted via EM (Expectation Maximization) algorithm for model-based clustering, including parsimonious procedure, optimal conditional order exploration, and visualization.

Git hook scripts are useful for identifying simple issues before submission to code review. captain (hook) is an R package to manage and run git pre-commit hooks.