Generates an RMarkdown data report with two components: a summary of an input dataset and a diff of the dataset relative to an old version.

This package performs reference based multiple imputation of recurrent event data based on a negative binomial regression model, as described by Keene et al (2014) <doi:10.1002/pst.1624>.

Fast computation of the distance covariance dcov and distance correlation dcor'. The computation cost is only O(n log(n)) for the distance correlation (see Chaudhuri, Hu (2019) <arXiv:1810.11332> <doi:10.1016/j.csda.2019.01.016>). The functions are written entirely in C++ to speed up the computation.

This package provides landscape genomic functions to analyse SNP (single nuclear polymorphism) data, such as least cost path analysis and isolation by distance. Therefore each sample needs to have coordinate data attached (lat/lon) to be able to run most of the functions. dartR.spatial is a package that belongs to the dartRverse suit of packages and depends on dartR.base and dartR.data'.

This package provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The dtpcrm package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

Differential Analysis of short RNA transcripts that can be modeled by either Poisson or Negative binomial distribution. The statistical methodology implemented in this package is based on the random selection of references genes (Desaulle et al. (2021) <arXiv:2103.09872>).

In practice, we will encounter problems where the longitudinal performance of processes needs to be monitored over time. Dynamic screening systems (DySS) are methods that aim to identify and give signals to processes with poor performance as early as possible. This package is designed to implement dynamic screening systems and the related methods. References: Qiu, P. and Xiang, D. (2014) <doi:10.1080/00401706.2013.822423>; Qiu, P. and Xiang, D. (2015) <doi:10.1002/sim.6477>; Li, J. and Qiu, P. (2016) <doi:10.1080/0740817X.2016.1146423>; Li, J. and Qiu, P. (2017) <doi:10.1002/qre.2160>; You, L. and Qiu, P. (2019) <doi:10.1080/00949655.2018.1552273>; Qiu, P., Xia, Z., and You, L. (2020) <doi:10.1080/00401706.2019.1604434>; You, L., Qiu, A., Huang, B., and Qiu, P. (2020) <doi:10.1002/bimj.201900127>; You, L. and Qiu, P. (2021) <doi:10.1080/00224065.2020.1767006>.

Specify, solve, and estimate dynamic stochastic general equilibrium (DSGE) models by maximum likelihood and Bayesian methods. Supports both linear models via an equation-based formula interface and nonlinear models via string-based equations with first-order perturbation (linearization around deterministic steady state). Solution uses the method of undetermined coefficients (Klein, 2000 <doi:10.1016/S0165-1889(99)00045-7>). Likelihood evaluated via the Kalman filter. Bayesian estimation uses adaptive Random-Walk Metropolis-Hastings with prior specification. Additional tools include Kalman smoothing, historical shock decomposition, local identification diagnostics, parameter sensitivity analysis, second-order perturbation, occasionally binding constraints, impulse-response functions, forecasting, and robust standard errors.

Calculate and analyze ecological connectivity across the watercourse of river networks using the Dendritic Connectivity Index.

This package performs detection of Differential Item Functioning using the method DIFboost as proposed by Schauberger and Tutz (2016) <doi:10.1111/bmsp.12060>.

The Discrete Transmuted Generalized Inverse Weibull (DTGIW) distribution is a new distribution for count data analysis. The DTGIW is discrete distribution based on Atchanut and Sirinapa (2021). <DOI: 10.14456/sjst-psu.2021.149>.

Here, a function has been developed to generate parameters of the input designs, as well as incidence matrices. This is a general function that can be used to investigate the characterization properties of any block design.

Given the non-negative data and its distribution, the package estimates the rank parameter for Non-negative Matrix Factorization. The method is based on hypothesis testing, using a deconvolved bootstrap distribution to assess the significance level accurately despite the large amount of optimization error. The distribution of the non-negative data can be either Normal distributed or Poisson distributed.

This package implements the distribution-free goodness-of-fit regression test for the mean structure of parametric models introduced in Khmaladze (2021) <doi:10.1007/s10463-021-00786-3>. The test is implemented for general functions with minimal distributional assumptions as well as common models (e.g., lm, glm) with the usual assumptions.

This package provides a grammar of data manipulation with data.table', providing a consistent a series of utility functions that help you solve the most common data manipulation challenges.

Statistical hypothesis testing of pattern heterogeneity via differences in underlying distributions across multiple contingency tables. Five tests are included: the comparative chi-squared test (Song et al. 2014) <doi:10.1093/nar/gku086> (Zhang et al. 2015) <doi:10.1093/nar/gkv358>, the Sharma-Song test (Sharma et al. 2021) <doi:10.1093/bioinformatics/btab240>, the heterogeneity test, the marginal-change test (Sharma et al. 2020) <doi:10.1145/3388440.3412485>, and the strength test (Sharma et al. 2020) <doi:10.1145/3388440.3412485>. Under the null hypothesis that row and column variables are statistically independent and joint distributions are equal, their test statistics all follow an asymptotically chi-squared distribution. A comprehensive type analysis categorizes the relation among the contingency tables into type null, 0, 1, and 2 (Sharma et al. 2020) <doi:10.1145/3388440.3412485>. They can identify heterogeneous patterns that differ in either the first order (marginal) or the second order (differential departure from independence). Second-order differences reveal more fundamental changes than first-order differences across heterogeneous patterns.

This package implements the Oaxaca-Blinder decomposition method and generalizations of it that decompose differences in distributional statistics beyond the mean. The function ob_decompose() decomposes differences in the mean outcome between two groups into one part explained by different covariates (composition effect) and into another part due to differences in the way covariates are linked to the outcome variable (structure effect). The function further divides the two effects into the contribution of each covariate and allows for weighted doubly robust decompositions. For distributional statistics beyond the mean, the function performs the recentered influence function (RIF) decomposition proposed by Firpo, Fortin, and Lemieux (2018). The function dfl_decompose() divides differences in distributional statistics into an composition effect and a structure effect using inverse probability weighting as introduced by DiNardo, Fortin, and Lemieux (1996). The function also allows to sequentially decompose the composition effect into the contribution of single covariates. References: Firpo, Sergio, Nicole M. Fortin, and Thomas Lemieux. (2018) <doi:10.3390/econometrics6020028>. "Decomposing Wage Distributions Using Recentered Influence Function Regressions." Fortin, Nicole M., Thomas Lemieux, and Sergio Firpo. (2011) <doi:10.3386/w16045>. "Decomposition Methods in Economics." DiNardo, John, Nicole M. Fortin, and Thomas Lemieux. (1996) <doi:10.2307/2171954>. "Labor Market Institutions and the Distribution of Wages, 1973-1992: A Semiparametric Approach." Oaxaca, Ronald. (1973) <doi:10.2307/2525981>. "Male-Female Wage Differentials in Urban Labor Markets." Blinder, Alan S. (1973) <doi:10.2307/144855>. "Wage Discrimination: Reduced Form and Structural Estimates.".

S4 classes around infrastructure provided by the coda and dclone packages to make package development easy as a breeze with data cloning for hierarchical models.

Estimates Two-way Fixed Effects difference-in-differences/event-study models using the approach proposed by Gardner (2021) <doi:10.48550/arXiv.2207.05943>. To avoid the problems caused by OLS estimation of the Two-way Fixed Effects model, this function first estimates the fixed effects and covariates using untreated observations and then in a second stage, estimates the treatment effects.

Allows clinicians and researchers to compute daily dose (and subsequently days supply) for prescription refills using the following methods: Fixed window, fixed tablet, defined daily dose (DDD), and Random Effects Warfarin Days Supply (REWarDS). Daily dose is the computed dose that the patient takes every day. For medications with fixed dosing (e.g. direct oral anticoagulants) this is known and does not need to be estimated. For medications with varying dose such as warfarin, however, the daily dose should be assumed or estimated to allow measurement of drug exposure. Daysâ supply is the number of days that patientsâ supply of medication will last after each prescription fill. Estimating daysâ supply is necessary to calculate drug exposure. The package computes daysâ supply and daily dose at both the prescription and patient levels. Results at the prescription level are denoted with â -Rx-â and those at patient level are denoted with â -Pt-â .

This package provides a full definition for Weibull tails and Full-Tails Gamma and tools for fitting these distributions to empirical tails. This package build upon the paper by del Castillo, Joan & Daoudi, Jalila & Serra, Isabel. (2012) <doi:10.1017/asb.2017.9>.

Similarity of dissolution profiles is assessed using the similarity factor f2 according to the EMA guideline (European Medicines Agency 2010) "On the investigation of bioequivalence". Dissolution profiles are regarded as similar if the f2 value is between 50 and 100. For the applicability of the similarity factor f2, the variability between profiles needs to be within certain limits. Often, this constraint is violated. One possibility in this situation is to resample the measured profiles in order to obtain a bootstrap estimate of f2 (Shah et al. (1998) <doi:10.1023/A:1011976615750>). Other alternatives are the model-independent non-parametric multivariate confidence region (MCR) procedure (Tsong et al. (1996) <doi:10.1177/009286159603000427>) or the T2-test for equivalence procedure (Hoffelder (2016) <https://www.ecv.de/suse_item.php?suseId=Z|pi|8430>). Functions for estimation of f1, f2, bootstrap f2, MCR / T2-test for equivalence procedure are implemented.

Models for analyzing site occupancy and count data models with detection error, including single-visit based models (Lele et al. 2012 <doi:10.1093/jpe/rtr042>, Moreno et al. 2010 <doi:10.1890/09-1073.1>, Solymos et al. 2012 <doi:10.1002/env.1149>, Denes et al. 2016 <doi:10.1111/1365-2664.12818>), conditional distance sampling and time-removal models (QPAD) (Solymos et al. 2013 <doi:10.1111/2041-210X.12106>, Solymos et al. 2018 <doi:10.1650/CONDOR-18-32.1>), and single bin QPAD (SQPAD) models (Lele & Solymos 2025 <doi:10.1093/ornithapp/duaf078>). Package development was supported by the Alberta Biodiversity Monitoring Institute and the Boreal Avian Modelling Project.

CRAN packages DoE.base and Rmosek and non-'CRAN package gurobi are enhanced with functionality for the creation of optimized arrays for experimentation, where optimization is in terms of generalized minimum aberration. It is also possible to optimally extend existing arrays to larger run size. The package writes MPS (Mathematical Programming System) files for use with any mixed integer optimization software that can process such files. If at least one of the commercial products Gurobi or Mosek (free academic licenses available for both) is available, the package also creates arrays by optimization. For installing Gurobi and its R package gurobi', follow instructions at <https://support.gurobi.com/hc/en-us/articles/14462206790033-How-do-I-install-Gurobi-for-R>. For installing Mosek and its R package Rmosek', follow instructions at <https://www.mosek.com/downloads/> and <https://docs.mosek.com/8.1/rmosek/install-interface.html>, or use the functionality in the stump CRAN R package Rmosek'.