This package contains more modern tools for causal inference using regression standardization. Four general classes of models are implemented; generalized linear models, conditional generalized estimating equation models, Cox proportional hazards models, and shared frailty gamma-Weibull models. Methodological details are described in Sjölander, A. (2016) <doi:10.1007/s10654-016-0157-3>. Also includes functionality for doubly robust estimation for generalized linear models in some special cases, and the ability to implement custom models.

Computes the Exposure-At-Default based on the standardized approach of CRR2 (SA-CCR). The simplified version of SA-CCR has been included, as well as the OEM methodology. Multiple trade types of all the five major asset classes are being supported including the Other Exposure and, given the inheritance- based structure of the application, the addition of further trade types is straightforward. The application returns a list of trees per Counterparty and CSA after automatically separating the trades based on the Counterparty, the CSAs, the hedging sets, the netting sets and the risk factors. The basis and volatility transactions are also identified and treated in specific hedging sets whereby the corresponding penalty factors are applied. All the examples appearing on the regulatory papers (both for the margined and the unmargined workflow) have been implemented including the latest CRR2 developments.

Measures memory and CPU usage of R code by regularly taking snapshots of calls to the system command ps'. The package provides an entry point (albeit coarse) to profile usage of system resources by R code run in parallel.

SigClust is a statistical method for testing the significance of clustering results. SigClust can be applied to assess the statistical significance of splitting a data set into two clusters. For more than two clusters, SigClust can be used iteratively.

SMART trial design, as described by He, J., McClish, D., Sabo, R. (2021) <doi:10.1080/19466315.2021.1883472>, includes multiple stages of randomization, where participants are randomized to an initial treatment in the first stage and then subsequently re-randomized between treatments in the following stage.

An automatic cell type detection and assignment algorithm for single cell RNA-Seq and Cytof/FACS data. SCINA is capable of assigning cell type identities to a pool of cells profiled by scRNA-Seq or Cytof/FACS data with prior knowledge of markers, such as genes and protein symbols that are highly or lowly expressed in each category. See Zhang Z, et al (2019) <doi:10.3390/genes10070531> for more details.

Selection of spatially balanced samples. In particular, the implemented sampling designs allow to select probability samples well spread over the population of interest, in any dimension and using any distance function (e.g. Euclidean distance, Manhattan distance). For more details, Pantalone F, Benedetti R, and Piersimoni F (2022) <doi:10.18637/jss.v103.c02>, Benedetti R and Piersimoni F (2017) <doi:10.1002/bimj.201600194>, and Benedetti R and Piersimoni F (2017) <arXiv:1710.09116>. The implementation has been done in C++ through the use of Rcpp and RcppArmadillo'.

Visualization and analysis of Vectra Immunoflourescent data. Options for calculating both the univariate and bivariate Ripley's K are included. Calculations are performed using a permutation-based approach presented by Wilson et al. <doi:10.1101/2021.04.27.21256104>.

It is a hybrid spatial model that combines the variable selection capabilities of stepwise regression methods with the predictive power of the Geographically Weighted Regression(GWR) model.The developed hybrid model follows a two-step approach where the stepwise variable selection method is applied first to identify the subset of predictors that have the most significant impact on the response variable, and then a GWR model is fitted using those selected variables for spatial prediction at test or unknown locations. For method details,see Leung, Y., Mei, C. L. and Zhang, W. X. (2000).<DOI:10.1068/a3162>.This hybrid spatial model aims to improve the accuracy and interpretability of GWR predictions by selecting a subset of relevant variables through a stepwise selection process.This approach is particularly useful for modeling spatially varying relationships and improving the accuracy of spatial predictions.

This package provides functions to implement group sequential procedures that allow for early stopping to declare efficacy using a surrogate marker and the possibility of futility stopping. More details are available in: Parast, L. and Bartroff, J (2024) <doi:10.1093/biomtc/ujae108>. A tutorial for this package can be found at <https://www.laylaparast.com/surrogateseq>. A Shiny App implementing the methods can be found at <https://parastlab.shinyapps.io/SurrogateSeqApp/>.

Create and format tables and APA statistics for scientific publication. This includes making a Table 1 to summarize demographics across groups, correlation tables with significance indicated by stars, and extracting formatted statistical summarizes from simple tests for in-text notation. The package also includes functions for Winsorizing data based on a Z-statistic cutoff.

Select sampling methods for probability samples using large data sets. This includes spatially balanced sampling in multi-dimensional spaces with any prescribed inclusion probabilities. All implementations are written in C with efficient data structures such as k-d trees that easily scale to several million rows on a modern desktop computer.

Format a number (or a list of numbers) to a string (or a list of strings) with SI prefix. Use SI prefixes as constants like (4 * milli)^2.

This package provides a set of functions to create SQL tables of gene and SNP information and compose them into a SNP Set, for example to export to a PLINK set.

Transforms or simulates data with a target empirical covariance matrix supplied by the user. The method to obtain the data with the target empirical covariance matrix is described in Section 5.1 of Christidis, Van Aelst and Zamar (2019) <arXiv:1812.05678>.

Generates random values from a univariate and multivariate continuous distribution by using kernel density estimation based on a sample. Duong (2017) <doi:10.18637/jss.v021.i07>, Christian P. Robert and George Casella (2010 ISBN:978-1-4419-1575-7) <doi:10.1007/978-1-4419-1576-4>.

This package implements a method to combine multiple levels of multiple sequence alignment to uncover the structure of complex DNA rearrangements.

Several functions are provided for small area estimation at the area level using the hierarchical bayesian (HB) method with panel data under beta distribution for variable interest. This package also provides a dataset produced by data generation. The rjags package is employed to obtain parameter estimates. Model-based estimators involve the HB estimators, which include the mean and the variation of the mean. For the reference, see Rao and Molina (2015, ISBN: 978-1-118-73578-7).

This package provides drop-in replacements for functions from the stringr package, with the same user interface. These functions have no external dependencies and can be copied directly into your package code using the staticimports package.

Visualizes sulcal morphometry data derived from BrainVisa <https://brainvisa.info/> including width, depth, surface area, and length. The package enables mapping of statistical group results or subject-level values onto cortical surface maps, with options to focus on all sulci or only selected regions of interest. Users can display all four measures simultaneously or restrict plots to chosen measures, creating composite, publication-quality brain visualizations in R to support the analysis and interpretation of sulcal morphology.

Store persistent and synchronized data from shiny inputs within the browser. Refresh shiny applications and preserve user-inputs over multiple sessions. A database-like storage format is implemented using Dexie.js <https://dexie.org>, a minimal wrapper for IndexedDB'. Transfer browser link parameters to shiny input or output values. Store app visitor views, likes and followers.

Analyse light spectra for visual and non-visual (often called melanopic) needs, wrapped up in a Shiny App. Spectran allows for the import of spectra in various CSV forms but also provides a wide range of example spectra and even the creation of own spectral power distributions. The goal of the app is to provide easy access and a visual overview of the spectral calculations underlying common parameters used in the field. It is thus ideal for educational purposes or the creation of presentation ready graphs in lighting research and application. Spectran uses equations and action spectra described in CIE S026 (2018) <doi:10.25039/S026.2018>, DIN/TS 5031-100 (2021) <doi:10.31030/3287213>, and ISO/CIE 23539 (2023) <doi:10.25039/IS0.CIE.23539.2023>.

This package provides extensions for package sitree for allometric variables, growth, mortality, recruitment, management, tree removal and external modifiers functions.

This package provides a series of checks to identify common issues in Study Data Tabulation Model (SDTM) datasets. These checks are intended to be generalizable, actionable, and meaningful for analysis.