This package implements the simpler and faster heat index, which matches the values of the original 1979 heat index and its 2022 extension for air temperatures above 300 K (27 C, 80 F) and with only minor differences at lower temperatures. Also implements an algorithm for calculating the thermodynamic (and psychrometric) wet-bulb (and ice-bulb) temperature.

Offers a convenient way to compute parameters in the framework of the theory of vocational choice introduced by J.L. Holland, (1997). A comprehensive summary to this theory of vocational choice is given in Holland, J.L. (1997). Making vocational choices. A theory of vocational personalities and work environments. Lutz, FL: Psychological Assessment.

This package provides utility functions that are simply, frequently used, but may require higher performance that what can be obtained from base R. Incidentally provides support for reverse geocoding', such as matching a point with its nearest neighbour in another array. Used as a complement to package hutils by sacrificing compilation or installation time for higher running speeds. The name is a portmanteau of the author and Rcpp'.

The Harmonised Index of Consumer Prices (HICP) is the key economic figure to measure inflation in the euro area. The methodology underlying the HICP is documented in the HICP Methodological Manual (<https://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/w/ks-gq-24-003>). Based on the manual, this package provides functions to access and work with HICP data from Eurostat's public database (<https://ec.europa.eu/eurostat/data/database>).

Calculate clinical scores for hidradenitis suppurativa (HS), a dermatologic disease. The scores are typically used for evaluation of efficacy in clinical trials. The scores are not commonly used in clinical practice. The specific scores implemented are Hidradenitis Suppurativa Clinical Response (HiSCR) (Kimball, et al. (2015) <doi:10.1111/jdv.13216>), Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R) (Goldfarb, et al. (2020) <doi:10.1111/bjd.19565>), hidradenitis suppurativa Physician Global Assessment (HS PGA) (Marzano, et al. (2020) <doi:10.1111/jdv.16328>), and the International Hidradenitis Suppurativa Severity Score System (IHS4) (Zouboulis, et al. (2017) <doi:10.1111/bjd.15748>).

This package provides uniform testing procedures for existence and heterogeneity of threshold effects in high-dimensional nonparametric panel regression models. The package accompanies the paper Chen, Keilbar, Su and Wang (2023) "Inference on many jumps in nonparametric panel regression models". arXiv preprint <doi:10.48550/arXiv.2312.01162>.

This package provides a consistent API for hypothesis testing built on principles from Structure and Interpretation of Computer Programs': data abstraction, closure (combining tests yields tests), and higher-order functions (transforming tests). Implements z-tests, Wald tests, likelihood ratio tests, Fisher's method for combining p-values, and multiple testing corrections. Designed for use by other packages that want to wrap their hypothesis tests in a consistent interface.

Functions, data sets, analyses and examples from the second edition of the book A Handbook of Statistical Analyses Using R (Brian S. Everitt and Torsten Hothorn, Chapman & Hall/CRC, 2008). The first chapter of the book, which is entitled An Introduction to R'', is completely included in this package, for all other chapters, a vignette containing all data analyses is available. In addition, the package contains Sweave code for producing slides for selected chapters (see HSAUR2/inst/slides).

Implementation of the HespDiv framework for hierarchical spatial subdivision of geographical occurrence data. The main function hespdiv() performs iterative spatially constrained subdivision of a study area to identify topologically contiguous clusters in geographic space using user-defined or preset subdivision methods. Additional functions provide tools for analysing subdivision results, visualizing hierarchical spatial structures, and evaluating robustness through sensitivity analyses and statistical testing. Some examples use the optional HDData data package, which is available from GitHub at Liudas-Dau/hespdiv_data. The methodology is described in Daumantas and Spiridonov (2024) <doi:10.1111/pala.12702>.

This package provides a protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis. It provides a pipeline for analyzing data from HDXExaminer (Sierra Analytics, Trajan Scientific), automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework. Additionally, it simplifies data export, generates PyMol scripts, and ensures calculations meet publication standards. HDXBoxeR assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides, generating plots, and facilitating comparison between protein states. For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325> and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>. HDXBoxeR citation: Janowska et al. (2024) <doi:10.1093/bioinformatics/btae479>.

Various functions and algorithms are provided here for solving optimal matching tasks in the context of preclinical cancer studies. Further, various helper and plotting functions are provided for unsupervised and supervised machine learning as well as longitudinal mixed-effects modeling of tumor growth response patterns.

Fits hidden Markov models with discrete non-parametric observation distributions to data sets. The observations may be univariate or bivariate. Simulates data from such models. Finds most probable underlying hidden states, the most probable sequences of such states, and the log likelihood of a collection of observations given the parameters of the model. Auxiliary predictors are accommodated in the univariate setting.

This package provides a suite of functions to ping URLs and to time HTTP requests'. Designed to work with httr'.

Several functions that allow by different methods to infer a piecewise polynomial regression model under regularity constraints, namely continuity or differentiability of the link function. The implemented functions are either specific to data with two regimes, or generic for any number of regimes, which can be given by the user or learned by the algorithm. A paper describing all these methods will be submitted soon. The reference will be added to this file as soon as available.

The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as GoMiner (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. Microarray studies are usually analyzed with BP, whereas proteomics researchers often prefer CC. To capture the benefit of both of those ontologies, I now present an enhancement of the existing two-dimensional version of High-Throughput GoMiner ('HTGM2D'), which is called HTGM4D'. The original HTGM2D is augmented by adding two instances of the original GoMiner genes versus categories heatmaps, aligned with the categories axes of the HTGM2D heatmap.

Tests for a treatment effect using surrogate marker information accounting for heterogeneity in the utility of the surrogate. Details are described in Parast et al (2022) <arXiv:2209.08315>.

The theoretical covariance between pairs of markers is calculated from either paternal haplotypes and maternal linkage disequilibrium (LD) or vise versa. A genetic map is required. Grouping of markers is based on the correlation matrix and a representative marker is suggested for each group. Employing the correlation matrix, optimal sample size can be derived for association studies based on a SNP-BLUP approach. The implementation relies on paternal half-sib families and biallelic markers. If maternal half-sib families are used, the roles of sire/dam are swapped. Multiple families can be considered. Wittenburg, Bonk, Doschoris, Reyer (2020) "Design of Experiments for Fine-Mapping Quantitative Trait Loci in Livestock Populations" <doi:10.1186/s12863-020-00871-1>. Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004) "Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium" <doi:10.1086/381000>.

This package provides functions to assess and test for heterogeneity in the utility of a surrogate marker with respect to a baseline covariate using censored (survival data), and to test for heterogeneity across multiple time points. More details are available in Parast et al (2024) <doi:10.1002/sim.10122>.

This package provides a case conversion between common cases like CamelCase and snake_case. Using the rust crate heck <https://github.com/withoutboats/heck> as the backend for a highly performant case conversion for R'.

Identifies regime changes in streamflow runoff not explained by variations in precipitation. The package builds a flexible set of Hidden Markov Models of annual, seasonal or monthly streamflow runoff with precipitation as a predictor. Suites of models can be built for a single site, ranging from one to three states and each with differing combinations of error models and auto-correlation terms. The most parsimonious model is easily identified by AIC, and useful for understanding catchment drought non-recovery: Peterson TJ, Saft M, Peel MC & John A (2021) <doi:10.1126/science.abd5085>.

This package implements the method developed by Cao and Kosorok (2011) for the significance analysis of thousands of features in high-dimensional biological studies. It is an asymptotically valid data-driven procedure to find critical values for rejection regions controlling the k-familywise error rate, false discovery rate, and the tail probability of false discovery proportion.

This package provides functions for determining and evaluating high-risk zones and simulating and thinning point process data, as described in Determining high risk zones using point process methodology - Realization by building an R package Seibold (2012) <http://highriskzone.r-forge.r-project.org/Bachelorarbeit.pdf> and Determining high-risk zones for unexploded World War II bombs by using point process methodology', Mahling et al. (2013) <doi:10.1111/j.1467-9876.2012.01055.x>.

Allows to estimate and test high-dimensional mediation effects based on advanced mediator screening and penalized regression techniques. Methods used in the package refer to Zhang H, Zheng Y, Hou L, Liu L, HIMA: An R Package for High-Dimensional Mediation Analysis. Journal of Data Science. (2025). <doi:10.6339/25-JDS1192>.

Analysis of plant pathogen pathotype survey data. Functions provided calculate distribution of susceptibilities, distribution of complexities with statistics, pathotype frequency distribution, as well as diversity indices for pathotypes. This package is meant to be a direct replacement for Herrmann, Löwer and Schachtel's (1999) <doi:10.1046/j.1365-3059.1999.00325.x> Habgood-Gilmour Spreadsheet, HaGiS', previously used for pathotype analysis.