This package provides statistical tools for Bayesian estimation of mixture distributions, mainly a mixture of Gamma, Normal, and t-distributions. The package is implemented based on the Bayesian literature for the finite mixture of distributions, including Mohammadi and et al. (2013) <doi:10.1007/s00180-012-0323-3> and Mohammadi and Salehi-Rad (2012) <doi:10.1080/03610918.2011.588358>.

Fit semiparametric bivariate correlated frailty models.

Search, query, and download tabular and geospatial data from the British Columbia Data Catalogue (<https://catalogue.data.gov.bc.ca/>). Search catalogue data records based on keywords, data licence, sector, data format, and B.C. government organization. View metadata directly in R, download many data formats, and query geospatial data available via the B.C. government Web Feature Service ('WFS') using dplyr syntax.

Fit two-regime threshold autoregressive (TAR) models by Markov chain Monte Carlo methods.

Broadly useful convenient and efficient R functions that bring users concise and elegant R data analyses. This package includes easy-to-use functions for (1) basic R programming (e.g., set working directory to the path of currently opened file; import/export data from/to files in any format; print tables to Microsoft Word); (2) multivariate computation (e.g., compute scale sums/means/... with reverse scoring); (3) reliability analyses and factor analyses; (4) descriptive statistics and correlation analyses; (5) t-test, multi-factor analysis of variance (ANOVA), simple-effect analysis, and post-hoc multiple comparison; (6) tidy report of statistical models (to R Console and Microsoft Word); (7) mediation and moderation analyses (PROCESS); and (8) additional toolbox for statistics and graphics.

This package provides a statistical tool to inference the multi-level partial correlations based on multi-subject time series data, especially for brain functional connectivity. It combines both individual and population level inference by using the methods of Qiu and Zhou. (2021)<DOI: 10.1080/01621459.2021.1917417> and Genovese and Wasserman. (2006)<DOI: 10.1198/016214506000000339>. It realizes two reliable estimation methods of partial correlation coefficients, using scaled lasso and lasso. It can be used to estimate individual- or population-level partial correlations, identify nonzero ones, and find out unequal partial correlation coefficients between two populations.

Computation of key characteristics and plots for blinded sample size recalculation. Continuous as well as binary endpoints are supported in superiority and non-inferiority trials. See Baumann, Pilz, Kieser (2022) <doi:10.32614/RJ-2022-001> for a detailed description. The implemented methods include the approaches by Lu, K. (2019) <doi:10.1002/pst.1737>, Kieser, M. and Friede, T. (2000) <doi:10.1002/(SICI)1097-0258(20000415)19:7%3C901::AID-SIM405%3E3.0.CO;2-L>, Friede, T. and Kieser, M. (2004) <doi:10.1002/pst.140>, Friede, T., Mitchell, C., Mueller-Veltern, G. (2007) <doi:10.1002/bimj.200610373>, and Friede, T. and Kieser, M. (2011) <doi:10.3414/ME09-01-0063>.

Smoothed lexis diagrams with Bayesian method specifically tailored to cancer incidence data. Providing to calculating slope and constructing credible interval. LC Chien et al. (2015) <doi:10.1080/01621459.2015.1042106>. LH Chien et al. (2017) <doi:10.1002/cam4.1102>.

Function bipmod() that partitions a bipartite network into non-overlapping biclusters by maximizing bipartite modularity defined in Barber (2007) <doi:10.1103/PhysRevE.76.066102> using the bipartite version of the algorithm described in Treviño (2015) <doi:10.1088/1742-5468/2015/02/P02003>.

Utility functions, datasets and extended examples for survival analysis. This extends a range of other packages, some simple wrappers for time-to-event analyses, datasets, and extensive examples in HTML with R scripts. The package also supports the course Biostatistics III entitled "Survival analysis for epidemiologists in R".

This package provides a family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <doi:10.48550/arXiv.2211.01938> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.

The Bayesian MCMC estimation of parameters for Thomas-type cluster point process with various inhomogeneities. It allows for inhomogeneity in (i) distribution of parent points, (ii) mean number of points in a cluster, (iii) cluster spread. The package also allows for the Bayesian MCMC algorithm for the homogeneous generalized Thomas process. The cluster size is allowed to have a variance that is greater or less than the expected value (cluster sizes are over or under dispersed). Details are described in DvoŠák, RemeÅ¡, Beránek & MrkviÄ ka (2022) <arXiv: 10.48550/arXiv.2205.07946>.

Spike and slab regression with a variety of residual error distributions corresponding to Gaussian, Student T, probit, logit, SVM, and a few others. Spike and slab regression is Bayesian regression with prior distributions containing a point mass at zero. The posterior updates the amount of mass on this point, leading to a posterior distribution that is actually sparse, in the sense that if you sample from it many coefficients are actually zeros. Sampling from this posterior distribution is an elegant way to handle Bayesian variable selection and model averaging. See <DOI:10.1504/IJMMNO.2014.059942> for an explanation of the Gaussian case.

Calculates the bidimensional regression between two 2D configurations following the approach by Tobler (1965).

This package provides a modular framework for standardized analysis of thermal imaging data in animal experimentation. The package integrates thermographic data import (FLIR, raw, CSV), automated region of interest (ROI) segmentation based on EBImage (Pau et al., 2010 <doi:10.1093/bioinformatics/btq046>), interactive ROI refinement, and high-throughput batch processing.

This package provides tools for fitting Bayesian single index models with flexible choices of priors for both the index and the link function. The package implements model estimation and posterior inference using efficient MCMC algorithms built on the nimble framework, allowing users to specify, extend, and simulate models in a unified and reproducible manner. The following methods are implemented in the package: Antoniadis et al. (2004) <https://www.jstor.org/stable/24307224>, Wang (2009) <doi:10.1016/j.csda.2008.12.010>, Choi et al. (2011) <doi:10.1080/10485251003768019>, Dhara et al. (2019) <doi:10.1214/19-BA1170>, McGee et al. (2023) <doi:10.1111/biom.13569>.

This package provides the estimation algorithm to perform the demand estimation described in Berry, Levinsohn and Pakes (1995) <DOI:10.2307/2171802> . The routine uses analytic gradients and offers a large number of implemented integration methods and optimization routines.

This package provides Bayesian methods for comparing groups on multiple binary outcomes. Includes basic tests using multivariate Bernoulli distributions, subgroup analysis via generalized linear models, and multilevel models for clustered data. For statistical underpinnings, see Kavelaars, Mulder, and Kaptein (2020) <doi:10.1177/0962280220922256>, Kavelaars, Mulder, and Kaptein (2024) <doi:10.1080/00273171.2024.2337340>, and Kavelaars, Mulder, and Kaptein (2023) <doi:10.1186/s12874-023-02034-z>. An interactive shiny app to perform sample size computations is available.

Latent and Stochastic Block Model estimation by a Variational EM algorithm. Various probability distribution are provided (Bernoulli, Poisson...), with or without covariates.

Real-time quantitative polymerase chain reaction (qPCR) data sets by Batsch et al. (2008) <doi:10.1186/1471-2105-9-95>. This package provides five data sets, one for each PCR target: (i) rat SLC6A14, (ii) human SLC22A13, (iii) pig EMT, (iv) chicken ETT, and (v) human GAPDH. Each data set comprises a five-point, four-fold dilution series. For each concentration there are three replicates. Each amplification curve is 45 cycles long. Original raw data file: <https://static-content.springer.com/esm/art%3A10.1186%2F1471-2105-9-95/MediaObjects/12859_2007_2080_MOESM5_ESM.xls>.

Fits, validates and compares a number of Bayesian models for spatial and space time point referenced and areal unit data. Model fitting is done using several packages: rstan', INLA', spBayes', spTimer', spTDyn', CARBayes and CARBayesST'. Model comparison is performed using the DIC and WAIC, and K-fold cross-validation where the user is free to select their own subset of data rows for validation. Sahu (2022) <doi:10.1201/9780429318443> describes the methods in detail.

Whole-genome regression methods on Bayesian framework fitted via EM or Gibbs sampling, single step (<doi:10.1534/g3.119.400728>), univariate and multivariate (<doi:10.1186/s12711-022-00730-w>, <doi:10.1093/genetics/iyae179>), with optional kernel term and sampling techniques (<doi:10.1186/s12859-017-1582-3>).

This package provides a two-step Bayesian approach for mode inference following Cross, Hoogerheide, Labonne and van Dijk (2024) <doi:10.1016/j.econlet.2024.111579>). First, a mixture distribution is fitted on the data using a sparse finite mixture (SFM) Markov chain Monte Carlo (MCMC) algorithm. The number of mixture components does not have to be known; the size of the mixture is estimated endogenously through the SFM approach. Second, the modes of the estimated mixture at each MCMC draw are retrieved using algorithms specifically tailored for mode detection. These estimates are then used to construct posterior probabilities for the number of modes, their locations and uncertainties, providing a powerful tool for mode inference.

This package provides functions for the evaluation of basket trial designs with binary endpoints. Operating characteristics of a basket trial design are assessed by simulating trial data according to scenarios, analyzing the data with Bayesian hierarchical models (BHMs), and assessing decision probabilities on stratum and trial-level based on Go / No-go decision making. The package is build for high flexibility regarding decision rules, number of interim analyses, number of strata, and recruitment. The BHMs proposed by Berry et al. (2013) <doi:10.1177/1740774513497539> and Neuenschwander et al. (2016) <doi:10.1002/pst.1730>, as well as a model that combines both approaches are implemented. Functions are provided to implement Bayesian decision rules as for example proposed by Fisch et al. (2015) <doi:10.1177/2168479014533970>. In addition, posterior point estimates (mean/median) and credible intervals for response rates and some model parameters can be calculated. For simulated trial data, bias and mean squared errors of posterior point estimates for response rates can be provided.