Defines S3 vector data types for vectors of functional data (grid-based, spline-based or functional principal components-based) with all arithmetic and summary methods, derivation, integration and smoothing, plotting, data import and export, and data wrangling, such as re-evaluating, subsetting, sub-assigning, zooming into sub-domains, or extracting functional features like minima/maxima and their locations. The implementation allows including such vectors in data frames for joint analysis of functional and scalar variables.

Doubly-robust, non-parametric estimators for the transported average treatment effect from Rudolph, Williams, Stuart, and Diaz (2023) <doi:10.48550/arXiv.2304.00117> and the intent-to-treatment average treatment effect from Rudolph and van der Laan (2017) <doi:10.1111/rssb.12213>. Estimators are fit using cross-fitting and nuisance parameters are estimated using the Super Learner algorithm.

Temporal SNA tools for continuous- and discrete-time longitudinal networks having vertex, edge, and attribute dynamics stored in the networkDynamic format. This work was supported by grant R01HD68395 from the National Institute of Health.

This package implements a task queue system for asynchronous parallel computing using PostgreSQL <https://www.postgresql.org/> as a backend. Designed for embarrassingly parallel problems where tasks do not communicate with each other. Dynamically distributes tasks to workers, handles uneven load balancing, and allows new workers to join at any time. Particularly useful for running large numbers of independent tasks on high-performance computing (HPC) clusters with SLURM <https://slurm.schedmd.com/> job schedulers.

The goal of trainR is to provide a simple interface to the National Rail Enquiries (NRE) systems. There are few data feeds available, the simplest of them is Darwin, which provides real-time arrival and departure predictions, platform numbers, delay estimates, schedule changes and cancellations. Other data feeds provide historical data, Historic Service Performance (HSP), and much more. trainR simplifies the data retrieval, so that the users can focus on their analyses. For more details visit <https://www.nationalrail.co.uk/46391.aspx>.

Trust region algorithm for nonlinear optimization. Efficient when the Hessian of the objective function is sparse (i.e., relatively few nonzero cross-partial derivatives). See Braun, M. (2014) <doi:10.18637/jss.v060.i04>.

It includes functions like tropical addition, tropical multiplication for vectors and matrices. In tropical algebra, the tropical sum of two numbers is their minimum and the tropical product of two numbers is their ordinary sum. For more information see also I. Simon (1988) Recognizable sets with multiplicities in the tropical semi ring: Volume 324 Lecture Notes I Computer Science, pages 107-120 <doi: 10.1007/BFb0017135>.

Two stage curvature identification with machine learning for causal inference in settings when instrumental variable regression is not suitable because of potentially invalid instrumental variables. Based on Guo and Buehlmann (2022) "Two Stage Curvature Identification with Machine Learning: Causal Inference with Possibly Invalid Instrumental Variables" <doi:10.48550/arXiv.2203.12808>. The vignette is available in Carl, Emmenegger, Bühlmann and Guo (2025) "TSCI: Two Stage Curvature Identification for Causal Inference with Invalid Instruments in R" <doi:10.18637/jss.v114.i07>.

Tree Ring Analysis of Disturbance Events in R (TRADER) package provides functions for disturbance reconstruction from tree-ring data, e.g. boundary line, absolute increase, growth averaging methods.

This package provides a plug-in for the tm text mining framework providing mail handling functionality.

An implementation of the time-series Susceptible-Infected-Recovered (TSIR) model using a number of different fitting options for infectious disease time series data. The manuscript based on this package can be found here <doi:10.1371/journal.pone.0185528>. The method implemented here is described by Finkenstadt and Grenfell (2000) <doi:10.1111/1467-9876.00187>.

Documentation for commonly-used objects included in the base distribution of R. Note that tldrDocs does not export any functions itself, its purpose is to write .Rd files during its installation for tldr() to find.

Enables users to build ToxPi prioritization models and provides functionality within the grid framework for plotting ToxPi graphs. toxpiR allows for more customization than the ToxPi GUI (<https://toxpi.github.io/>) and integration into existing workflows for greater ease-of-use, reproducibility, and transparency. toxpiR package behaves nearly identically to the GUI; the package documentation includes notes about all differences. The vignettes download example files from <https://github.com/ToxPi/ToxPi-example-files>.

Extends the test-based Bayes factor (TBF) methodology to multinomial regression models and discrete time-to-event models with competing risks. The TBF methodology has been well developed and implemented for the generalised linear model [Held et al. (2015) <doi:10.1214/14-STS510>] and for the Cox model [Held et al. (2016) <doi:10.1002/sim.7089>].

Easily construct prompts and associated logic for interacting with large language models (LLMs). tidyprompt introduces the concept of prompt wraps, which are building blocks that you can use to quickly turn a simple prompt into a complex one. Prompt wraps do not just modify the prompt text, but also add extraction and validation functions that will be applied to the response of the LLM. This ensures that the user gets the desired output. tidyprompt can add various features to prompts and their evaluation by LLMs, such as structured output, automatic feedback, retries, reasoning modes, autonomous R function calling, and R code generation and evaluation. It is designed to be compatible with any LLM provider that offers chat completion.

This package provides users a quick exploratory dive into common visualizations without writing a single line of code given the users data follows the Analysis Data Model (ADaM) standards put forth by the Clinical Data Interchange Standards Consortium (CDISC) <https://www.cdisc.org>. Prominent modules/ features of the application are the Table Generator, Population Explorer, and the Individual Explorer. The Table Generator allows users to drag and drop variables and desired statistics (frequencies, means, ANOVA, t-test, and other summary statistics) into bins that automagically create stunning tables with validated information. The Population Explorer offers various plots to visualize general trends in the population from various vantage points. Plot modules currently include scatter plot, spaghetti plot, box plot, histogram, means plot, and bar plot. Each plot type allows the user to plot uploaded variables against one another, and dissect the population by filtering out certain subjects. Last, the Individual Explorer establishes a cohesive patient narrative, allowing the user to interact with patient metrics (params) by visit or plotting important patient events on a timeline. All modules allow for concise filtering & downloading bulk outputs into html or pdf formats to save for later.

Provide functions to estimate the coefficients in high-dimensional linear regressions via a tuning-free and robust approach. The method was published in Wang, L., Peng, B., Bradic, J., Li, R. and Wu, Y. (2020), "A Tuning-free Robust and Efficient Approach to High-dimensional Regression", Journal of the American Statistical Association, 115:532, 1700-1714(JASAâ s discussion paper), <doi:10.1080/01621459.2020.1840989>. See also Wang, L., Peng, B., Bradic, J., Li, R. and Wu, Y. (2020), "Rejoinder to â A tuning-free robust and efficient approach to high-dimensional regression". Journal of the American Statistical Association, 115, 1726-1729, <doi:10.1080/01621459.2020.1843865>; Peng, B. and Wang, L. (2015), "An Iterative Coordinate Descent Algorithm for High-Dimensional Nonconvex Penalized Quantile Regression", Journal of Computational and Graphical Statistics, 24:3, 676-694, <doi:10.1080/10618600.2014.913516>; Clémençon, S., Colin, I., and Bellet, A. (2016), "Scaling-up empirical risk minimization: optimization of incomplete u-statistics", The Journal of Machine Learning Research, 17(1):2682â 2717; Fan, J. and Li, R. (2001), "Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties", Journal of the American Statistical Association, 96:456, 1348-1360, <doi:10.1198/016214501753382273>.

This package provides a coherent interface to multiple modelling tools for fitting trends along with a standardised approach for generating confidence and prediction intervals.

Estimators for semi-parametric linear regression models with truncated response variables (fixed truncation point). The estimators implemented are the Symmetrically Trimmed Least Squares (STLS) estimator introduced by Powell (1986) <doi:10.2307/1914308>, the Quadratic Mode (QME) estimator introduced by Lee (1993) <doi:10.1016/0304-4076(93)90056-B>, and the Left Truncated (LT) estimator introduced by Karlsson (2006) <doi:10.1007/s00184-005-0023-x>.

It performs the smoothing approach provided by penalized least squares for univariate and bivariate time series, as proposed by Guerrero (2007) and Gerrero et al. (2017). This allows to estimate the time series trend by controlling the amount of resulting (joint) smoothness. --- Guerrero, V.M (2007) <DOI:10.1016/j.spl.2007.03.006>. Guerrero, V.M; Islas-Camargo, A. and Ramirez-Ramirez, L.L. (2017) <DOI:10.1080/03610926.2015.1133826>.

Fast, reproducible detection and quantitative analysis of tertiary lymphoid structures (TLS) in multiplexed tissue imaging. Implements Independent Component Analysis Trace (ICAT) index, local Ripley's K scanning, automated K Nearest Neighbor (KNN)-based TLS detection, and T-cell clusters identification as described in Amiryousefi et al. (2025) <doi:10.1101/2025.09.21.677465>.

This package provides a tidy approach to analysis of biological sequences. All processing and data-storage functions are heavily optimized to allow the fastest and most efficient data storage.

Tidal analysis of evenly spaced observed time series (time step 1 to 60 min) with or without shorter gaps using the harmonic representation of inequalities. The analysis should preferably cover an observation period of at least 19 years. For shorter periods low frequency constituents are not taken into account, in accordance with the Rayleigh-Criterion. The main objective of this package is to synthesize or predict a tidal time series.

Easy visualization, wrangling, and feature engineering of time series data for forecasting and machine learning prediction. Consolidates and extends time series functionality from packages including dplyr', stats', xts', forecast', slider', padr', recipes', and rsample'.