This package provides a system for fitting Gompertz Curve in a Time Series Data.

Estimates generalized additive latent and mixed models using maximum marginal likelihood, as defined in Sorensen et al. (2023) <doi:10.1007/s11336-023-09910-z>, which is an extension of Rabe-Hesketh and Skrondal (2004)'s unifying framework for multilevel latent variable modeling <doi:10.1007/BF02295939>. Efficient computation is done using sparse matrix methods, Laplace approximation, and automatic differentiation. The framework includes generalized multilevel models with heteroscedastic residuals, mixed response types, factor loadings, smoothing splines, crossed random effects, and combinations thereof. Syntax for model formulation is close to lme4 (Bates et al. (2015) <doi:10.18637/jss.v067.i01>) and PLmixed (Rockwood and Jeon (2019) <doi:10.1080/00273171.2018.1516541>).

Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the gimap package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.

R function gawdis() produces multi-trait dissimilarity with more uniform contributions of different traits. de Bello et al. (2021) <doi:10.1111/2041-210X.13537> presented the approach based on minimizing the differences in the correlation between the dissimilarity of each trait, or groups of traits, and the multi-trait dissimilarity. This is done using either an analytic or a numerical solution, both available in the function.

When comparing discrete data mini bubble plots allow displaying more information than traditional bubble plots via colour, shape or labels. Exact overlapping coordinates will be transformed so they surround the original point circularly without overlapping. This is implemented as a position_surround() function for ggplot2'.

Splits date and time of day components from continuous datetime objects, then plots them using grammar of graphics ('ggplot2'). Plots can also be decorated with solar cycle information (e.g., sunset, sunrise, etc.). This is useful for visualising data that are associated with the solar cycle.

Allows for easy creation of diagnostic plots for a variety of model objects using the Grammar of Graphics. Provides functionality for both individual diagnostic plots and an array of four standard diagnostic plots.

This package implements a geographically weighted partial correlation which is an extension from gwss() function in the GWmodel package (Percival and Tsutsumida (2017) <doi:10.1553/giscience2017_01_s36>).

Optimal design analysis algorithms for any study design that can be represented or modelled as a generalised linear mixed model including cluster randomised trials, cohort studies, spatial and temporal epidemiological studies, and split-plot designs. See <https://github.com/samuel-watson/glmmrBase/blob/master/README.md> for a detailed manual on model specification. A detailed discussion of the methods in this package can be found in Watson, Hemming, and Girling (2023) <doi:10.1177/09622802231202379>.

Several methods may be found for selecting a subset of regressors from a set of k candidate variables in multiple linear regression. One possibility is to evaluate all possible regression models and comparing them using Mallows's Cp statistic (Cp) according to Gilmour original study. Full model is calculated, all possible combinations of regressors are generated, adjusted Cp for each submodel are computed, and the submodel with the minimum adjusted value Cp (ModelMin) is calculated. To identify the final model, the package applies a sequence of hypothesis tests on submodels nested within ModelMin, following the approach outlined in Gilmour's original paper. For more details see the help of the function final_model() and the original study (1996) <doi:10.2307/2348411>.

The Gaussian Interval Plot (GIplot) is a pictorial representation of the mean and the standard deviation of a quantitative variable. It also flags potential outliers (together with their frequencies) that are c standard deviations away from the mean.

Facilitates the citation of R packages used in analysis projects. Scans project for packages used, gets their citations, and produces a document with citations in the preferred bibliography format, ready to be pasted into reports or manuscripts. Alternatively, grateful can be used directly within an R Markdown or Quarto document.

This package provides a collection of functions useful in (vegetation) community analyses and ordinations. Includes automatic species selection for ordination diagrams, NMDS stress/scree plots, species response curves, merging of taxa as well as calculation and sorting of synoptic tables.

This package provides a Bayesian model selection approach for generalized linear mixed models. Currently, GLMMselect can be used for Poisson GLMM and Bernoulli GLMM. GLMMselect can select fixed effects and random effects simultaneously. Covariance structures for the random effects are a product of a unknown scalar and a known semi-positive definite matrix. GLMMselect can be widely used in areas such as longitudinal studies, genome-wide association studies, and spatial statistics. GLMMselect is based on Xu, Ferreira, Porter, and Franck (202X), Bayesian Model Selection Method for Generalized Linear Mixed Models, Biometrics, under review.

Collection of functions to enhance ggplot2 and ggiraph'. Provides functions for exploratory plots. All plot can be a static plot or an interactive plot using ggiraph'.

This package provides a function to retrieve the system timezone on Unix systems which has been found to find an answer when Sys.timezone() has failed. It is based on an answer by Duane McCully posted on StackOverflow', and adapted to be callable from R. The package also builds on Windows, but just returns NULL.

These Rcpp'-based functions compute the efficient score statistics for grouped time-to-event data (Prentice and Gloeckler, 1978), with the optional inclusion of baseline covariates. Functions for estimating the parameter of interest and nuisance parameters, including baseline hazards, using maximum likelihood are also provided. A parallel set of functions allow for the incorporation of family structure of related individuals (e.g., trios). Note that the current implementation of the frailty model (Ripatti and Palmgren, 2000) is sensitive to departures from model assumptions, and should be considered experimental. For these data, the exact proportional-hazards-model-based likelihood is computed by evaluating multiple variable integration. The integration is accomplished using the Cuba library (Hahn, 2005), and the source files are included in this package. The maximization process is carried out using Brent's algorithm, with the C++ code file from John Burkardt and John Denker (Brent, 2002).

Reads data collected from wearable acceleratometers as used in sleep and physical activity research. Currently supports file formats: binary data from GENEActiv <https://activinsights.com/>, .bin-format from GENEA devices (not for sale), and .cwa-format from Axivity <https://axivity.com>. Further, it has functions for reading text files with epoch level aggregates from Actical', Fitbit', Actiwatch', ActiGraph', and PhilipsHealthBand'. Primarily designed to complement R package GGIR <https://CRAN.R-project.org/package=GGIR>.

Generator and density function for the Generalized Inverse Gaussian (GIG) distribution.

This package implements the gene-based segregation test(GESE) and the weighted GESE test for identifying genes with causal variants of large effects for family-based sequencing data. The methods are described in Qiao, D. Lange, C., Laird, N.M., Won, S., Hersh, C.P., et al. (2017). <DOI:10.1002/gepi.22037>. Gene-based segregation method for identifying rare variants for family-based sequencing studies. Genet Epidemiol 41(4):309-319. More details can be found at <http://scholar.harvard.edu/dqiao/gese>.

Makes the Genepop software available in R. This software implements a mixture of traditional population genetic methods and some more focused developments: it computes exact tests for Hardy-Weinberg equilibrium, for population differentiation and for genotypic disequilibrium among pairs of loci; it computes estimates of F-statistics, null allele frequencies, allele size-based statistics for microsatellites, etc.; and it performs analyses of isolation by distance from pairwise comparisons of individuals or population samples.

Generates experiments - simulating structured or experimental data as: completely randomized design, randomized block design, latin square design, factorial and split-plot experiments (Ferreira, 2008, ISBN:8587692526; Naes et al., 2007 <doi:10.1002/qre.841>; Rencher et al., 2007, ISBN:9780471754985; Montgomery, 2001, ISBN:0471316490).

This package provides R functions to access the API of the project and repository management web application GitLab'. For many common tasks (repository file access, issue assignment and status, commenting) convenience wrappers are provided, and in addition the full API can be used by specifying request locations. GitLab is open-source software and can be self-hosted or used on <https://about.gitlab.com>.

We consider the ultrahigh-dimensional and error-prone data. Our goal aims to estimate the precision matrix and identify the graphical structure of the random variables with measurement error corrected. We further adopt the estimated precision matrix to the linear discriminant function to do classification for multi-label classes.