The main function, plot_GMM, is used for plotting output from Gaussian mixture models (GMMs), including both densities and overlaying mixture weight component curves from the fit GMM. The package also include the function, plot_cut_point, which plots the cutpoint (mu) from the GMM over a histogram of the distribution with several color options. Finally, the package includes the function, plot_mix_comps, which is used in the plot_GMM function, and can be used to create a custom plot for overlaying mixture component curves from GMMs. For the plot_mix_comps function, usage most often will be specifying the "fun" argument within "stat_function" in a ggplot2 object.

This package provides functions to create high-quality, publication-ready plots for numeric and categorical data, including bar plots, violin plots, boxplots, line plots, error bars, correlation plots, linear model plots, odds ratio plots, and normality plots.

Single arm phase 2 oncology trial. For more details see P. Gao (2024) <doi:10.1080/10543406.2024.2341673>.

The PBIB designs are important type of incomplete block designs having wide area of their applications for example in agricultural experiments, in plant breeding, in sample surveys etc. This package constructs various series of PBIB designs and assists in checking all the necessary conditions of PBIB designs and the association scheme on which these designs are based on. It also assists in calculating the efficiencies of PBIB designs with any number of associate classes. The package also constructs Youden-m square designs which are Row-Column designs for the two-way elimination of heterogeneity. The incomplete columns of these Youden-m square designs constitute PBIB designs. With the present functionality, the package will be of immense importance for the researchers as it will help them to construct PBIB designs, to check if their PBIB designs and association scheme satisfy various necessary conditions for the existence, to calculate the efficiencies of PBIB designs based on any association scheme and to construct Youden-m square designs for the two-way elimination of heterogeneity. R. C. Bose and K. R. Nair (1939) <http://www.jstor.org/stable/40383923>.

There are two main functions: (1) To estimate the power of testing for linkage using an affected sib pair design, as a function of the recurrence risk ratios. We will use analytical power formulae as implemented in R. These are based on a Mathematica notebook created by Martin Farrall. (2) To examine how the power of the transmission disequilibrium test (TDT) depends on the disease allele frequency, the marker allele frequency, the strength of the linkage disequilibrium, and the magnitude of the genetic effect. We will use an R program that implements the power formulae of Abel and Muller-Myhsok (1998). These formulae allow one to quickly compute power of the TDT approach under a variety of different conditions. This R program was modeled on Martin Farrall's Mathematica notebook.

Stochastic block model used for dynamic graphs represented by Poisson processes. To model recurrent interaction events in continuous time, an extension of the stochastic block model is proposed where every individual belongs to a latent group and interactions between two individuals follow a conditional inhomogeneous Poisson process with intensity driven by the individualsâ latent groups. The model is shown to be identifiable and its estimation is based on a semiparametric variational expectation-maximization algorithm. Two versions of the method are developed, using either a nonparametric histogram approach (with an adaptive choice of the partition size) or kernel intensity estimators. The number of latent groups can be selected by an integrated classification likelihood criterion. Y. Baraud and L. Birgé (2009). <doi:10.1007/s00440-007-0126-6>. C. Biernacki, G. Celeux and G. Govaert (2000). <doi:10.1109/34.865189>. M. Corneli, P. Latouche and F. Rossi (2016). <doi:10.1016/j.neucom.2016.02.031>. J.-J. Daudin, F. Picard and S. Robin (2008). <doi:10.1007/s11222-007-9046-7>. A. P. Dempster, N. M. Laird and D. B. Rubin (1977). <http://www.jstor.org/stable/2984875>. G. Grégoire (1993). <http://www.jstor.org/stable/4616289>. L. Hubert and P. Arabie (1985). <doi:10.1007/BF01908075>. M. Jordan, Z. Ghahramani, T. Jaakkola and L. Saul (1999). <doi:10.1023/A:1007665907178>. C. Matias, T. Rebafka and F. Villers (2018). <doi:10.1093/biomet/asy016>. C. Matias and S. Robin (2014). <doi:10.1051/proc/201447004>. H. Ramlau-Hansen (1983). <doi:10.1214/aos/1176346152>. P. Reynaud-Bouret (2006). <doi:10.3150/bj/1155735930>.

Lightweight, GPU-accelerated bioinformatics visualization widgets (volcano plots, expression and clustered heatmaps, dot plots, stacked violins, embeddings, spatial tissue maps, oncoprints, protein domain lollipops, Kaplan-Meier curves, mutational signature profiles, UpSet plots, treemaps, networks and Hi-C contact matrices) backed by a shared JavaScript core and exposed to R through htmlwidgets'. Designed for large datasets that render smoothly in the browser, the RStudio Viewer, R Markdown, Quarto and Shiny.

Permute treatment labels for taxa and environmental gradients to generate an empirical distribution of change points. This is an extension for the TITAN2 package <https://cran.r-project.org/package=TITAN2>.

Hidden Markov Models are useful for modeling sequential data. This package provides several functions implemented in C++ for explaining the algorithms used for Hidden Markov Models (forward, backward, decoding, learning).

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as Monolix', NONMEM', and nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with Monolix', pmxNODE interfaces with MonolixSuite via the lixoftConnectors package. The lixoftConnectors package is distributed with MonolixSuite (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Read and write GraphPad Prism .pzfx files in R.

Complex graphical representations of data are best explored using interactive elements. parcats adds interactive graphing capabilities to the easyalluvial package. The plotly.js parallel categories diagrams offer a good framework for creating interactive flow graphs that allow manual drag and drop sorting of dimensions and categories, highlighting single flows and displaying mouse over information. The plotly.js dependency is quite heavy and therefore is outsourced into a separate package.

This package provides a collection of functions to simulate, estimate and forecast a wide range of regression based dynamic models for positive time series. This package implements the results presented in Prass, T.S.; Pumi, G.; Taufemback, C.G. and Carlos, J.H. (2025). "Positive time series regression models: theoretical and computational aspects". Computational Statistics 40, 1185â 1215. <doi:10.1007/s00180-024-01531-z>.

Can be used to carry out permutation based gene expression pathway analysis. This work was supported by a National Institute of Allergy and Infectious Disease/National Institutes of Health contract (No. HHSN272200900059C).

This package provides tools for loading and processing passive acoustic data. Read in data that has been processed in Pamguard (<https://www.pamguard.org/>), apply a suite processing functions, and export data for reports or external modeling tools. Parameter calculations implement methods by Oswald et al (2007) <doi:10.1121/1.2743157>, Griffiths et al (2020) <doi:10.1121/10.0001229> and Baumann-Pickering et al (2010) <doi:10.1121/1.3479549>.

Investigate (analytically or visually) the inputs and outputs of probabilistic analyses of health economic models using standard health economic visualisation and metamodelling methods.

This package provides functions to estimate and plot smooth or linear population trends, or population indices, from animal or plant count survey data.

Structured fusion Lasso penalized estimation of multi-state models with the penalty applied to absolute effects and absolute effect differences (i.e., effects on transition-type specific hazard rates).

Efficient statistical inference of two-sample MR (Mendelian Randomization) analysis. It can account for the correlated instruments and the horizontal pleiotropy, and can provide the accurate estimates of both causal effect and horizontal pleiotropy effect as well as the two corresponding p-values. There are two main functions in the PPMR package. One is PMR_individual() for individual level data, the other is PMR_summary() for summary data.

This package provides functions to make board game graphics with the ggplot2', grid', rayrender', rayvertex', and rgl packages. Specializes in game diagrams, animations, and "Print & Play" layouts for the piecepack <https://www.ludism.org/ppwiki> but can make graphics for other board game systems. Includes configurations for several public domain game systems such as checkers, (double-18) dominoes, go, piecepack', playing cards, etc.

Aims to utilize model-based clustering (unsupervised) for high dimensional and ultra large data, especially in a distributed manner. The code employs pbdMPI to perform a expectation-gathering-maximization algorithm for finite mixture Gaussian models. The unstructured dispersion matrices are assumed in the Gaussian models. The implementation is default in the single program multiple data programming model. The code can be executed through pbdMPI and MPI implementations such as OpenMPI and MPICH'. See the High Performance Statistical Computing website <https://snoweye.github.io/hpsc/> for more information, documents and examples.

Multi-state models are essential tools in longitudinal data analysis. One primary goal of these models is the estimation of transition probabilities, a critical metric for predicting clinical prognosis across various stages of diseases or medical conditions. Traditionally, inference in multi-state models relies on the Aalen-Johansen (AJ) estimator which is consistent under the Markov assumption. However, in many practical applications, the Markovian nature of the process is often not guaranteed, limiting the applicability of the AJ estimator in more complex scenarios. This package extends the landmark Aalen-Johansen estimator (Putter, H, Spitoni, C (2018) <doi:10.1177/0962280216674497>) incorporating presmoothing techniques described by Soutinho, Meira-Machado and Oliveira (2020) <doi:10.1080/03610918.2020.1762895>, offering a robust alternative for estimating transition probabilities in non-Markovian multi-state models with multiple states and potential reversible transitions.

This package provides a set of tools to install, manage and run several Pandoc versions.

Analyzis and filtering of phylogenomics datasets. It takes an input either a collection of gene trees (then transformed to matrices) or directly a collection of gene matrices and performs an iterative process to identify what species in what genes are outliers, and whose elimination significantly improves the concordance between the input matrices. The methods builds upon the Distatis approach (Abdi et al. (2005) <doi:10.1101/2021.09.08.459421>), a generalization of classical multidimensional scaling to multiple distance matrices.