Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>, Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>, Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>, Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>, Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Visualize the partitions of simple decision trees, involving one or two predictors, on the scale of the original data. Provides an intuitive alternative to traditional tree diagrams, by visualizing how a decision tree divides the predictor space in a simple 2D plot alongside the original data. The parttree package supports both classification and regression trees from rpart and partykit', as well as trees produced by popular frontend systems like tidymodels and mlr3'. Visualization methods are provided for both base R graphics and ggplot2'.

Offers a comprehensive collection of penguin-related datasets suitable for descriptive statistics, hypothesis testing, and experimental design. Derived from open ecological and biological sources such as Palmer Station studies, the package integrates datasets covering adult morphology, clutch size, blood isotope composition, and heart rate. It is designed for researchers, students, and educators to explore statistical methods including ANOVA, regression, multivariate analysis, and design of experiments in an accessible and reproducible context.

This package provides a Shiny Web Application to predict and visualize concentrations of pharmaceuticals in the aqueous environment. Jagadeesan K., Barden R. and Kasprzyk-Hordern B. (2022) <https://www.ssrn.com/abstract=4306129>.

Power analysis and sample size determination for moderation, mediation, and moderated mediation in models fitted by structural equation modelling using the lavaan package by Rosseel (2012) <doi:10.18637/jss.v048.i02> or by multiple regression. The package manymome by Cheung and Cheung (2024) <doi:10.3758/s13428-023-02224-z> is used to specify the indirect paths or conditional indirect paths to be tested.

This package provides a framework for defining pipelines of functions for applying data transformations, model estimation and inverse-transformations, resulting in predicted value generation (or model-scoring) functions that automatically apply the entire pipeline of functions required to go from input to predicted output.

Power estimation and sample size calculation for 10X Visium Spatial Transcriptomics data to detect differential expressed genes between two conditions based on bootstrap resampling. See Shui et al. (2025) <doi:10.1371/journal.pcbi.1013293> for method details.

This package provides a tool, grammar, and standard to represent and exchange R package source code as text files. Converts one or more source packages to a text file and restores the package structures from the file.

This package provides a focused implementation of the Public Suffix List (PSL). Bundles a reproducible, pinned PSL snapshot and implements the official prevailing-rule algorithm to answer public-suffix (eTLD) and registrable-domain (eTLD+1) queries. Distinguishes ICANN and PRIVATE rule sections, accepts Unicode and ASCII hostnames via punycoder canonicalization, and supports an explicit, validated offline refresh path. The matcher is compiled with cpp11 and requires no external system library. Used as the PSL engine by the rurl package.

This package contains various tools for conveniently downloading and editing taxon-specific datasets from the Paleobiology Database <https://paleobiodb.org>, extracting information on abundance, temporal distribution of subtaxa and taxonomic diversity through deep time, and visualizing these data in relation to phylogeny and stratigraphy.

Code to identify functional enrichments across diverse taxa in phylogenetic tree, particularly where these taxa differ in abundance across samples in a non-random pattern. The motivation for this approach is to identify microbial functions encoded by diverse taxa that are at higher abundance in certain samples compared to others, which could indicate that such functions are broadly adaptive under certain conditions. See GitHub repository for tutorial and examples: <https://github.com/gavinmdouglas/POMS/wiki>. Citation: Gavin M. Douglas, Molly G. Hayes, Morgan G. I. Langille, Elhanan Borenstein (2022) <doi:10.1093/bioinformatics/btac655>.

This package provides classes for analysing and implementing equity portfolios, including routines for generating tradelists and calculating exposures to user-specified risk factors.

This package provides a network-based systems biology tool for flexible identification of phenotype-specific subpathways in the cancer gene expression data with multiple categories (such as multiple subtype or developmental stages of cancer). Subtype Set Enrichment Analysis (SubSEA) and Dynamic Changed Subpathway Analysis (DCSA) are developed to flexible identify subtype specific and dynamic changed subpathways respectively. The operation modes include extraction of subpathways from biological pathways, inference of subpathway activities in the context of gene expression data, identification of subtype specific subpathways with SubSEA, identification of dynamic changed subpathways associated with the cancer developmental stage with DCSA, and visualization of the activities of resulting subpathways by using box plots and heat maps. Its capabilities render the tool could find the specific abnormal subpathways in the cancer dataset with multi-phenotype samples.

Function to read PX-Web data into R via API. The example code reads data from the three national statistical institutes, Statistics Norway, Statistics Sweden and Statistics Finland.

This package provides a suite of likelihood ratio test based methods to use in pharmacovigilance. Contains various testing and post-processing functions.

Supports the creation of burndown charts and gantt diagrams.

Spatial estimation of a prevalence surface or a relative risks surface, using data from a Demographic and Health Survey (DHS) or an analog survey, see Larmarange et al. (2011) <doi:10.4000/cybergeo.24606>.

This package implements the Bi-objective Lexicographical Classification method and Performance Assessment Ratio at 10% metric for algorithm classification. Constructs matrices representing algorithm performance under multiple criteria, facilitating decision-making in algorithm selection and evaluation. Analyzes and compares algorithm performance based on various metrics to identify the most suitable algorithms for specific tasks. This package includes methods for algorithm classification and evaluation, with examples provided in the documentation. Carvalho (2019) presents a statistical evaluation of algorithmic computational experimentation with infeasible solutions <doi:10.48550/arXiv.1902.00101>. Moreira and Carvalho (2023) analyze power in preprocessing methodologies for datasets with missing values <doi:10.1080/03610918.2023.2234683>.

This package provides functions for bootstrapping the power of ANOVA designs based on estimated means and standard deviations of the conditions. Please refer to the documentation of the boot.power.anova() function for further details.

Analyse prescription drug deliveries to calculate several indicators of polypharmacy corresponding to the various definitions found in the literature. Bjerrum, L., Rosholm, J. U., Hallas, J., & Kragstrup, J. (1997) <doi:10.1007/s002280050329>. Chan, D.-C., Hao, Y.-T., & Wu, S.-C. (2009a) <doi:10.1002/pds.1712>. Fincke, B. G., Snyder, K., Cantillon, C., Gaehde, S., Standring, P., Fiore, L., ... Gagnon, D.R. (2005) <doi:10.1002/pds.966>. Hovstadius, B., Astrand, B., & Petersson, G. (2009) <doi:10.1186/1472-6904-9-11>. Hovstadius, B., Astrand, B., & Petersson, G. (2010) <doi:10.1002/pds.1921>. Kennerfalk, A., Ruigómez, A., Wallander, M.-A., Wilhelmsen, L., & Johansson, S. (2002) <doi:10.1345/aph.1A226>. Masnoon, N., Shakib, S., Kalisch-Ellett, L., & Caughey, G. E. (2017) <doi:10.1186/s12877-017-0621-2>. Narayan, S. W., & Nishtala, P. S. (2015) <doi:10.1007/s40801-015-0020-y>. Nishtala, P. S., & Salahudeen, M. S. (2015) <doi:10.1159/000368191>. Park, H. Y., Ryu, H. N., Shim, M. K., Sohn, H. S., & Kwon, J. W. (2016) <doi:10.5414/cp202484>. Veehof, L., Stewart, R., Haaijer-Ruskamp, F., & Jong, B. M. (2000) <doi:10.1093/fampra/17.3.261>.

Efficient calculation of pseudo-ranks and (pseudo)-rank based test statistics. In case of equal sample sizes, pseudo-ranks and mid-ranks are equal. When used for inference mid-ranks may lead to paradoxical results. Pseudo-ranks are in general not affected by such a problem. See Happ et al. (2020, <doi:10.18637/jss.v095.c01>) for details.

This package provides functions for estimation and data generation for several piecewise lifetime distributions. The package implements the power piecewise Weibull model, which includes the piecewise Rayleigh and piecewise exponential models as special cases. See Feigl and Zelen (1965) <doi:10.2307/2528247> for methodological details.

Prism <https://prismjs.com/> is a lightweight, extensible syntax highlighter, built with modern web standards in mind. This package provides server-side rendering in R using V8 such that no JavaScript library is required in the resulting HTML documents. Over 400 languages are supported.

Early generation breeding trials are to be conducted in multiple environments where it may not be possible to replicate all the lines in each environment due to scarcity of resources. For such situations, partially replicated (p-Rep) designs have wide application potential as only a proportion of the test lines are replicated at each environment. A collection of several utility functions related to p-Rep designs have been developed. Here, the package contains six functions for a complete stepwise analytical study of these designs. Five functions pRep1(), pRep2(), pRep3(), pRep4() and pRep5(), are used to generate five new series of p-Rep designs and also compute average variance factors and canonical efficiency factors of generated designs. A fourth function NCEV() is used to generate incidence matrix (N), information matrix (C), canonical efficiency factor (E) and average variance factor (V). This function is general in nature and can be used for studying the characterization properties of any block design. A construction procedure for p-Rep designs was given by Williams et al.(2011) <doi:10.1002/bimj.201000102> which was tedious and time consuming. Here, in this package, five different methods have been given to generate p-Rep designs easily.