Convert Ensembl gene identifiers from Genotype-Tissue Expression (GTEx) data to identifiers in other annotation systems, including Entrez', HGNC', and UniProt'.

This package creates presentation-ready tables summarizing data sets, regression models, and more. The code to create the tables is concise and highly customizable. Data frames can be summarized with any function, e.g. mean(), median(), even user-written functions. Regression models are summarized and include the reference rows for categorical variables. Common regression models, such as logistic regression and Cox proportional hazards regression, are automatically identified and the tables are pre-filled with appropriate column headers.

Finds subsets of sets of genotypes with a high Heterozygosity, and Mean of Transformed Kinships (MTK), measures that can indicate a subset would be beneficial for rare-trait discovery and genome-wide association scanning, respectively.

Flexible and robust estimation and inference of Generalised Autoregressive Conditional Heteroscedasticity (GARCH) models with covariates ('X') based on the results by Francq and Thieu (2019) <doi:10.1017/S0266466617000512>. Coefficients can straightforwardly be set to zero by omission, and quasi maximum likelihood methods ensure estimates are generally consistent and inference valid, even when the standardised innovations are non-normal and/or dependent over time. See <doi:10.32614/RJ-2021-057> for an overview of the package.

Geoms for placing arrowheads at multiple points along a segment, not just at the end; position function to shift starts and ends of arrows to avoid exactly intersecting points.

Understanding spatial association is essential for spatial statistical inference, including factor exploration and spatial prediction. Geographically optimal similarity (GOS) model is an effective method for spatial prediction, as described in Yongze Song (2022) <doi:10.1007/s11004-022-10036-8>. GOS was developed based on the geographical similarity principle, as described in Axing Zhu (2018) <doi:10.1080/19475683.2018.1534890>. GOS has advantages in more accurate spatial prediction using fewer samples and critically reduced prediction uncertainty.

This package provides a general, flexible framework for estimating parameters and empirical sandwich variance estimator from a set of unbiased estimating equations (i.e., M-estimation in the vein of Stefanski & Boos (2002) <doi:10.1198/000313002753631330>). All examples from Stefanski & Boos (2002) are published in the corresponding Journal of Statistical Software paper "The Calculus of M-Estimation in R with geex" by Saul & Hudgens (2020) <doi:10.18637/jss.v092.i02>. Also provides an API to compute finite-sample variance corrections.

Kernel regularized least squares, also known as kernel ridge regression, is a flexible machine learning method. This package implements this method by providing a smooth term for use with mgcv and uses random sketching to facilitate scalable estimation on large datasets. It provides additional functions for calculating marginal effects after estimation and for use with ensembles ('SuperLearning'), double/debiased machine learning ('DoubleML'), and robust/clustered standard errors ('sandwich'). Chang and Goplerud (2024) <doi:10.1017/pan.2023.27> provide further details.

This package provides publication-ready volcano plots for visualizing differential expression results, commonly used in RNA-seq and similar analyses. This tool helps create high-quality visual representations of data using the ggplot2 framework Wickham (2016) <doi:10.1007/978-3-319-24277-4>.

This package provides a network-based gene weighting algorithm for pathway enrichment analysis, using either RNA-seq or microarray data. Zhaoyuan Fang, Weidong Tian and Hongbin Ji (2012) <doi:10.1038/cr.2011.149>.

This package implements the Goldilocks adaptive trial design for a time to event outcome using a piecewise exponential model and conjugate Gamma prior distributions. The method closely follows the article by Broglio and colleagues <doi:10.1080/10543406.2014.888569>, which allows users to explore the operating characteristics of different trial designs.

This package provides a ggplot2 extension that adds specialised arrow geometry layers. It offers more arrow options than the standard grid arrows that are built-in many line-based geom layers.

This package implements readers and writers for file formats associated with genetics data. Reading and writing Plink BED/BIM/FAM and GCTA binary GRM formats is fully supported, including a lightning-fast BED reader and writer implementations. Other functions are readr wrappers that are more constrained, user-friendly, and efficient for these particular applications; handles Plink and Eigenstrat tables (FAM, BIM, IND, and SNP files). There are also make functions for FAM and BIM tables with default values to go with simulated genotype data.

This package provides functions for implementing the Generalized Bayesian Optimal Phase II (G-BOP2) design using various Particle Swarm Optimization (PSO) algorithms, including: - PSO-Default, based on Kennedy and Eberhart (1995) <doi:10.1109/ICNN.1995.488968>, "Particle Swarm Optimization"; - PSO-Quantum, based on Sun, Xu, and Feng (2004) <doi:10.1109/ICCIS.2004.1460396>, "A Global Search Strategy of Quantum-Behaved Particle Swarm Optimization"; - PSO-Dexp, based on Stehlà k et al. (2024) <doi:10.1016/j.asoc.2024.111913>, "A Double Exponential Particle Swarm Optimization with Non-Uniform Variates as Stochastic Tuning and Guaranteed Convergence to a Global Optimum with Sample Applications to Finding Optimal Exact Designs in Biostatistics"; - and PSO-GO.

The gamma-Orthogonal Matching Pursuit (gamma-OMP) is a recently suggested modification of the OMP feature selection algorithm for a wide range of response variables. The package offers many alternative regression models, such linear, robust, survival, multivariate etc., including k-fold cross-validation. References: Tsagris M., Papadovasilakis Z., Lakiotaki K. and Tsamardinos I. (2018). "Efficient feature selection on gene expression data: Which algorithm to use?" BioRxiv. <doi:10.1101/431734>. Tsagris M., Papadovasilakis Z., Lakiotaki K. and Tsamardinos I. (2022). "The gamma-OMP algorithm for feature selection with application to gene expression data". IEEE/ACM Transactions on Computational Biology and Bioinformatics 19(2): 1214--1224. <doi:10.1109/TCBB.2020.3029952>.

Allows user to choose/gate a region on the plot and returns points within it.

Utilizes methods of the PyMongo Python library to initialize, insert and query GeoJson data (see <https://github.com/mongodb/mongo-python-driver> for more information on PyMongo'). Furthermore, it allows the user to validate GeoJson objects and to use the console for MongoDB (bulk) commands. The reticulate package provides the R interface to Python modules, classes and functions.

This package provides methods for fitting macroevolutionary models to phylogenetic trees Pennell (2014) <doi:10.1093/bioinformatics/btu181>.

This package provides functions and a graphical user interface for graphical described multiple test procedures.

Compute standard and generalized Nash Equilibria of non-cooperative games. Optimization methods available are nonsmooth reformulation, fixed-point formulation, minimization problem and constrained-equation reformulation. See e.g. Kanzow and Facchinei (2010), <doi:10.1007/s10479-009-0653-x>.

The accurate annotation of genes and Quantitative Trait Loci (QTLs) located within candidate markers and/or regions (haplotypes, windows, CNVs, etc) is a crucial step the most common genomic analyses performed in livestock, such as Genome-Wide Association Studies or transcriptomics. The Genomic Annotation in Livestock for positional candidate LOci (GALLO) is an R package designed to provide an intuitive and straightforward environment to annotate positional candidate genes and QTLs from high-throughput genetic studies in livestock. Moreover, GALLO allows the graphical visualization of gene and QTL annotation results, data comparison among different grouping factors (e.g., methods, breeds, tissues, statistical models, studies, etc.), and QTL enrichment in different livestock species including cattle, pigs, sheep, and chicken, among others.

Help to the occasional R user for synthesis and enhanced graphical visualization of redundancy analysis (RDA) and principal component analysis (PCA) methods and objects. Inputs are : data frame, RDA (package vegan') and PCA (package FactoMineR') objects. Outputs are : synthesized results of RDA, displayed in console and saved in tables ; displayed and saved objects of PCA graphic visualization of individuals and variables projections with multiple graphic parameters.

This package provides a ggplot2 extension providing an integrative framework for composable visualization, enabling the creation of complex multi-plot layouts such as insets, circular arrangements, and multi-panel compositions. Built on the grammar of graphics, it offers tools to align, stack, and nest plots, simplifying the construction of richly annotated figures for high-dimensional data contextsâ such as genomics, transcriptomics, and microbiome studiesâ by making it easy to link related plots, overlay clustering results, or highlight shared patterns.

Hierarchical Bayesian models. The package provides tools to fit two response time models, using the population-based Markov Chain Monte Carlo.