Facilitates building topology preserving maps for data analysis.

Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see Berg et al <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.

It is used to travel graphs, by using DFS and BFS to get the path from node to each leaf node. Depth first traversal(DFS) is a recursive algorithm for searching all the vertices of a graph or tree data structure. Traversal means visiting all the nodes of a graph. Breadth first traversal(BFS) algorithm is used to search a tree or graph data structure for a node that meets a set of criteria. It starts at the treeâ s root or graph and searches/visits all nodes at the current depth level before moving on to the nodes at the next depth level. Also, it provides the matrix which is reachable between each node. Implement reference about Baruch Awerbuch (1985) <doi:10.1016/0020-0190(85)90083-3>.

This package provides functions to access data from the US Department of Housing and Urban Development <https://www.huduser.gov/portal/dataset/fmr-api.html>.

This package provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented. The methods have been described in detail in Goeman et al (Biometrika 106, 841-856, 2019).

Bipartite graph-based hierarchical clustering, developed for pharmacogenomic datasets and datasets sharing the same data structure. The goal is to construct a hierarchical clustering of groups of samples based on association patterns between two sets of variables. In the context of pharmacogenomic datasets, the samples are cell lines, and the two sets of variables are typically expression levels and drug sensitivity values. For this method, sparse canonical correlation analysis from Lee, W., Lee, D., Lee, Y. and Pawitan, Y. (2011) <doi:10.2202/1544-6115.1638> is first applied to extract association patterns for each group of samples. Then, a nuclear norm-based dissimilarity measure is used to construct a dissimilarity matrix between groups based on the extracted associations. Finally, hierarchical clustering is applied.

The haversine is a function used to calculate the distance between a pair of latitude and longitude points while accounting for the assumption that the points are on a spherical globe. This package provides a fast, dataframe compatible, haversine function. For the first publication on the haversine calculation see Joseph de Mendoza y RÃ os (1795) <https://books.google.cat/books?id=030t0OqlX2AC> (In Spanish).

Texts for H.C. Andersens fairy tales, ready for text analysis. Fairy tales in German, Danish, English, Spanish and French.

Pfafstetter Hydrological Codes as cited in Verdin and Verdin (1999) <doi: 10.1016/S0022-1694(99)00011-6> are decoded for upstream or downstream queries.

Pure set data visualization approaches are often limited in scalability due to the combinatorial explosion of distinct set families as the number of sets under investigation increases. hierarchicalSets applies a set centric hierarchical clustering of the sets under investigation and uses this hierarchy as a basis for a range of scalable visual representations. hierarchicalSets is especially well suited for collections of sets that describe comparable comparable entities as it relies on the sets to have a meaningful relational structure.

Penalized regression for generalized linear models for measurement error problems (aka. errors-in-variables). The package contains a version of the lasso (L1-penalization) which corrects for measurement error (Sorensen et al. (2015) <doi:10.5705/ss.2013.180>). It also contains an implementation of the Generalized Matrix Uncertainty Selector, which is a version the (Generalized) Dantzig Selector for the case of measurement error (Sorensen et al. (2018) <doi:10.1080/10618600.2018.1425626>).

An implementation for high-dimensional time series analysis methods, including factor model for vector time series proposed by Lam and Yao (2012) <doi:10.1214/12-AOS970> and Chang, Guo and Yao (2015) <doi:10.1016/j.jeconom.2015.03.024>, martingale difference test proposed by Chang, Jiang and Shao (2023) <doi:10.1016/j.jeconom.2022.09.001>, principal component analysis for vector time series proposed by Chang, Guo and Yao (2018) <doi:10.1214/17-AOS1613>, cointegration analysis proposed by Zhang, Robinson and Yao (2019) <doi:10.1080/01621459.2018.1458620>, unit root test proposed by Chang, Cheng and Yao (2022) <doi:10.1093/biomet/asab034>, white noise test proposed by Chang, Yao and Zhou (2017) <doi:10.1093/biomet/asw066>, CP-decomposition for matrix time series proposed by Chang et al. (2023) <doi:10.1093/jrsssb/qkac011> and Chang et al. (2024) <doi:10.48550/arXiv.2410.05634>, and statistical inference for spectral density matrix proposed by Chang et al. (2022) <doi:10.48550/arXiv.2212.13686>.

Simulates stochastic hybrid models for transmission of infectious diseases in dynamic networks. It is a metapopulation model in which each node in the network is a sub-population and disease spreads within nodes and among them, combining two approaches: stochastic simulation algorithm (<doi:10.1146/annurev.physchem.58.032806.104637>) and individual-based approach, respectively. Equations that models spread within nodes are customizable and there are two link types among nodes: migration and influence (commuting). More information in Fernando S. Marques, Jose H. H. Grisi-Filho, Marcos Amaku et al. (2020) <doi:10.18637/jss.v094.i06>.

This package provides a simple and time saving multiple linear regression function (OLS) with interpretation, optional bootstrapping, effect size calculation and all tested requirements.

Raster based flood modelling internally using hyd1d', an R package to interpolate 1d water level and gauging data. The package computes flood extent and duration through strategies originally developed for INFORM', an ArcGIS'-based hydro-ecological modelling framework. It does not provide a full, physical hydraulic modelling algorithm, but a simplified, near real time GIS approach for flood extent and duration modelling. Computationally demanding annual flood durations have been computed already and data products were published by Weber (2022) <doi:10.1594/PANGAEA.948042>.

Offers efficient algorithms for fitting regularization paths for lasso or elastic-net penalized regression models with Huber loss, quantile loss or squared loss. Reference: Congrui Yi and Jian Huang (2017) <doi:10.1080/10618600.2016.1256816>.

Probability functions and other utilities for the generalized Hermite distribution.

Tests for two high-dimensional population mean vectors. The user has the option to compute the asymptotic, the permutation or the bootstrap based p-value of the test. Some references are: Chen S.X. and Qin Y.L. (2010). <doi:10.1214/09-AOS716>, Cai T.T., Liu W., and Xia Y. (2014) <doi:10.1111/rssb.12034> and Yu X., Li D., Xue L. and Li, R. (2023) <doi:10.1080/01621459.2022.2061354>.

The seed germination process starts with water uptake by the seed and ends with the protrusion of radicle and plumule under varying temperatures and soil water potential. Hydrotime is a way to describe the relationship between water potential and seed germination rates at germination percentages. One important quantity before applying hydrotime modeling of germination percentages is to consider the proportion of viable seeds that could germinate under saturated conditions. This package can be used to apply correction factors at various water potentials before estimating parameters like stress tolerance, and uniformity of the hydrotime model. Three different distributions namely, Gaussian, Logistic, and Extreme value distributions have been considered to fit the model to the seed germination time course. Details can be found in Bradford (2002) <https://www.jstor.org/stable/4046371>, and Bradford and Still(2004) <https://www.jstor.org/stable/23433495>.

Add, share and manage annotations for Shiny applications and R Markdown documents via hypothes.is'.

Pre-made models that can be rapidly tailored to various chemicals and species using chemical-specific in vitro data and physiological information. These tools allow incorporation of chemical toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE") into bioinformatics, as described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>). Chemical-specific in vitro data characterizing toxicokinetics have been obtained from relatively high-throughput experiments. The chemical-independent ("generic") physiologically-based ("PBTK") and empirical (for example, one compartment) "TK" models included here can be parameterized with in vitro data or in silico predictions which are provided for thousands of chemicals, multiple exposure routes, and various species. High throughput toxicokinetics ("HTTK") is the combination of in vitro data and generic models. We establish the expected accuracy of HTTK for chemicals without in vivo data through statistical evaluation of HTTK predictions for chemicals where in vivo data do exist. The models are systems of ordinary differential equations that are developed in MCSim and solved using compiled (C-based) code for speed. A Monte Carlo sampler is included for simulating human biological variability (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) and propagating parameter uncertainty (Wambaugh et al., 2019 <doi:10.1093/toxsci/kfz205>). Empirically calibrated methods are included for predicting tissue:plasma partition coefficients and volume of distribution (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). These functions and data provide a set of tools for using IVIVE to convert concentrations from high-throughput screening experiments (for example, Tox21, ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK") (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

Programmatic interface to the Harmonized World Soil Database HWSD web services (<https://daac.ornl.gov/cgi-bin/dsviewer.pl?ds_id=1247>). Allows for easy downloads of HWSD soil data directly to your R workspace or your computer. Routines for both single pixel data downloads and gridded data are provided.

Events from individual hydrologic time series are extracted, and events are matched across multiple time series. The package has been applied in studies such as Wasko and Guo (2022) <doi:10.1002/hyp.14563> and Mohammadpour Khoie, Guo and Wasko (2025) <doi:10.1016/j.envsoft.2025.106521>.

The HURRECON model estimates wind speed, wind direction, enhanced Fujita scale wind damage, and duration of EF0 to EF5 winds as a function of hurricane location and maximum sustained wind speed. Results may be generated for a single site or an entire region. Hurricane track and intensity data may be imported directly from the US National Hurricane Center's HURDAT2 database. For details on the original version of the model written in Borland Pascal, see: Boose, Chamberlin, and Foster (2001) <doi:10.1890/0012-9615(2001)071[0027:LARIOH]2.0.CO;2> and Boose, Serrano, and Foster (2004) <doi:10.1890/02-4057>.