An implementation of the data processing and data analysis portion of a pipeline named the PepSAVI-MS which is currently under development by the Hicks laboratory at the University of North Carolina. The statistical analysis package presented herein provides a collection of software tools used to facilitate the prioritization of putative bioactive peptides from a complex biological matrix. Tools are provided to deconvolute mass spectrometry features into a single representation for each peptide charge state, filter compounds to include only those possibly contributing to the observed bioactivity, and prioritize these remaining compounds for those most likely contributing to each bioactivity data set.

This package provides various functions for retrieving and interpreting information from Pubmed via the API, <https://www.ncbi.nlm.nih.gov/home/develop/api/>.

The portmanteau local feature discriminant approach first identifies the local discriminant features and their differential structures, then constructs the discriminant rule by pooling the identified local features together. This method is applicable to high-dimensional matrix-variate data. See the paper by Xu, Luo and Chen (2023, <doi:10.1007/s13171-021-00255-2>).

Analyze spatial phylogenetic diversity patterns. Use your data on an evolutionary tree and geographic distributions of the terminal taxa to compute diversity and endemism metrics, test significance with null model randomization, analyze community turnover and biotic regionalization, and perform spatial conservation prioritizations. All functions support quantitative community data in addition to binary data.

Calculates seat allocation using the D-Hondt method, Sainte-Lague method, and Modified Sainte-Lague method, all commonly used in proportional representation electoral systems. For more information on these methods, see Michael Gallagher (1991)<doi:10.1016/0261-3794(91)90004-C>.

Plot marginal effects for interactions estimated from linear models.

This package contains a graphical user interface to generate the diagnostic plots proposed by Bauer (2005; <doi:10.1207/s15328007sem1204_1>), Pek & Chalmers (2015; <doi:10.1080/10705511.2014.937790>), and Pek, Chalmers, R. Kok, & Losardo (2015; <doi:10.3102/1076998615589129>) to investigate nonlinear bivariate relationships in latent regression models using structural equation mixture models (SEMMs).

Threshold model, panel version of Hylleberg et al. (1990) <DOI:10.1016/0304-4076(90)90080-D> seasonal unit root tests, and panel unit root test of Chang (2002) <DOI:10.1016/S0304-4076(02)00095-7>.

This package provides a suite of likelihood ratio test based methods to use in pharmacovigilance. Contains various testing and post-processing functions.

Generation of a chosen number of count, binary, ordinal, and continuous random variables, with specified correlations and marginal properties. The details of the method are explained in Demirtas (2012) <DOI:10.1002/sim.5362>.

This package implements methods to automate the Auer-Gervini graphical Bayesian approach for determining the number of significant principal components. Automation uses clustering, change points, or simple statistical models to distinguish "long" from "short" steps in a graph showing the posterior number of components as a function of a prior parameter. See <doi:10.1101/237883>.

This package provides tools for both single and batch image manipulation and analysis (Olivoto, 2022 <doi:10.1111/2041-210X.13803>) and phytopathometry (Olivoto et al., 2022 <doi:10.1007/S40858-021-00487-5>). The tools can be used for the quantification of leaf area, object counting, extraction of image indexes, shape measurement, object landmark identification, and Elliptical Fourier Analysis of object outlines (Claude (2008) <doi:10.1007/978-0-387-77789-4>). The package also provides a comprehensive pipeline for generating shapefiles with complex layouts and supports high-throughput phenotyping of RGB, multispectral, and hyperspectral orthomosaics. This functionality facilitates field phenotyping using UAV- or satellite-based imagery.

This package provides a set of functions to efficiently recognize and clean the continuous dorsal pattern of a female brown anole lizard (Anolis sagrei) traced from ImageJ', an open platform for scientific image analysis (see <https://imagej.net> for more information), and extract common features such as the pattern sinuosity indices, coefficient of variation, and max-min width.

This package provides a lightweight, dependency-free, and simplified implementation of the Pseudo-Expectation Gauss-Seidel (PEGS) algorithm. It fits the multivariate ridge regression model for genomic prediction Xavier and Habier (2022) <doi:10.1186/s12711-022-00730-w> and Xavier et al. (2025) <doi:10.1093/genetics/iyae179>, providing heritability estimates, genetic correlations, breeding values, and regression coefficient estimates for prediction. This package provides an alternative to the bWGR package by Xavier et al. (2019) <doi:10.1093/bioinformatics/btz794> by using LAPACK for its algebraic operations.

Calculates the periodogram of a time series, maximum-likelihood fits an Ornstein-Uhlenbeck state space (OUSS) null model and evaluates the statistical significance of periodogram peaks against the OUSS null hypothesis. The OUSS is a parsimonious model for stochastically fluctuating variables with linear stabilizing forces, subject to uncorrelated measurement errors. Contrary to the classical white noise null model for detecting cyclicity, the OUSS model can account for temporal correlations typically occurring in ecological and geological time series. Citation: Louca, Stilianos and Doebeli, Michael (2015) <doi:10.1890/14-0126.1>.

This package provides functions to measure Alpha, Beta and Gamma Proximity to Irreplaceability. The methods for Alpha and Beta irreplaceability were first described in: Baisero D., Schuster R. & Plumptre A.J. Redefining and Mapping Global Irreplaceability. Conservation Biology 2021;1-11. <doi:10.1111/cobi.13806>.

This package provides functions to fit point process models using the Palm likelihood. First proposed by Tanaka, Ogata, and Stoyan (2008) <DOI:10.1002/bimj.200610339>, maximisation of the Palm likelihood can provide computationally efficient parameter estimation for point process models in situations where the full likelihood is intractable. This package is chiefly focused on Neyman-Scott point processes, but can also fit the void processes proposed by Jones-Todd et al. (2019) <DOI:10.1002/sim.8046>. The development of this package was motivated by the analysis of capture-recapture surveys on which individuals cannot be identified---the data from which can conceptually be seen as a clustered point process (Stevenson, Borchers, and Fewster, 2019 <DOI:10.1111/biom.12983>). As such, some of the functions in this package are specifically for the estimation of cetacean density from two-camera aerial surveys.

We provide comprehensive draft data for major professional sports leagues, including the National Football League (NFL), National Basketball Association (NBA), and National Hockey League (NHL). It offers access to both historical and current draft data, allowing for detailed analysis and research on player biases and player performance. The package is useful for sports fans and researchers interested in identifying biases and trends within scouting reports. Created by web scraping data from leading websites that cover professional sports player scouting reports, the package allows users to filter and summarize data for analytical purposes. For further details on the methods used, please refer to Wickham (2022) "rvest: Easily Harvest (Scrape) Web Pages" <https://CRAN.R-project.org/package=rvest> and Harrison (2023) "RSelenium: R Bindings for Selenium WebDriver" <https://CRAN.R-project.org/package=RSelenium>.

The Phylogenetic Ornstein-Uhlenbeck Mixed Model (POUMM) allows to estimate the phylogenetic heritability of continuous traits, to test hypotheses of neutral evolution versus stabilizing selection, to quantify the strength of stabilizing selection, to estimate measurement error and to make predictions about the evolution of a phenotype and phenotypic variation in a population. The package implements combined maximum likelihood and Bayesian inference of the univariate Phylogenetic Ornstein-Uhlenbeck Mixed Model, fast parallel likelihood calculation, maximum likelihood inference of the genotypic values at the tips, functions for summarizing and plotting traces and posterior samples, functions for simulation of a univariate continuous trait evolution model along a phylogenetic tree. So far, the package has been used for estimating the heritability of quantitative traits in macroevolutionary and epidemiological studies, see e.g. Bertels et al. (2017) <doi:10.1093/molbev/msx246> and Mitov and Stadler (2018) <doi:10.1093/molbev/msx328>. The algorithm for parallel POUMM likelihood calculation has been published in Mitov and Stadler (2019) <doi:10.1111/2041-210X.13136>.

Translates beliefs into prior information in the form of Beta and Gamma distributions. It can be used for the generation of priors on the prevalence of disease and the sensitivity/specificity of diagnostic tests and any other binomial experiment.

This package provides a cohesive framework for the spectral and spatial analysis of colour described in Maia, Eliason, Bitton, Doucet & Shawkey (2013) <doi:10.1111/2041-210X.12069> and Maia, Gruson, Endler & White (2019) <doi:10.1111/2041-210X.13174>.

This package provides functions for reading, and in some cases writing, foreign files containing spectral data from spectrometers and their associated software, output from daylight simulation models in common use, and some spectral data repositories. As well as functions for exchange of spectral data with other R packages. Part of the r4photobiology suite, Aphalo P. J. (2015) <doi:10.19232/uv4pb.2015.1.14>.

R interface to PRIMME <https://www.cs.wm.edu/~andreas/software/>, a C library for computing a few eigenvalues and their corresponding eigenvectors of a real symmetric or complex Hermitian matrix, or generalized Hermitian eigenproblem. It can also compute singular values and vectors of a square or rectangular matrix. PRIMME finds largest, smallest, or interior singular/eigenvalues and can use preconditioning to accelerate convergence. General description of the methods are provided in the papers Stathopoulos (2010, <doi:10.1145/1731022.1731031>) and Wu (2017, <doi:10.1137/16M1082214>). See citation("PRIMME") for details.

Function pip3d() tests whether a point in 3D space is within, exactly on, or outside an enclosed surface defined by a triangular mesh. Function pip2d() tests whether a point in 2D space is within, exactly on, or outside a polygon. For a reference, see: Liu et al., A new point containment test algorithm based on preprocessing and determining triangles, Computer-Aided Design 42(12):1143-1150.