This package provides a coding assistant using Perplexity's Large Language Models <https://www.perplexity.ai/> API. A set of functions and RStudio add-ins that aim to help R developers.

This package provides access to the PlanScore Application Programming Interface (<https://github.com/PlanScore/PlanScore/blob/main/API.md>) for scoring redistricting plans. Allows for upload of plans from block assignment files and shape files. For shapes in memory, such as from sf or redist', it processes them to save and upload. Includes tools for tidying responses and saving output from the website.

This package provides a C++ backend for multivariate phylogenetic comparative models implemented in the R-package PCMBase'. Can be used in combination with PCMBase to enable fast and parallel likelihood calculation. Implements the pruning likelihood calculation algorithm described in Mitov et al. (2020) <doi:10.1016/j.tpb.2019.11.005>. Uses the SPLITT C++ library for parallel tree traversal described in Mitov and Stadler (2018) <doi:10.1111/2041-210X.13136>.

Bivariate additive categorical regression via penalized maximum likelihood. Under a multinomial framework, the method fits bivariate models where both responses are nominal, ordinal, or a mix of the two. Partial proportional odds models are supported, with flexible (non-)uniform association structures. Various logit types and parametrizations can be specified for both marginals and the association, including Daleâ s model. The association structure can be regularized using polynomial-type penalty terms. Additive effects are modeled using P-splines. Standard methods such as summary(), residuals(), and predict() are available.

POM-aSPU test evaluates an association between an ordinal response and multiple phenotypes, for details see Kim and Pan (2017) <DOI:10.1002/gepi.22033>.

Estimates corrected Procrustean correlation between matrices for removing overfitting effect. Coissac Eric and Gonindard-Melodelima Christelle (2019) <doi:10.1101/842070>.

Reconstruction of paleoclimate niches using phylogenetic comparative methods and projection reconstructed niches onto paleoclimate maps. The user can specify various models of trait evolution or estimate the best fit model, include fossils, use one or multiple phylogenies for inference, and make animations of shifting suitable habitat through time. This model was first used in Lawing and Polly (2011), and further implemented in Lawing et al (2016) and Rivera et al (2020). Lawing and Polly (2011) <doi:10.1371/journal.pone.0028554> "Pleistocene climate, phylogeny and climate envelope models: An integrative approach to better understand species response to climate change" Lawing et al (2016) <doi:10.1086/687202> "Including fossils in phylogenetic climate reconstructions: A deep time perspective on the climatic niche evolution and diversification of spiny lizards (Sceloporus)" Rivera et al (2020) <doi:10.1111/jbi.13915> "Reconstructing historical shifts in suitable habitat of Sceloporus lineages using phylogenetic niche modelling.".

The Predictive Power Score (PPS) is an asymmetric, data-type-agnostic score that can detect linear or non-linear relationships between two variables. The score ranges from 0 (no predictive power) to 1 (perfect predictive power). PPS can be useful for data exploration purposes, in the same way correlation analysis is. For more information on PPS, see <https://github.com/paulvanderlaken/ppsr>.

The goal of planets is to provide of very simple and accessible data containing basic information from all known planets.

This package provides classes and methods for modelling and simulation of periodically correlated (PC) and periodically integrated time series. Compute theoretical periodic autocovariances and related properties of PC autoregressive moving average models. Some original methods including Boshnakov & Iqelan (2009) <doi:10.1111/j.1467-9892.2009.00617.x>, Boshnakov (1996) <doi:10.1111/j.1467-9892.1996.tb00281.x>.

This package implements a novel predictive model, Partially Interpretable Estimators (PIE), which jointly trains an interpretable model and a black-box model to achieve high predictive performance as well as partial model. See the paper, Wang, Yang, Li, and Wang (2021) <doi:10.48550/arXiv.2105.02410>.

Phylogenetic comparative methods represent models of continuous trait data associated with the tips of a phylogenetic tree. Examples of such models are Gaussian continuous time branching stochastic processes such as Brownian motion (BM) and Ornstein-Uhlenbeck (OU) processes, which regard the data at the tips of the tree as an observed (final) state of a Markov process starting from an initial state at the root and evolving along the branches of the tree. The PCMBase R package provides a general framework for manipulating such models. This framework consists of an application programming interface for specifying data and model parameters, and efficient algorithms for simulating trait evolution under a model and calculating the likelihood of model parameters for an assumed model and trait data. The package implements a growing collection of models, which currently includes BM, OU, BM/OU with jumps, two-speed OU as well as mixed Gaussian models, in which different types of the above models can be associated with different branches of the tree. The PCMBase package is limited to trait-simulation and likelihood calculation of (mixed) Gaussian phylogenetic models. The PCMFit package provides functionality for inference of these models to tree and trait data. The package web-site <https://venelin.github.io/PCMBase/> provides access to the documentation and other resources.

This package provides a set of tools to extract bibliographic content from PubMed database using NCBI REST API <https://www.ncbi.nlm.nih.gov/home/develop/api/>.

This package implements partition-assisted clustering and multiple alignments of networks. It 1) utilizes partition-assisted clustering to find robust and accurate clusters and 2) discovers coherent relationships of clusters across multiple samples. It is particularly useful for analyzing single-cell data set. Please see Li et al. (2017) <doi:10.1371/journal.pcbi.1005875> for detail method description.

Using the R package reticulate', this package creates an interface to the pysd toolset. The package provides an R interface to a number of pysd functions, and can read files in Vensim mdl format, and xmile format. The resulting simulations are returned as a tibble', and from that the results can be processed using dplyr and ggplot2'. The package has been tested using python3'.

This package implements the Product of Independent beta Probabilities dose Escalation (PIPE) design for dual-agent Phase I trials as described in Mander AP, Sweeting MJ (2015) <DOI:10.1002/sim.6434>.

This package provides a network-based systems biology tool for flexible identification of phenotype-specific subpathways in the cancer gene expression data with multiple categories (such as multiple subtype or developmental stages of cancer). Subtype Set Enrichment Analysis (SubSEA) and Dynamic Changed Subpathway Analysis (DCSA) are developed to flexible identify subtype specific and dynamic changed subpathways respectively. The operation modes include extraction of subpathways from biological pathways, inference of subpathway activities in the context of gene expression data, identification of subtype specific subpathways with SubSEA, identification of dynamic changed subpathways associated with the cancer developmental stage with DCSA, and visualization of the activities of resulting subpathways by using box plots and heat maps. Its capabilities render the tool could find the specific abnormal subpathways in the cancer dataset with multi-phenotype samples.

This package performs partial verification bias (PVB) correction for binary diagnostic tests, where PVB arises from selective patient verification in diagnostic accuracy studies. Supports correction of important accuracy measures -- sensitivity, specificity, positive predictive values and negative predictive value -- under missing-at-random and missing-not-at-random missing data mechanisms. Available methods and references are "Begg and Greenes methods" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x> and deGroot et al. (2011) <doi:10.1016/j.annepidem.2010.10.004>; "Multiple imputation" in Harel & Zhou (2006) <doi:10.1002/sim.2494>, "EM-based logistic regression" in Kosinski & Barnhart (2003) <doi:10.1111/1541-0420.00019>; "Inverse probability weighting" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x>; "Inverse probability bootstrap sampling" in Nahorniak et al. (2015) <doi:10.1371/journal.pone.0131765> and Arifin & Yusof (2022) <doi:10.3390/diagnostics12112839>; "Scaled inverse probability resampling methods" in Arifin & Yusof (2025) <doi:10.1371/journal.pone.0321440>.

Because larger (> 50 MB) data files cannot easily be committed to git, a different approach is required to manage data associated with an analysis in a GitHub repository. This package provides a simple work-around by allowing larger (up to 2 GB) data files to piggyback on a repository as assets attached to individual GitHub releases. These files are not handled by git in any way, but instead are uploaded, downloaded, or edited directly by calls through the GitHub API. These data files can be versioned manually by creating different releases. This approach works equally well with public or private repositories. Data can be uploaded and downloaded programmatically from scripts. No authentication is required to download data from public repositories.

Piecewise constant hazard models for survival data. The package allows for right-censored, left-truncated, and interval-censored data.

In linear LS regression, calculate for a given design matrix the multiplier K of coefficient standard errors such that the confidence intervals [b - K*SE(b), b + K*SE(b)] have a guaranteed coverage probability for all coefficient estimates b in any submodels after performing arbitrary model selection.

Visualizes a matrix object plainly as heatmap. It provides S3 functions to plot simple matrices and loading matrices.

NOTE: PARAMLINK HAS BEEN SUPERSEDED BY THE PEDSUITE PACKAGES (<https://magnusdv.github.io/pedsuite/>). PARAMLINK IS MAINTAINED ONLY FOR LEGACY PURPOSES AND SHOULD NOT BE USED IN NEW PROJECTS. A suite of tools for analysing pedigrees with marker data, including parametric linkage analysis, forensic computations, relatedness analysis and marker simulations. The core of the package is an implementation of the Elston-Stewart algorithm for pedigree likelihoods, extended to allow mutations as well as complex inbreeding. Features for linkage analysis include singlepoint LOD scores, power analysis, and multipoint analysis (the latter through a wrapper to the MERLIN software). Forensic applications include exclusion probabilities, genotype distributions and conditional simulations. Data from the Familias software can be imported and analysed in paramlink'. Finally, paramlink offers many utility functions for creating, manipulating and plotting pedigrees with or without marker data (the actual plotting is done by the kinship2 package).

Clustering is unsupervised and exploratory in nature. Yet, it can be performed through penalized regression with grouping pursuit. In this package, we provide two algorithms for fitting the penalized regression-based clustering (PRclust) with non-convex grouping penalties, such as group truncated lasso, MCP and SCAD. One algorithm is based on quadratic penalty and difference convex method. Another algorithm is based on difference convex and ADMM, called DC-ADD, which is more efficient. Generalized cross validation and stability based method were provided to select the tuning parameters. Rand index, adjusted Rand index and Jaccard index were provided to estimate the agreement between estimated cluster memberships and the truth.