Fast functions for dealing with prime numbers, such as testing whether a number is prime and generating a sequence prime numbers. Additional functions include finding prime factors and Ruth-Aaron pairs, finding next and previous prime numbers in the series, finding or estimating the nth prime, estimating the number of primes less than or equal to an arbitrary number, computing primorials, prime k-tuples (e.g., twin primes), finding the greatest common divisor and smallest (least) common multiple, testing whether two numbers are coprime, and computing Euler's totient function. Most functions are vectorized for speed and convenience.

Computes the Patient-Reported Outcomes (PROs) Joint Contrast (PJC), a residual-based summary that captures information left over after accounting for the clinical Disease Activity index for Psoriatic Arthritis (cDAPSA). PROs (pain and patient global assessment) and joint counts (swollen and tender) are standardized, then each component is adjusted for standardized cDAPSA using natural spline coefficients that were derived from previously published models. The resulting residuals are standardized and combined using fixed principal component loadings, to yield a continuous PJC score and quartile groupings. This package provides a calculator for applying those published coefficients to new datasets; it does not itself estimate spline models or principal components.

This package provides a quadratic time dynamic programming algorithm can be used to compute an approximate solution to the problem of finding the most likely changepoints with respect to the Poisson likelihood, subject to a constraint on the number of segments, and the changes which must alternate: up, down, up, down, etc. For more info read <http://proceedings.mlr.press/v37/hocking15.html> "PeakSeg: constrained optimal segmentation and supervised penalty learning for peak detection in count data" by TD Hocking et al, proceedings of ICML2015.

This package provides a set of functions to efficiently recognize and clean the continuous dorsal pattern of a female brown anole lizard (Anolis sagrei) traced from ImageJ', an open platform for scientific image analysis (see <https://imagej.net> for more information), and extract common features such as the pattern sinuosity indices, coefficient of variation, and max-min width.

This package implements a partial linear semiparametric mixed-effects model (PLSMM) featuring a random intercept and applies a lasso penalty to both the fixed effects and the coefficients associated with the nonlinear function. The model also accommodates interactions between the nonlinear function and a grouping variable, allowing for the capture of group-specific nonlinearities. Nonlinear functions are modeled using a set of bases functions. Estimation is conducted using a penalized Expectation-Maximization algorithm, and the package offers flexibility in choosing between various information criteria for model selection. Post-selection inference is carried out using a debiasing method, while inference on the nonlinear functions employs a bootstrap approach.

Easy function for text-mining the PubMed repository based on defined sets of terms. The relationship between fix-terms (related to your research topic) and pub-terms (terms which pivot around your research focus) is calculated using the pointwise mutual information algorithm ('PMI'). Church, Kenneth Ward and Hanks, Patrick (1990) <https://www.aclweb.org/anthology/J90-1003/> A text file is generated with the PMI'-scores for each fix-term. Then for each collocation pairs (a fix-term + a pub-term), a text file is generated with related article titles and publishing years. Additional Author section will follow in the next version updates.

Returns almost all features that has been extracted from Position Specific Scoring Matrix (PSSM) so far, which is a matrix of L rows (L is protein length) and 20 columns produced by PSI-BLAST which is a program to produce PSSM Matrix from multiple sequence alignment of proteins see <https://www.ncbi.nlm.nih.gov/books/NBK2590/> for mor details. some of these features are described in Zahiri, J., et al.(2013) <DOI:10.1016/j.ygeno.2013.05.006>, Saini, H., et al.(2016) <DOI:10.17706/jsw.11.8.756-767>, Ding, S., et al.(2014) <DOI:10.1016/j.biochi.2013.09.013>, Cheng, C.W., et al.(2008) <DOI:10.1186/1471-2105-9-S12-S6>, Juan, E.Y., et al.(2009) <DOI:10.1109/CISIS.2009.194>.

Computes probabilities of the bivariate normal distribution in a vectorized R function (Drezner & Wesolowsky, 1990, <doi:10.1080/00949659008811236>).

Use the paged media properties in CSS and the JavaScript library paged.js to split the content of an HTML document into discrete pages. Each page can have its page size, page numbers, margin boxes, and running headers, etc. Applications of this package include books, letters, reports, papers, business cards, resumes, and posters.

High Dynamic Range (HDR) images support a large range in luminosity between the lightest and darkest regions of an image. To capture this range, data in HDR images is often stored as floating point numbers and in formats that capture more data and channels than standard image types. This package supports reading and writing two types of HDR images; PFM (Portable Float Map) and OpenEXR images. HDR images can be converted to lower dynamic ranges (for viewing) using tone-mapping. A number of tone-mapping algorithms are included which are based on Reinhard (2002) "Photographic tone reproduction for digital images" <doi:10.1145/566654.566575>.

We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).

Calculates the Probability Plot Correlation Coefficient (PPCC) between a continuous variable X and a specified distribution. The corresponding composite hypothesis test that was first introduced by Filliben (1975) <doi: 10.1080/00401706.1975.10489279> can be performed to test whether the sample X is element of either the Normal, log-Normal, Exponential, Uniform, Cauchy, Logistic, Generalized Logistic, Gumbel (GEVI), Weibull, Generalized Extreme Value, Pearson III (Gamma 2), Mielke's Kappa, Rayleigh or Generalized Logistic Distribution. The PPCC test is performed with a fast Monte-Carlo simulation.

Patient Rule Induction Method (PRIM) for bump hunting in high-dimensional data.

This package performs pathway enrichment analysis using a voting-based framework that integrates CpGâ gene regulatory information from expression quantitative trait methylation (eQTM) data. For a grid of top-ranked CpGs and filtering thresholds, gene sets are generated and refined using an entropy-based pruning strategy that balances information richness, stability, and probe bias correction. In particular, gene lists dominated by genes with disproportionately high numbers of CpG mappings are penalized to mitigate active probe biasâ a common artifact in methylation data analysis. Enrichment results across parameter combinations are then aggregated using a voting scheme, prioritizing pathways that are consistently recovered under diverse settings and robust to parameter perturbations.

This package provides a simple interface in the form of R6 classes for executing tasks in parallel, tracking their progress, and displaying accurate progress bars.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Maternal Mortality questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of Sustainable Development Goals (SDGs) monitoring, as the survey produces information on 32 global Sustainable Development Goals (SDGs) indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using probability proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

Piecewise constant hazard models for survival data. The package allows for right-censored, left-truncated, and interval-censored data.

This package provides a collection of software provides R support for ADMB (Automatic Differentiation Model Builder) and a GUI interface facilitates the conversion of ADMB template code to C code followed by compilation to a binary executable. Stand-alone functions can also be run by users not interested in clicking a GUI'.

Confidence intervals and point estimation for R under various parametric model assumptions; likelihood inference based on classical first-order approximations and higher-order asymptotic procedures.

This package implements an efficient and powerful Bayesian approach for sparse high-dimensional linear regression. It uses minimal prior assumptions on the parameters through plug-in empirical Bayes estimates of hyperparameters. An efficient Parameter-Expanded Expectation-Conditional-Maximization (PX-ECM) algorithm estimates maximum a posteriori (MAP) values of regression parameters and variable selection probabilities. The PX-ECM results in a robust computationally efficient coordinate-wise optimization, which adjusts for the impact of other predictor variables. The E-step is motivated by the popular two-group approach to multiple testing. The result is a PaRtitiOned empirical Bayes Ecm (PROBE) algorithm applied to sparse high-dimensional linear regression, implemented using one-at-a-time or all-at-once type optimization. More information can be found in McLain, Zgodic, and Bondell (2022) <arXiv:2209.08139>.

An implementation of the generalized power analysis for the local average treatment effect (LATE), proposed by Bansak (2020) <doi:10.1214/19-STS732>. Power analysis is in the context of estimating the LATE (also known as the complier average causal effect, or CACE), with calculations based on a test of the null hypothesis that the LATE equals 0 with a two-sided alternative. The method uses standardized effect sizes to place a conservative bound on the power under minimal assumptions. Package allows users to recover power, sample size requirements, or minimum detectable effect sizes. Package also allows users to work with absolute effects rather than effect sizes, to specify an additional assumption to narrow the bounds, and to incorporate covariate adjustment.

Design, backtest, and analyze portfolio strategies using simple, English-like function chains. Includes technical indicators, flexible stock selection, portfolio construction methods (equal weighting, signal weighting, inverse volatility, hierarchical risk parity), and a compact backtesting engine for portfolio returns, drawdowns, and summary metrics.

This package provides a bioinformatics method developed for analyzing the heterogeneity of single-cell populations. Phitest provides an objective and automatic method to evaluate the performance of clustering and quality of cell clusters.

Data and analysis from an experiment with improving touch typing speed, using the tDCS PlatoWork headset produced by PlatoScience.