Troubleshooting reactive data in shiny can be difficult. These functions will convert reactive data frames into functions and load all assigned objects into your local environment. If you create a dummy input object, as the function will suggest, you will be able to test your server and ui functions interactively.

This package provides a workflow based on scTenifoldNet to perform in-silico knockout experiments using single-cell RNA sequencing (scRNA-seq) data from wild-type (WT) control samples as input. First, the package constructs a single-cell gene regulatory network (scGRN) and knocks out a target gene from the adjacency matrix of the WT scGRN by setting the geneâ s outdegree edges to zero. Then, it compares the knocked out scGRN with the WT scGRN to identify differentially regulated genes, called virtual-knockout perturbed genes, which are used to assess the impact of the gene knockout and reveal the geneâ s function in the analyzed cells.

Allows to connect selectizeInputs widgets as filters to a reactable table. As known from spreadsheet applications, column filters are interdependent, so each filter only shows the values that are really available at the moment based on the current selection in other filters. Filter values currently not available (and also those being available) can be shown via popovers or tooltips.

This package provides access to granular sub-national income data from the MCC-PIK Database Of Sub-national Economic Output (DOSE). The package downloads and processes the data from its open repository on Zenodo (<https://zenodo.org/records/20035157>). Functions are provided to fetch data at multiple geographic levels, match coordinates to administrative regions, and access associated geometries.

Input widget that allows to construct complex filtering queries in Shiny'. It's a wrapper for JavaScript library jQuery-QueryBuilder', check <https://querybuilder.js.org/>.

The package performs a sensitivity analysis in an observational study using an M-statistic, for instance, the mean. The main function in the package is senmv(), but amplify() and truncatedP() are also useful. The method is developed in Rosenbaum Biometrics, 2007, 63, 456-464, <doi:10.1111/j.1541-0420.2006.00717.x>.

This package provides a framework for undertaking space and time varying coefficient models (varying parameter models) using a Generalized Additive Model (GAM) with smooths approach. The framework suggests the need to investigate for the presence and nature of any space-time dependencies in the data. It proposes a workflow that creates and refines an initial space-time GAM and includes tools to create and evaluate multiple model forms. The workflow sequence is to: i) Prepare the data by lengthening it to have a single location and time variables for each observation. ii) Create all possible space and/or time models in which each predictor is specified in different ways in smooths. iii) Evaluate each model via their AIC value and pick the best one. iv) Create the final model. v) Calculate the varying coefficient estimates to quantify how the relationships between the target and predictor variables vary over space, time or space-time. vi) Create maps, time series plots etc. The number of knots used in each smooth can be specified directly or iteratively increased. This is illustrated with a climate point dataset of the dry rain forest in South America. This builds on work in Comber et al (2024) <doi:10.1080/13658816.2023.2270285> and Comber et al (2004) <doi:10.3390/ijgi13120459>.

We designed this package to provide several functions for area level of small area estimation using hierarchical Bayesian (HB) method. This package provides model using panel data for variable interest.This package also provides a dataset produced by a data generation. The rjags package is employed to obtain parameter estimates. Model-based estimators involves the HB estimators which include the mean and the variation of mean. For the reference, see Rao and Molina (2015).

Simple Component Analysis (SCA) often provides much more interpretable components than Principal Components (PCA) while still representing much of the variability in the data.

This package provides basic functions that support an implementation of multi-profile case (Case 3) best-worst scaling (BWS). Case 3 BWS is a question-based survey method to elicit people's preferences for attribute levels. Case 3 BWS constructs various combinations of attribute levels (profiles) and then asks respondents to select the best and worst profiles in each choice set. A main function creates a dataset for the analysis from the choice sets and the responses to the questions. For details on Case 3 BWS, refer to Louviere et al. (2015) <doi:10.1017/CBO9781107337855>.

The President of the United States is constitutionally obligated to provide a report known as the State of the Union'. The report summarizes the current challenges facing the country and the president's upcoming legislative agenda. While historically the State of the Union was often a written document, in recent decades it has always taken the form of an oral address to a joint session of the United States Congress. This package provides the raw text from every such address with the intention of being used for meaningful examples of text analysis in R. The corpus is well suited to the task as it is historically important, includes material intended to be read and material intended to be spoken, and it falls in the public domain. As the corpus spans over two centuries it is also a good test of how well various methods hold up to the idiosyncrasies of historical texts. Associated data about each address, such as the year, president, party, and format, are also included.

This package provides functions that wrap HTML Bootstrap components code to enable the design and layout of informative landing home pages for Shiny applications. This can lead to a better user experience for the users and writing less HTML for the developer.

This package provides developer-focused helper functions and S3 classes to ease the creation of structured subtypes of data frames. Developers can require certain columns and types to be present, and can enforce crossing and nesting relationships between values in different columns. Type-specific metadata and attributes are preserved through common data frame manipulations.

This package implements a segmentation algorithm for multiple change-point detection in high-dimensional GARCH processes. It simultaneously segments GARCH processes by identifying common change-points, each of which can be shared by a subset or all of the component time series as a change-point in their within-series and/or cross-sectional correlation structure.

Access Amazon Web Service Simple Storage Service ('S3') <https://aws.amazon.com/s3/> as if it were a file system. Interface based on the R package fs'.

Animal movement models including Moving-Resting Process with Embedded Brownian Motion (Yan et al., 2014, <doi:10.1007/s10144-013-0428-8>; Pozdnyakov et al., 2017, <doi:10.1007/s11009-017-9547-6>), Brownian Motion with Measurement Error (Pozdnyakov et al., 2014, <doi:10.1890/13-0532.1>), Moving-Resting-Handling Process with Embedded Brownian Motion (Pozdnyakov et al., 2020, <doi:10.1007/s11009-020-09774-1>), Moving-Resting Process with Measurement Error (Hu et al., 2021, <doi:10.1111/2041-210X.13694>), Moving-Moving Process with two Embedded Brownian Motions.

Create Upset plots using a combination of ggplot2 and patchwork'.

Assigns a score projection from 0 to 1 between a given in vivo stage and each single cluster from an in vitro dataset. The score is assigned based on the the fraction of specific markers of the in vivo stage that are conserved in the in vitro clusters <https://github.com/ScialdoneLab>.

Spectra viewer, organizer, data preparation and property blocks from within R or stand-alone. Binary (application) part is installed separately using spnInstallApp() from spectrino package.

Spatial components offer tools for dimension reduction and spatially variable gene detection for high dimensional spatial transcriptomics data. Construction of a projection onto low-dimensional feature space of spatially dependent metagenes offers pre-processing to clustering, testing for spatial variability and denoising of spatial expression patterns. For more details, see Koehler et al. (2026) <doi:10.1093/bioinformatics/btag052>.

Convert a time series of observations to a time series of standardised indices that can be used to monitor variables on a common and probabilistically interpretable scale. The indices can be aggregated and rescaled to different time scales, visualised using plot capabilities, and calculated using a range of distributions. This includes flexible non-parametric and non-stationary methods.

Single cell resolution data has been valuable in learning about tissue microenvironments and interactions between cells or spots. This package allows for the simulation of this level of data, be it single cell or â spotsâ , in both a univariate (single metric or cell type) and bivariate (2 or more metrics or cell types) ways. As more technologies come to marker, more methods will be developed to derive spatial metrics from the data which will require a way to benchmark methods against each other. Additionally, as the field currently stands, there is not a gold standard method to be compared against. We set out to develop an R package that will allow users to simulate point patterns that can be biologically informed from different tissue domains, holes, and varying degrees of clustering/colocalization. The data can be exported as spatial files and a summary file (like HALO'). <https://github.com/FridleyLab/scSpatialSIM/>.

Explains the behavior of a time series by decomposing it into its trend, seasonality and residuals. It is built to perform very well in the presence of significant level shifts. It is designed to play well with any breakpoint algorithm and any smoothing algorithm. Currently defaults to lowess for smoothing and strucchange for breakpoint identification. The package is useful in areas such as trend analysis, time series decomposition, breakpoint identification and anomaly detection.

It implements parametric formulas of soil water retention or conductivity curve. At the moment, only Van Genuchten (for soil water retention curve) and Mualem (for hydraulic conductivity) were implemented. See reference (<http://en.wikipedia.org/wiki/Water_retention_curve>).