Develop Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. The Pharmacometric Modeling Language (PML) code updates in real time given changes to user inputs. Models can be executed using the Certara.RsNLME package. Additional support to generate the underlying Certara.RsNLME code to recreate the corresponding model in R is provided in the user interface.

Many correlation coefficient related functions are offered, such as correlations, partial correlations and hypothesis testing using asymptotic tests and computer intensive methods (bootstrap and permutation). References include Mardia K.V., Kent J.T. and Bibby J.M. (1979). "Multivariate Analysis". ISBN: 978-0124712522. London: Academic Press and Owen A. B. (2001). "Empirical likelihood". Chapman and Hall/CRC Press. ISBN: 9781584880714.

Includes wrapper functions around existing functions for the analysis of categorical data and introduces functions for calculating risk differences and matched odds ratios. R currently supports a wide variety of tools for the analysis of categorical data. However, many functions are spread across a variety of packages with differing syntax and poor compatibility with each another. prop_test() combines the functions binom.test(), prop.test() and BinomCI() into one output. prop_power() allows for power and sample size calculations for both balanced and unbalanced designs. riskdiff() is used for calculating risk differences and matched_or() is used for calculating matched odds ratios. For further information on methods used that are not documented in other packages see Nathan Mantel and William Haenszel (1959) <doi:10.1093/jnci/22.4.719> and Alan Agresti (2002) <ISBN:0-471-36093-7>.

This package provides functions for fitting GEV and POT (via point process fitting) models for extremes in climate data, providing return values, return probabilities, and return periods for stationary and nonstationary models. Also provides differences in return values and differences in log return probabilities for contrasts of covariate values. Functions for estimating risk ratios for event attribution analyses, including uncertainty. Under the hood, many of the functions use functions from extRemes', including for fitting the statistical models. Details are given in Paciorek, Stone, and Wehner (2018) <doi:10.1016/j.wace.2018.01.002>.

Cristin to Zotero ('c2z') aims at obtaining total dominion over Cristin ('Current Research Information SysTem in Norway') and Zotero'. The package enables manipulating Zotero libraries using R'. Import references from Cristin', Regjeringen', CRAN', ISBN ('Alma', LoC'), and DOI ('CrossRef', DataCite') to a Zotero library. Add, edit, copy, or delete items, including attachments and collections, and export references to BibLaTeX (and other formats).

This package provides a helpful R6 class and methods for interacting with the Posit Connect Server API along with some meaningful utility functions for regular tasks. API documentation varies by Posit Connect installation and version, but the latest documentation is also hosted publicly at <https://docs.posit.co/connect/api/>.

Create descriptive tables for continuous and categorical variables. Apply summary statistics and counting function, with or without a grouping variable, and create beautiful reports using rmarkdown or officer'. You can also compute effect sizes and statistical tests if needed.

Implementations of canonical associative learning models, with tools to run experiment simulations, estimate model parameters, and compare model representations. Experiments and results are represented using S4 classes and methods.

Curates biological sequences massively, quickly, without errors and without internet connection. Biological sequences curing is performed by aligning the forward and / or revers primers or ends of cloning vectors with the sequences to be cleaned. After the alignment, new subsequences are generated without biological fragment not desired by the user. Pozzi et al (2020) <doi:10.1007/s00438-020-01671-z>.

Interface to the Google Cloud Machine Learning Platform <https://cloud.google.com/vertex-ai>, which provides cloud tools for training machine learning models.

Customized training is a simple technique for transductive learning, when the test covariates are known at the time of training. The method identifies a subset of the training set to serve as the training set for each of a few identified subsets in the training set. This package implements customized training for the glmnet() and cv.glmnet() functions.

Datasets relating to population in municipalities, municipality/county matching, and how different municipalities have merged/redistricted over time from 2006 to 2024.

Composite likelihood parameter estimate and asymptotic covariance matrix are calculated for the spatial ordinal data with replications, where spatial ordinal response with covariate and both spatial exponential covariance within subject and independent and identically distributed measurement error. Parameter estimation can be performed by either solving the gradient function or maximizing composite log-likelihood. Parametric bootstrapping is used to estimate the Godambe information matrix and hence the asymptotic standard error and covariance matrix with parallel processing option. Moreover, the proposed surrogate residual, which extends the results of Liu and Zhang (2017) <doi: 10.1080/01621459.2017.1292915>, can act as a useful tool for model diagnostics.

Estimation of crop water demand can be processed via this package. As example, the data from TerraClimate dataset (<https://www.climatologylab.org/terraclimate.html>) calibrated with automatic weather stations of National Meteorological Institute of Brazil is available in a coarse spatial resolution to do the crop water demand. However, the user have also the option to download the variables directly from TerraClimate repository with the download.terraclimate function and access the original TerraClimate products. If the user believes that is necessary calibrate the variables, there is another function to do it. Lastly, the estimation of the crop water demand present in this package can be run for all the Brazilian territory with TerraClimate dataset.

It provides functions to bootstrap Credit Curves from market quotes (Credit Default Swap - CDS - spreads) and price Credit Default Swaps - CDS.

Create contour lines for a non regular series of points, potentially from a non-regular canvas.

Helpful functions for the cleaning and manipulation of surveillance data, especially with regards to the creation and validation of panel data from individual level surveillance data.

Several functions are available for calculating the most widely used effect sizes (ES), along with their variances, confidence intervals and p-values. The output includes ES's of d (mean difference), g (unbiased estimate of d), r (correlation coefficient), z (Fisher's z), and OR (odds ratio and log odds ratio). In addition, NNT (number needed to treat), U3, CLES (Common Language Effect Size) and Cliff's Delta are computed. This package uses recommended formulas as described in The Handbook of Research Synthesis and Meta-Analysis (Cooper, Hedges, & Valentine, 2009). A free web application is available at <https://acdelre.github.io/apps/compute_es/>.

This package provides a feasible framework for mutation analysis and reverse transcription polymerase chain reaction (RT-PCR) assay evaluation of COVID-19, including mutation profile visualization, statistics and mutation ratio of each assay. The mutation ratio is conducive to evaluating the coverage of RT-PCR assays in large-sized samples. Mercatelli, D. and Giorgi, F. M. (2020) <doi:10.20944/preprints202004.0529.v1>.

Explore calcium (Ca) and phosphate (Pi) homeostasis with two novel Shiny apps, building upon on a previously published mathematical model written in C, to ensure efficient computations. The underlying model is accessible here <https://pubmed.ncbi.nlm.nih.gov/28747359/)>. The first application explores the fundamentals of Ca-Pi homeostasis, while the second provides interactive case studies for in-depth exploration of the topic, thereby seeking to foster student engagement and an integrative understanding of Ca-Pi regulation.

Easily automate the following tasks to describe data frames: Summarise the distributions, and labelled missings of variables graphically and using descriptive statistics. For surveys, compute and summarise reliabilities (internal consistencies, retest, multilevel) for psychological scales. Combine this information with metadata (such as item labels and labelled values) that is derived from R attributes. To do so, the package relies on rmarkdown partials, so you can generate HTML, PDF, and Word documents. Codebooks are also available as tables (CSV, Excel, etc.) and in JSON-LD, so that search engines can find your data and index the metadata. The metadata are also available at your fingertips via RStudio Addins.

Random sampling from distributions with user-specified population covariance matrix. Marginal information may be fully specified, for which the package implements the VITA (VIne-To-Anything) algorithm Grønneberg and Foldnes (2017) <doi:10.1007/s11336-017-9569-6>. See also Grønneberg, Foldnes and Marcoulides (2022) <doi:10.18637/jss.v102.i03>. Alternatively, marginal skewness and kurtosis may be specified, for which the package implements the IG (independent generator) and PLSIM (piecewise linear) algorithms, see Foldnes and Olsson (2016) <doi:10.1080/00273171.2015.1133274> and Foldnes and Grønneberg (2021) <doi:10.1080/10705511.2021.1949323>, respectively.

This package provides API access to the Government of Canada Vehicle Recalls Database <https://tc.api.canada.ca/en/detail?api=VRDB> used by the Defect Investigations and Recalls Division for vehicles, tires, and child car seats. The API wrapper provides access to recall summary information searched using make, model, and year range, as well as detailed recall information searched using recall number.

Tests on properties of space-time covariance functions. Tests on symmetry, separability and for assessing different forms of non-separability are available. Moreover tests on some classes of covariance functions, such that the classes of product-sum models, Gneiting models and integrated product models have been provided. It is the companion R package to the papers of Cappello, C., De Iaco, S., Posa, D., 2018, Testing the type of non-separability and some classes of space-time covariance function models <doi:10.1007/s00477-017-1472-2> and Cappello, C., De Iaco, S., Posa, D., 2020, covatest: an R package for selecting a class of space-time covariance functions <doi:10.18637/jss.v094.i01>.