This package provides a generic, easy-to-use and expandable implementation of a pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4 class system. This package allows the user to read and write pharmacometric models from and to files, including a JSON-based interface to import Campsis models defined using a formal JSON schema distributed with the package. Models can be adapted further on the fly in the R environment using an intuitive API to add, modify or delete equations, ordinary differential equations (ODEs), model parameters or compartment properties (such as infusion duration or rate, bioavailability and initial values). The package also provides export facilities for use with the simulation packages â rxode2â and â mrgsolveâ . The package itself is licensed under the GPL (>= 3); the JSON schema file shipped in inst/extdata is licensed separately under the Creative Commons Attribution 4.0 International (CC BY 4.0). This package is designed and intended to be used with the package â campsisâ , a PK/PD simulation platform built on top of â rxode2â and â mrgsolveâ .

Easy way to draw chronological charts from tables, aiming to include an intuitive environment for anyone new to R. Includes ggplot2 geoms and theme for chronological charts.

Generate cohorts and subsets using an Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) Database. Cohorts are defined using CIRCE (<https://github.com/ohdsi/circe-be>) or SQL compatible with SqlRender (<https://github.com/OHDSI/SqlRender>).

Quite extensive package for maximum likelihood estimation and weighted least squares estimation of categorical marginal models (CMMs; e.g., Bergsma and Rudas, 2002, <http://www.jstor.org/stable/2700006?; Bergsma, Croon and Hagenaars, 2009, <DOI:10.1007/b12532>.

Estimates latent class vector-autoregressive models via EM algorithm on time-series data for model-based clustering and classification. Includes model selection criteria for selecting the number of lags and clusters.

Column Text Format (CTF) is a new tabular data format designed for simplicity and performance. CTF is the simplest column store you can imagine: plain text files for each column in a table, and a metadata file. The underlying plain text means the data is human readable and familiar to programmers, unlike specialized binary formats. CTF is faster than row oriented formats like CSV when loading a subset of the columns in a table. This package provides functions to read and write CTF data from R.

The goal of cvsem is to provide functions that allow for comparing Structural Equation Models (SEM) using cross-validation. Users can specify multiple SEMs using lavaan syntax. cvsem computes the Kullback Leibler (KL) Divergence between 1) the model implied covariance matrix estimated from the training data and 2) the sample covariance matrix estimated from the test data described in Cudeck, Robert & Browne (1983) <doi:10.18637/jss.v048.i02>. The KL Divergence is computed for each of the specified SEMs allowing for the models to be compared based on their prediction errors.

This package creates ggplot2 Cumulative Residual (CURE) plots to check the goodness-of-fit of a count model; or the tables to create a customized version. A dataset of crashes in Washington state is available for illustrative purposes.

This package provides a collection of common test and item analyses from a classical test theory (CTT) framework. Analyses can be applied to both dichotomous and polytomous data. Functions provide reliability analyses (alpha), item statistics, disctractor analyses, disattenuated correlations, scoring routines, and empirical ICCs.

Implementation of the Wilkinson and Ivany (2002) approach to paleoclimate analysis, applied to isotope data extracted from clams.

This package provides a fast and general implementation of the Elston-Stewart algorithm that can calculate the likelihoods of large and complex pedigrees. References for the Elston-Stewart algorithm are Elston & Stewart (1971) <doi:10.1159/000152448>, Lange & Elston (1975) <doi:10.1159/000152714> and Cannings et al. (1978) <doi:10.2307/1426718>.

Set of functions to import COVID-19 pandemic data into R. The Brazilian COVID-19 data, obtained from the official Brazilian repository at <https://covid.saude.gov.br/>, is available at the country, region, state, and city levels. The package also downloads world-level COVID-19 data from Johns Hopkins University's repository. COVID-19 data is available from the start of follow-up until to May 5, 2023, when the World Health Organization (WHO) declared an end to the Public Health Emergency of International Concern (PHEIC) for COVID-19.

Cointegration methods are widely used in empirical macroeconomics and empirical finance. It is well known that in a cointegrating regression the ordinary least squares (OLS) estimator of the parameters is super-consistent, i.e. converges at rate equal to the sample size T. When the regressors are endogenous, the limiting distribution of the OLS estimator is contaminated by so-called second order bias terms, see e.g. Phillips and Hansen (1990) <DOI:10.2307/2297545>. The presence of these bias terms renders inference difficult. Consequently, several modifications to OLS that lead to zero mean Gaussian mixture limiting distributions have been proposed, which in turn make standard asymptotic inference feasible. These methods include the fully modified OLS (FM-OLS) approach of Phillips and Hansen (1990) <DOI:10.2307/2297545>, the dynamic OLS (D-OLS) approach of Phillips and Loretan (1991) <DOI:10.2307/2298004>, Saikkonen (1991) <DOI:10.1017/S0266466600004217> and Stock and Watson (1993) <DOI:10.2307/2951763> and the new estimation approach called integrated modified OLS (IM-OLS) of Vogelsang and Wagner (2014) <DOI:10.1016/j.jeconom.2013.10.015>. The latter is based on an augmented partial sum (integration) transformation of the regression model. IM-OLS is similar in spirit to the FM- and D-OLS approaches, with the key difference that it does not require estimation of long run variance matrices and avoids the need to choose tuning parameters (kernels, bandwidths, lags). However, inference does require that a long run variance be scaled out. This package provides functions for the parameter estimation and inference with all three modified OLS approaches. That includes the automatic bandwidth selection approaches of Andrews (1991) <DOI:10.2307/2938229> and of Newey and West (1994) <DOI:10.2307/2297912> as well as the calculation of the long run variance.

Get description of images from Clarifai API. For more information, see <http://clarifai.com>. Clarifai uses a large deep learning cloud to come up with descriptive labels of the things in an image. It also provides how confident it is about each of the labels.

Fit a CoxSEI (Cox type Self-Exciting Intensity) model to right-censored counting process data.

Fits a Causal Effect Random Forest of Interaction Tress (CERFIT) which is a modification of the Random Forest algorithm where each split is chosen to maximize subgroup treatment heterogeneity. Doing this allows it to estimate the individualized treatment effect for each observation in either randomized controlled trial (RCT) or observational data. For more information see L. Li, R. A. Levine, and J. Fan (2022) <doi:10.1002/sta4.457>.

This package provides a wrapper for the U.S. Census Bureau APIs that returns data frames of Census data and metadata. Available datasets include the Decennial Census, American Community Survey, Small Area Health Insurance Estimates, Small Area Income and Poverty Estimates, Population Estimates and Projections, and more.

Core functions for simulating quantities of interest from generalised linear models (GLM). This package will form the backbone of a series of other packages that improve the interpretation of GLM estimates.

Access public spatial data available under the INSPIRE directive. Tools for downloading references and addresses of properties, as well as map images.

Calculates pointwise confidence intervals for the cumulative distribution function of the event time for current status data, data where each individual is assessed at one time to see if they had the event or not by the assessment time.

This package provides a compilation of tests for hypotheses regarding covariance and correlation matrices for one or more groups. The hypothesis can be specified through a corresponding hypothesis matrix and a vector or by choosing one of the basic hypotheses, while for the structure test, only the latter works. Thereby Monte-Carlo and Bootstrap-techniques are used, and the respective method must be chosen, and the functions provide p-values and mostly also estimators of calculated covariance matrices of test statistics. For more details on the methodology, see Sattler et al. (2022) <doi:10.1016/j.jspi.2021.12.001>, Sattler and Pauly (2024) <doi:10.1007/s11749-023-00906-6>, and Sattler and Dobler (2025) <doi:10.48550/arXiv.2310.11799>.

Implementation of Hurst exponent estimators based on complex-valued lifting wavelet energy from Knight, M. I and Nunes, M. A. (2018) <doi:10.1007/s11222-018-9820-8>.

Fast C++'-backed tools for computing conspecific and total neighborhood basal area in mapped forest plots. Includes unweighted and distance-weighted neighborhoods, multiple radii, decay kernels, and basic edge correction. Outputs are model-ready covariates for forest competition, growth, and survival models, following neighborhood modeling workflows commonly used in spatial ecology (e.g., Hülsmann et al. 2024 <doi:10.1038/s41586-024-07118-4>).

This package provides tools for the fitting and cross validation of exact conditional logistic regression models with lasso and elastic net penalties. Uses cyclic coordinate descent and warm starts to compute the entire path efficiently.