Filtering, also known as gating, of flow cytometry samples using the curvHDR method, which is described in Naumann, U., Luta, G. and Wand, M.P. (2010) <DOI:10.1186/1471-2105-11-44>.

An implementation of Fan plots for cytometry data in ggplot2'. For reference see Britton, E.; Fisher, P. & J. Whitley (1998) The Inflation Report Projections: Understanding the Fan Chart <https://www.bankofengland.co.uk/quarterly-bulletin/1998/q1/the-inflation-report-projections-understanding-the-fan-chart>).

This package provides simplified access to the data from the Catalog of Theses and Dissertations of the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES, <https://catalogodeteses.capes.gov.br>) for the years 1987 through 2022. The dataset includes variables such as Higher Education Institution (institution), Area of Concentration (area), Graduate Program Name (program_name), Type of Work (type), Language of Work (language), Author Identification (author), Abstract (abstract), Advisor Identification (advisor), Development Region (region), State (state).

This package implements the conditionally symmetric multidimensional Gaussian mixture model (csmGmm) for large-scale testing of composite null hypotheses in genetic association applications such as mediation analysis, pleiotropy analysis, and replication analysis. In such analyses, we typically have J sets of K test statistics where K is a small number (e.g. 2 or 3) and J is large (e.g. 1 million). For each one of the J sets, we want to know if we can reject all K individual nulls. Please see the vignette for a quickstart guide. The paper describing these methods is "Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies" by Sun R, McCaw Z, & Lin X (Journal of the American Statistical Association 2025, <doi:10.1080/01621459.2024.2422124>).

Extracts colors from various image types, returns customized reports and plots treemaps and 3D scatterplots of image compositions. Color palettes can also be created.

This package provides a toolkit for making use of credentials mediated by Posit Connect'. It handles the details of communicating with the Connect API correctly, OAuth token caching, and refresh behaviour.

Includes wrapper functions around existing functions for the analysis of categorical data and introduces functions for calculating risk differences and matched odds ratios. R currently supports a wide variety of tools for the analysis of categorical data. However, many functions are spread across a variety of packages with differing syntax and poor compatibility with each another. prop_test() combines the functions binom.test(), prop.test() and BinomCI() into one output. prop_power() allows for power and sample size calculations for both balanced and unbalanced designs. riskdiff() is used for calculating risk differences and matched_or() is used for calculating matched odds ratios. For further information on methods used that are not documented in other packages see Nathan Mantel and William Haenszel (1959) <doi:10.1093/jnci/22.4.719> and Alan Agresti (2002) <ISBN:0-471-36093-7>.

Several authors have proposed methods for constructing simultaneous confidence intervals for multinomial proportions. The package implements seven classical approachesâ Wilson, Quesenberry and Hurst, Goodman, Wald (with and without continuity correction), Fitzpatrick and Scott, and Sison and Glazâ along with Bayesian methods based on Dirichlet models. Both equal and unequal Dirichlet priors are supported, providing a broad framework for inference, data analysis, and sensitivity evaluation.

This package implements the count splitting methodology from Neufeld et al. (2022) <doi:10.1093/biostatistics/kxac047> and Neufeld et al. (2023) <arXiv:2307.12985>. Intended for turning a matrix of single-cell RNA sequencing counts, or similar count datasets, into independent folds that can be used for training/testing or cross validation. Assumes that the entries in the matrix are from a Poisson or a negative binomial distribution.

This package provides a generic, easy-to-use and intuitive pharmacokinetic/pharmacodynamic (PK/PD) simulation platform based on the R packages rxode2 and mrgsolve'. Campsis provides an abstraction layer over the underlying processes of defining a PK/PD model, assembling a custom dataset and running a simulation. The package has a strong dependency on the R package campsismod', which allows models to be read from and written to files, including through a JSON-based interface, and to be adapted further on the fly in the R environment. In addition, campsis allows users to assemble datasets in an intuitive manner, including via a JSON-based interface to import Campsis datasets defined using formal JSON schemas distributed with the package. Once the dataset is ready, the package prepares the simulation, calls rxode2 or mrgsolve (at the user's choice), and returns the results for the given model, dataset and desired simulation settings. The package itself is licensed under the GPL (>= 3); the JSON schema files shipped in inst/extdata are licensed separately under the Creative Commons Attribution 4.0 International (CC BY 4.0).

This package performs analysis of complex dynamic systems with a focus on the temporal unfolding of patterns, changes, and state transitions in behavioral data. Supports both time series and sequence data and provides tools for the analysis and visualization of complexity, pattern identification, trends, regimes, sequence typology as well as early warning signals.

Detects multiple changes in slope using the CPOP dynamic programming approach of Fearnhead, Maidstone, and Letchford (2019) <doi:10.1080/10618600.2018.1512868>. This method finds the best continuous piecewise linear fit to data under a criterion that measures fit to data using the residual sum of squares, but penalizes complexity based on an L0 penalty on changes in slope. Further information regarding the use of this package with detailed examples can be found in Fearnhead and Grose (2024) <doi:10.18637/jss.v109.i07>.

Encode and decode c-squares, from and to simple feature (sf) or spatiotemporal arrays (stars) objects. Use c-squares codes to quickly join or query spatial data.

Collection of utility functions for visualizing body map data collected with the Collaborative Health Outcomes Information Registry.

Covariate-augumented generalized factor model is designed to account for cross-modal heterogeneity, capture nonlinear dependencies among the data, incorporate additional information, and provide excellent interpretability while maintaining high computational efficiency.

Compare double-precision floating point vectors using relative differences. All equality operations are calculated using cpp11'.

Includes functions for the analysis of circular data using distributions based on Nonnegative Trigonometric Sums (NNTS). The package includes functions for calculation of densities and distributions, for the estimation of parameters, for plotting and more.

Estimate the severity of a disease and ascertainment of cases, as discussed in Nishiura et al. (2009) <doi:10.1371/journal.pone.0006852>.

Two-step feature-based clustering method designed for micro panel (longitudinal) data with the artificial panel data generator. See Sobisek, Stachova, Fojtik (2018) <arXiv:1807.05926>.

As different antipsychotic medications have different potencies, the doses of different medications cannot be directly compared. Various strategies are used to convert doses into a common reference so that comparison is meaningful. Chlorpromazine (CPZ) has historically been used as a reference medication into which other antipsychotic doses can be converted, as "chlorpromazine-equivalent doses". Using conversion keys generated from widely-cited scientific papers, e.g. Gardner et. al 2010 <doi:10.1176/appi.ajp.2009.09060802> and Leucht et al. 2016 <doi:10.1093/schbul/sbv167>, antipsychotic doses are converted to CPZ (or any specified antipsychotic) equivalents. The use of the package is described in the included vignette. Not for clinical use.

This package implements algorithms for analyzing Cayley graphs of permutation groups, with a focus on the TopSpin puzzle and similar permutation-based combinatorial puzzles. Provides methods for cycle detection, state space exploration, bidirectional BFS pathfinding, and finding optimal operation sequences in permutation groups generated by shift and reverse operations. Includes C++ implementations of core operations via Rcpp for performance. Optional GPU acceleration via ggmlR Vulkan backend for batch distance calculations and parallel state transformations.

The Central Bank of the Republic of Turkey (CBRT) provides one of the most comprehensive time series databases on the Turkish economy. The CBRT package provides functions for accessing the CBRT's electronic data delivery system <https://evds3.tcmb.gov.tr/>. It contains the lists of all data categories and data groups for searching the available variables (data series). As of February 17, 2026, there were 47,986 variables in the dataset. The lists of data categories and data groups can be updated by the user at any time. A specific variable, a group of variables, or all variables in a data group can be downloaded at different frequencies using a variety of aggregation methods.

Set of generalised tools for the flexible computation of climate related indicators defined by the user. Each method represents a specific mathematical approach which is combined with the possibility to select an arbitrary time period to define the indicator. This enables a wide range of possibilities to tailor the most suitable indicator for each particular climate service application (agriculture, food security, energy, water management, health...). This package is intended for sub-seasonal, seasonal and decadal climate predictions, but its methods are also applicable to other time-scales, provided the dimensional structure of the input is maintained. Additionally, the outputs of the functions in this package are compatible with CSTools'. This package is described in Pérez-Zanón et al. (2023) <doi:10.1016/j.cliser.2023.100393> and was developed in the context of the H2020 projects MED-GOLD (776467) and S2S4E (776787) projects, as well as the Horizon Europe project MEDEWSA (101121192) and the national project BOREAS (PID2022-140673OA-I00). See Lledó et al. (2019) <doi:10.1016/j.renene.2019.04.135> and Chou et al., 2023 <doi:10.1016/j.cliser.2023.100345> for details.

This package provides a set of utility tools to inspect spatial objects, facilitate handling and reporting of topology errors and geometry validity issue with sp objects. Finally, it provides a geometry cleaner that will fix all geometry problems, and eliminate (at least reduce) the likelihood of having issues when doing spatial data processing.