Simulate and implement early phase two-stage adaptive dose-finding design for binary and quasi-continuous toxicity endpoints. See Chiuzan et al. (2018) for further reading <DOI:10.1080/19466315.2018.1462727>.

Extensive penalized variable selection methods have been developed in the past two decades for analyzing high dimensional omics data, such as gene expressions, single nucleotide polymorphisms (SNPs), copy number variations (CNVs) and others. However, lipidomics data have been rarely investigated by using high dimensional variable selection methods. This package incorporates our recently developed penalization procedures to conduct interaction analysis for high dimensional lipidomics data with repeated measurements. The core module of this package is developed in C++. The development of this software package and the associated statistical methods have been partially supported by an Innovative Research Award from Johnson Cancer Research Center, Kansas State University.

Imputing blockwise missing data by imprecise imputation, featuring a domain-based, variable-wise, and case-wise strategy. Furthermore, the estimation of lower and upper bounds for unconditional and conditional probabilities based on the obtained imprecise data is implemented. Additionally, two utility functions are supplied: one to check whether variables in a data set contain set-valued observations; and another to merge two already imprecisely imputed data. The method is described in a technical report by Endres, Fink and Augustin (2018, <doi:10.5282/ubm/epub.42423>).

Calculates various intraclass correlation coefficients used to quantify inter-rater and intra-rater reliability. The assumption here is that the raters produced quantitative ratings. Most of the statistical procedures implemented in this package are described in details in Gwet, K.L. (2014, ISBN:978-0970806284): "Handbook of Inter-Rater Reliability," 4th edition, Advanced Analytics, LLC.

Fit parametric models for time-to-event data that show an initial incubation period', i.e., a variable delay phase where the hazard is zero. The delayed Weibull distribution serves as foundational data model. The specific method of MPSE (maximum product of spacings estimation) and MLE-based methods are used for parameter estimation. Bootstrap confidence intervals for parameters and significance tests in a two group setting are provided.

This package provides a dataframe validation framework for package builders who use dataframes as function parameters. It performs checks on column names, coerces data-types, and checks grouping to make sure user inputs conform to a specification provided by the package author. It provides a mechanism for package authors to automatically document supported dataframe inputs and selectively dispatch to functions depending on the format of a dataframe much like S3 does for classes. It also contains some developer tools to make working with and documenting dataframe specifications easier. It helps package developers to improve their documentation and simplifies parameter validation where dataframes are used as function parameters.

Item response theory (IRT) parameter estimation using marginal maximum likelihood and expectation-maximization algorithm (Bock & Aitkin, 1981 <doi:10.1007/BF02293801>). Within parameter estimation algorithm, several methods for latent distribution estimation are available. Reflecting some features of the true latent distribution, these latent distribution estimation methods can possibly enhance the estimation accuracy and free the normality assumption on the latent distribution.

An implementation to reconstruct individual patient data from Kaplan-Meier (K-M) survival curves, visualize and assess the accuracy of the reconstruction, then perform secondary analysis on the reconstructed data. We involve a simple function to extract the coordinates form the published K-M curves. The function is developed based on Poisot T. â s digitize package (2011) <doi:10.32614/RJ-2011-004> . For more complex and tangled together graphs, digitizing software, such as DigitizeIt (for MAC or windows) or ScanIt'(for windows) can be used to get the coordinates. Additional information should also be involved to increase the accuracy, like numbers of patients at risk (often reported at 5-10 time points under the x-axis of the K-M graph), total number of patients, and total number of events. The package implements the modified iterative K-M estimation algorithm (modified-iKM) improved upon the approach proposed by Guyot (2012) <doi:10.1186/1471-2288-12-9> with some modifications.

This package produces a publication-ready table that includes all effect estimates necessary for full reporting effect modification and interaction analysis as recommended by Knol and Vanderweele (2012) [<doi:10.1093/ije/dyr218>]. It also estimates confidence interval for the trio of additive interaction measures using the delta method (see Hosmer and Lemeshow (1992), [<doi:10.1097/00001648-199209000-00012>]), variance recovery method (see Zou (2008), [<doi:10.1093/aje/kwn104>]), or percentile bootstrapping (see Assmann et al. (1996), [<doi:10.1097/00001648-199605000-00012>]).

Computes characteristics of independent rainfall events (duration, total rainfall depth, and intensity) extracted from a sub-daily rainfall time series based on the inter-event time definition (IETD) method. To have a reference value of IETD, it also analyzes/computes IETD values through three methods: autocorrelation analysis, the average annual number of events analysis, and coefficient of variation analysis. Ideal for analyzing the sensitivity of IETD to characteristics of independent rainfall events. Adams B, Papa F (2000) <ISBN: 978-0-471-33217-6>. Joo J et al. (2014) <doi:10.3390/w6010045>. Restrepo-Posada P, Eagleson P (1982) <doi:10.1016/0022-1694(82)90136-6>.

This package provides advanced functions for image processing based on the package imager'.

This package provides efficient implementation of the Isolate-Detect methodology for the consistent estimation of the number and location of multiple change-points in one-dimensional data sequences from the "deterministic + noise" model. For details on the Isolate-Detect methodology, please see Anastasiou and Fryzlewicz (2018) <https://docs.wixstatic.com/ugd/24cdcc_6a0866c574654163b8255e272bc0001b.pdf>. Currently implemented scenarios are: piecewise-constant signal with Gaussian noise, piecewise-constant signal with heavy-tailed noise, continuous piecewise-linear signal with Gaussian noise, continuous piecewise-linear signal with heavy-tailed noise.

Generalized Odds Rate Hazards (GORH) model is a flexible model of fitting survival data, including the Proportional Hazards (PH) model and the Proportional Odds (PO) Model as special cases. This package fit the GORH model with interval censored data.

Identity by Descent (IBD) distributions in pedigrees. A Hidden Markov Model is used to compute identity coefficients, simulate IBD segments and to derive the distribution of total IBD sharing and segment count across chromosomes. The methods are applied in Kruijver (2025) <doi:10.3390/genes16050492>. The probability that the total IBD sharing is zero can be computed using the method of Donnelly (1983) <doi:10.1016/0040-5809(83)90004-7>.

Geostatistical interpolation has traditionally been done by manually fitting a variogram and then interpolating. Here, we introduce classes and methods that can do this interpolation automatically. Pebesma et al (2010) gives an overview of the methods behind and possible usage <doi:10.1016/j.cageo.2010.03.019>.

This package implements some item response models for multiple ratings, including the hierarchical rater model, conditional maximum likelihood estimation of linear logistic partial credit model and a wrapper function to the commercial FACETS program. See Robitzsch and Steinfeld (2018) for a description of the functionality of the package. See Wang, Su and Qiu (2014; <doi:10.1111/jedm.12045>) for an overview of modeling alternatives.

Calculate the injury severity score (ISS) based on the dictionary in ICDPIC from <https://ideas.repec.org/c/boc/bocode/s457028.html>. The original code was written in STATA 11'. The original STATA code was written by David Clark, Turner Osler and David Hahn. I implement the same logic for easier access. Ref: David E. Clark & Turner M. Osler & David R. Hahn, 2009. "ICDPIC: Stata module to provide methods for translating International Classification of Diseases (Ninth Revision) diagnosis codes into standard injury categories and/or scores," Statistical Software Components S457028, Boston College Department of Economics, revised 29 Oct 2010.

This package provides functions to analyse missing value mechanisms and to impute data sets in the context of bottom-up MS-based proteomics.

This package provides a monthly summary of Iowa liquor (class E) sales from January 2015 to October 2020. See the package website for more information, documentation and examples. Data source: Iowa Data portal <https://data.iowa.gov/resource/m3tr-qhgy.csv>.

This network estimation procedure eLasso, which is based on the Ising model, combines l1-regularized logistic regression with model selection based on the Extended Bayesian Information Criterion (EBIC). EBIC is a fit measure that identifies relevant relationships between variables. The resulting network consists of variables as nodes and relevant relationships as edges. Can deal with binary data.

Merges and downloads SPSS data from different International Large-Scale Assessments (ILSA), including: Trends in International Mathematics and Science Study (TIMSS), Progress in International Reading Literacy Study (PIRLS), and others.

This package provides function to read data from the Igor Pro data analysis program by Wavemetrics'. The data formats supported are Igor packed experiment format ('pxp') and Igor binary wave ('ibw'). See: <https://www.wavemetrics.com/> for details. Also includes functions to load special pxp files produced by the Igor Pro Neuromatic and Nclamp packages for recording and analysing neuronal data. See <https://github.com/SilverLabUCL/NeuroMatic> for details.

This package provides functions to fetch market data, search historical prices, execute trades, and get account details from the IG Trading REST API <https://labs.ig.com>. Returns tidy tibbles for easy analysis. Trading contracts for difference (CFDs), options and spread bets carries a high risk of losing money. This package is not financial or trading advice.

This package provides a basic set of compact widgets for shiny apps which occupy less space and can appear inline with surrounding text.