Combining genomic prediction with Monte Carlo simulation, three different strategies are implemented to select parental lines for multiple traits in plant breeding. The selection strategies include (i) GEBV-O considers only genomic estimated breeding values (GEBVs) of the candidate individuals; (ii) GD-O considers only genomic diversity (GD) of the candidate individuals; and (iii) GEBV-GD considers both GEBV and GD. The above method can be seen in Chung PY, Liao CT (2020) <doi:10.1371/journal.pone.0243159>. Multi-trait genomic best linear unbiased prediction (MT-GBLUP) model is used to simultaneously estimate GEBVs of the target traits, and then a selection index is adopted to evaluate the composite performance of an individual.

This network estimation procedure eLasso, which is based on the Ising model, combines l1-regularized logistic regression with model selection based on the Extended Bayesian Information Criterion (EBIC). EBIC is a fit measure that identifies relevant relationships between variables. The resulting network consists of variables as nodes and relevant relationships as edges. Can deal with binary data.

Interaction and analysis of multiple response data, along with other tools for analysing these types of data including missing value analysis and calculation of standard errors for a range of covariance matrix results (proportions, multinomial, independent samples, and multiple response).

Implementation of tandem clustering with invariant coordinate selection with different scatter matrices and several choices for the selection of components as described in Alfons, A., Archimbaud, A., Nordhausen, K.and Ruiz-Gazen, A. (2024) <doi:10.1016/j.ecosta.2024.03.002>.

This package provides examples of code for analyzing data or accomplishing tasks that may be useful to institutional or educational researchers.

Allows an interactive assessment of the timing of interim analyses. The algorithm simulates both the recruitment and treatment/event phase of a clinical trial based on the package interim'.

This package provides a set of tools to i) identify geographic areas with significant change over time in drug utilization, and ii) characterize common change over time patterns among the time series for multiple geographic areas. For reference, see below: 1. Song, J., Carey, M., Zhu, H., Miao, H., Ram´ırez, J. C., & Wu, H. (2018) <doi:10.1504/IJCBDD.2018.10011910> 2. Wu, S., Wu, H. (2013) <doi:10.1186/1471-2105-14-6> 3. Carey, M., Wu, S., Gan, G. & Wu, H. (2016) <doi:10.1016/j.idm.2016.07.001>.

This package provides access to the Idea Data Center (IDC) application for conducting nonresponse bias analysis (NRBA). The IDC NRBA app is an interactive, browser-based Shiny application that can be used to analyze survey data with respect to response rates, representativeness, and nonresponse bias. This app provides a user-friendly interface to statistical methods implemented by the nrba package. Krenzke, Van de Kerckhove, and Mohadjer (2005) <http://www.asasrms.org/Proceedings/y2005/files/JSM2005-000572.pdf> and Lohr and Riddles (2016) <https://www150.statcan.gc.ca/n1/en/pub/12-001-x/2016002/article/14677-eng.pdf?st=q7PyNsGR> provide an overview of the statistical methods implemented in the application.

This package provides methods for testing the equality of dependent intraclass correlation coefficients (ICCs) estimated using linear mixed-effects models. Several of the implemented approaches are based on the work of Donner and Zou (2002) <doi:10.1111/1467-9884.00324>.

Analyzes raw abundance data from a cellular thermal shift experiment and calculates melt temperatures and melt shifts for each protein in the experiment. McCracken (2022) <doi:10.1101/2022.12.30.522131>.

Generalised linear models via the iteratively reweighted least squares algorithm. The functions perform logistic, Poisson and Gamma regression (ISBN:9780412317606), either for a single model or many regression models in a column-wise fashion.

This package provides functions to perform robust nonparametric survival analysis with right censored data using a prior near-ignorant Dirichlet Process. Mangili, F., Benavoli, A., de Campos, C.P., Zaffalon, M. (2015) <doi:10.1002/bimj.201500062>.

Creation of tables of summary statistics or counts for clinical data (for TLFs'). These tables can be exported as in-text table (with the flextable package) for a Clinical Study Report (Word format) or a topline presentation (PowerPoint format), or as interactive table (with the DT package) to an html document for clinical data review.

Assists in generating binary clustered data, estimates of Intracluster Correlation coefficient (ICC) for binary response in 16 different methods, and 5 different types of confidence intervals.

The goal of image2data is to extract images and return them into a data set, especially for teaching data manipulation and data visualization. Basically, the eponymous function takes an image file ('png', tiff', jpeg', bmp') and turn it into a data set, pixels being rows (subjects) and columns (variables) being their coordinate positions (x- and y-axis) and their respective color (in hex codes). The function can return a complete image or a range of color (i.e., contour, silhouette). The data can then be manipulated as would any data set by either creating other related variables (to hide the image) or as a genuine toy data set.

This package provides a shiny application to assist in phytosanitary inspections. It generates a diagram of pallets in a lot, highlights the units to be sampled, and documents them based on the selected sampling method (simple random or systematic sampling).

An implementation of the initial guided analytics for parameter testing and controlband extraction framework. Functions are available for continuous and categorical target variables as well as for generating standardized reports of the conducted analysis. See <https://github.com/stefan-stein/igate> for more information on the technology.

Generate plots based on the Item Pool Visualization concept for latent constructs. Item Pool Visualizations are used to display the conceptual structure of a set of items (self-report or psychometric). Dantlgraber, Stieger, & Reips (2019) <doi:10.1177/2059799119884283>.

This package provides a collection of tools for detecting influential cases in generalized mixed effects models. It analyses models that were estimated using lme4'. The basic rationale behind identifying influential data is that when single units are omitted from the data, models based on these data should not produce substantially different estimates. To standardize the assessment of how influential a (single group of) observation(s) is, several measures of influence are common practice, such as Cook's Distance. In addition, we provide a measure of percentage change of the fixed point estimates and a simple procedure to detect changing levels of significance.

Simulation of segments shared identical-by-descent (IBD) by pedigree members. Using sex specific recombination rates along the human genome (Halldorsson et al. (2019) <doi:10.1126/science.aau1043>), phased chromosomes are simulated for all pedigree members. Applications include calculation of realised relatedness coefficients and IBD segment distributions. ibdsim2 is part of the pedsuite collection of packages for pedigree analysis. A detailed presentation of the pedsuite', including a separate chapter on ibdsim2', is available in the book Pedigree analysis in R (Vigeland, 2021, ISBN:9780128244302). A Shiny app for visualising and comparing IBD distributions is available at <https://magnusdv.shinyapps.io/ibdsim2-shiny/>.

This package provides a comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on tidyverse <https://tidyverse.tidyverse.org/> principles and making use of genotype list string (GL string, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL string; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL string; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL string. This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.

This package provides a tool to calculate and plot estimates from models in which an interaction between the main predictor and a continuous covariate has been specified. Methods used in the package refer to Harrell Jr FE (2015, ISBN:9783319330396); Durrleman S, Simon R. (1989) <doi:10.1002/sim.4780080504>; Greenland S. (1995) <doi:10.1097/00001648-199507000-00005>.

Sieve semiparametric likelihood methods for analyzing interval-censored failure time data from an outcome-dependent sampling (ODS) design and from a case-cohort design. Zhou, Q., Cai, J., and Zhou, H. (2018) <doi:10.1111/biom.12744>; Zhou, Q., Zhou, H., and Cai, J. (2017) <doi:10.1093/biomet/asw067>.

To integrate multiple GSEA studies, we propose a hybrid strategy, iGSEA-AT, for choosing random effects (RE) versus fixed effect (FE) models, with an attempt to achieve the potential maximum statistical efficiency as well as stability in performance in various practical situations. In addition to iGSEA-AT, this package also provides options to perform integrative GSEA with testing based on a FE model (iGSEA-FE) and testing based on a RE model (iGSEA-RE). The approaches account for different set sizes when testing a database of gene sets. The function is easy to use, and the three approaches can be applied to both binary and continuous phenotypes.