This package provides a feasible framework for mutation analysis and reverse transcription polymerase chain reaction (RT-PCR) assay evaluation of COVID-19, including mutation profile visualization, statistics and mutation ratio of each assay. The mutation ratio is conducive to evaluating the coverage of RT-PCR assays in large-sized samples. Mercatelli, D. and Giorgi, F. M. (2020) <doi:10.20944/preprints202004.0529.v1>.

Useful tools for fitting, validating, and forecasting of practical convolution-closed time series models for low counts are provided. Marginal distributions of the data can be modelled via Poisson and Generalized Poisson innovations. Regression effects can be incorporated through time varying innovation rates. The models are described in Jung and Tremayne (2011) <doi:10.1111/j.1467-9892.2010.00697.x> and the model assessment tools are presented in Czado et al. (2009) <doi:10.1111/j.1541-0420.2009.01191.x> and, Tsay (1992) <doi:10.2307/2347612>.

Fit a CoxSEI (Cox type Self-Exciting Intensity) model to right-censored counting process data.

Adjusts the loglikelihood of common econometric models for clustered data based on the estimation process suggested in Chandler and Bate (2007) <doi:10.1093/biomet/asm015>, using the chandwich package <https://cran.r-project.org/package=chandwich>, and provides convenience functions for inference on the adjusted models.

This package contains a function, also called cchs', that calculates Estimator III of Borgan et al (2000), <DOI:10.1023/A:1009661900674>. This estimator is for fitting a Cox proportional hazards model to data from a case-cohort study where the subcohort was selected by stratified simple random sampling.

Calculation of gas transport properties (viscosity, diffusion, thermal conductivity) using Chapman-Enskok theory (Chapman 1918, <doi:10.1098/rsta.1918.0005>) and of the second virial coefficient (Vargas et al. 2001, <doi:10.1016/s0378-4371(00)00362-9>) using the Lennard-Jones (12-6) potential. Up to the third order correction is taken into account for viscosity and thermal conductivity. It is also possible to calculate the binary diffusion coefficients of polar and non-polar gases in non-polar bath gases (Brown et al. 2011, <doi:10.1016/j.pecs.2010.12.001>). 16 collision integrals are calculated with four digit accuracy over the reduced temperature range [0.3, 400] using an interpolation function of Kim and Monroe (2014, <doi:10.1016/j.jcp.2014.05.018>).

This package provides a generic sleepâ wake cycle detection algorithm for analyzing unlabeled actigraphy data. The algorithm has been validated against event markers using data from the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep study, and its methodological details are described in Chen and Sun (2024) <doi:10.1098/rsos.231468>. The package provides functions to estimate sleep metrics (e.g., sleep and wake onset times) and circadian rhythm metrics (e.g., mesor, phasor, interdaily stability, intradaily variability), as well as tools for screening actigraphy quality, fitting cosinor models, and performing parametric change point detection. The workflow can also be used to segment long actigraphy sequences into regularized structures for physical activity research.

Estimation of sparse nonlinear functions in nonparametric regression using component selection and smoothing. Designed for the analysis of high-dimensional data, the models support various data types, including exponential family models and Cox proportional hazards models. The methodology is based on Lin and Zhang (2006) <doi:10.1214/009053606000000722>.

This package provides a wrapper for the U.S. Census Bureau APIs that returns data frames of Census data and metadata. Available datasets include the Decennial Census, American Community Survey, Small Area Health Insurance Estimates, Small Area Income and Poverty Estimates, Population Estimates and Projections, and more.

Calculate the distance between single-arm observational studies using covariate information to remove heterogeneity in Network Meta-Analysis (NMA) of randomized clinical trials. Facilitate the inclusion of observational data in NMA, enhancing the comprehensiveness and robustness of comparative effectiveness research. Schmitz (2018) <doi:10.1186/s12874-018-0509-7>.

This package produces formal landscape PDF certificates with configurable color themes, optional logos, decorative borders, laurels, and corner ornaments. Built on grid with no external LaTeX or Quarto dependency. Suitable for academic awards, professional recognition, and similar uses.

Calculates predictions from generalized estimating equations and internally cross-validates them using the logarithmic, quadratic and spherical proper scoring rules; Kung-Yee Liang and Scott L. Zeger (1986) <doi:10.1093/biomet/73.1.13>.

Frequentist statistical inference for cluster randomised trials with multiple outcomes that controls the family-wise error rate and provides nominal coverage of confidence sets. A full description of the methods can be found in Watson et al. (2023) <doi:10.1002/sim.9831>.

In randomized controlled trial (RCT), balancing covariate is often one of the most important concern. CARM package provides functions to balance the covariates and generate allocation sequence by covariate-adjusted Adaptive Randomization via Mahalanobis-distance (ARM) for RCT. About what ARM is and how it works please see Y. Qin, Y. Li, W. Ma, H. Yang, and F. Hu (2024). "Adaptive randomization via Mahalanobis distance" Statistica Sinica. <doi:10.5705/ss.202020.0440>. In addition, the package is also suitable for the randomization process of multi-arm trials. For details, please see Yang H, Qin Y, Wang F, et al. (2023). "Balancing covariates in multi-arm trials via adaptive randomization" Computational Statistics & Data Analysis.<doi:10.1016/j.csda.2022.107642>.

This package provides tools for extracting occurrences, assessing potential driving factors, predicting occurrences, and quantifying impacts of compound events in hydrology and climatology. Please see Hao Zengchao et al. (2022) <doi:10.1016/j.earscirev.2022.104241>.

This package provides functions for fitting GEV and POT (via point process fitting) models for extremes in climate data, providing return values, return probabilities, and return periods for stationary and nonstationary models. Also provides differences in return values and differences in log return probabilities for contrasts of covariate values. Functions for estimating risk ratios for event attribution analyses, including uncertainty. Under the hood, many of the functions use functions from extRemes', including for fitting the statistical models. Details are given in Paciorek, Stone, and Wehner (2018) <doi:10.1016/j.wace.2018.01.002>.

Identification of cardinal dates (begin, time of maximum, end of mass developments) in ecological time series using fitted Weibull functions.

The Concordance Test is a non-parametric method for testing whether two o more samples originate from the same distribution. It extends the Kendall Tau correlation coefficient when there are only two groups. For details, see Alcaraz J., Anton-Sanchez L., Monge J.F. (2022) The Concordance Test, an Alternative to Kruskal-Wallis Based on the Kendall-tau Distance: An R Package. The R Journal 14, 26â 53 <doi:10.32614/RJ-2022-039>.

This package creates ggplot2 Cumulative Residual (CURE) plots to check the goodness-of-fit of a count model; or the tables to create a customized version. A dataset of crashes in Washington state is available for illustrative purposes.

While data from randomized experiments remain the gold standard for causal inference, estimation of causal estimands from observational data is possible through various confounding adjustment methods. However, the challenge of unmeasured confounding remains a concern in causal inference, where failure to account for unmeasured confounders can lead to biased estimates of causal estimands. Sensitivity analysis within the framework of causal inference can help adjust for possible unmeasured confounding. In `causens`, three main methods are implemented: adjustment via sensitivity functions (Brumback, Hernán, Haneuse, and Robins (2004) <doi:10.1002/sim.1657> and Li, Shen, Wu, and Li (2011) <doi:10.1093/aje/kwr096>), Bayesian parametric modelling and Monte Carlo approaches (McCandless, Lawrence C and Gustafson, Paul (2017) <doi:10.1002/sim.7298>).

Variable selection for Gaussian model-based clustering as implemented in the mclust package. The methodology allows to find the (locally) optimal subset of variables in a data set that have group/cluster information. A greedy or headlong search can be used, either in a forward-backward or backward-forward direction, with or without sub-sampling at the hierarchical clustering stage for starting mclust models. By default the algorithm uses a sequential search, but parallelisation is also available.

An end-to-end framework that enables users to implement various descriptive studies for a given set of target and outcome cohorts for data mapped to the Observational Medical Outcomes Partnership Common Data Model.

This package provides methods and data for color science - color conversions by observer, illuminant, and gamma. Color matching functions and chromaticity diagrams. Color indices, color differences, and spectral data conversion/analysis. This package is deprecated and will someday be removed; for reasons and details please see the README file.

Fast categorization of items based on external code data identified by regular expressions. A typical use case considers patient with medically coded data, such as codes from the International Classification of Diseases ('ICD') or the Anatomic Therapeutic Chemical ('ATC') classification system. Functions of the package relies on a triad of objects: (1) case data with unit id:s and possible dates of interest; (2) external code data for corresponding units in (1) and with optional dates of interest and; (3) a classification scheme ('classcodes object) with regular expressions to identify and categorize relevant codes from (2). It is easy to introduce new classification schemes ('classcodes objects) or to use default schemes included in the package. Use cases includes patient categorization based on comorbidity indices such as Charlson', Elixhauser', RxRisk V', or the comorbidity-polypharmacy score (CPS), as well as adverse events after hip and knee replacement surgery.