Implementation of the Monothetic Clustering algorithm (Chavent, 1998 <doi:10.1016/S0167-8655(98)00087-7>) on continuous data sets. A lot of extensions are included in the package, including applying Monothetic clustering on data sets with circular variables, visualizations with the results, and permutation and cross-validation based tests to support the decision on the number of clusters.

Mask ranges based on expert knowledge or remote sensing layers. These tools can be combined to quantitatively and reproducibly generate a new map or to update an existing map. Methods include expert opinion and data-driven tools to generate thresholds for binary masks.

Fits the Multiple Random Dot Product Graph Model and performs a test for whether two networks come from the same distribution. Both methods are proposed in Nielsen, A.M., Witten, D., (2018) "The Multiple Random Dot Product Graph Model", arXiv preprint <arXiv:1811.12172> (Submitted to Journal of Computational and Graphical Statistics).

Inference of Multiscale graphical models with neighborhood selection approach. The method is based on solving a convex optimization problem combining a Lasso and fused-group Lasso penalties. This allows to infer simultaneously a conditional independence graph and a clustering partition. The optimization is based on the Continuation with Nesterov smoothing in a Shrinkage-Thresholding Algorithm solver (Hadj-Selem et al. 2018) <doi:10.1109/TMI.2018.2829802> implemented in python.

This package provides functions, which make matrix creation conciser (such as the core package's function m() for rowwise matrix definition or runifm() for random value matrices). Allows to set multiple matrix values at once, by using list of formulae. Provides additional matrix operators and dedicated plotting function.

In the MeLiDos field study, personal light exposure data were collected in 9 sites, 7 countries, and 196 participants following the Guidolin et al. (2024) <doi:10.1186/s12889-024-20206-4> protocol. Data originate from wearable devices collecting personal light exposure at the eye level, chest, and the wrist. Questionnaires were collected via REDCap and contain demographic information as well as chronotype, current conditions, sleep diaries, wear logs, and many more. This package makes loading the data from the respective repositories (<https://github.com/MeLiDosProject>) into R a breeze. It further contains some quality of life functions for label handling and data from REDCap'.

This package implements differential methylation region (DMR) detection using a multistage Markov chain Monte Carlo (MCMC) algorithm based on the alpha-skew generalized normal (ASGN) distribution. Version 0.2.0 removes the Anderson-Darling test stage, improves computational efficiency of the core ASGN and multistage MCMC routines, and adds convenience functions for summarizing and visualizing detected DMRs. The methodology is based on Yang (2025) <https://www.proquest.com/docview/3218878972>.

Model infectious disease dynamics in populations with multiple subgroups having different vaccination rates, transmission characteristics, and contact patterns. Calculate final and intermediate outbreak sizes, form age-structured contact models with automatic fetching of U.S. census data, and explore vaccination scenarios with an interactive shiny dashboard for a model with two subgroups, as described in Nguyen et al. (2024) <doi:10.1016/j.jval.2024.03.039> and Duong et al. (2026) <doi:10.1093/ofid/ofaf695.217>.

This package provides functions for fitting various models to capture-recapture data including mixed-effects Cormack-Jolly-Seber(CJS) and multistate models and the multi-variate state model structure for survival estimation and POPAN structured Jolly-Seber models for abundance estimation. There are also Hidden Markov model (HMM) implementations of CJS and multistate models with and without state uncertainty and a simulation capability for HMM models.

Gene selection based on variance using the marginal distributions of gene profiles that characterized by a mixture of three-component multivariate distributions. Please see the reference: Li X, Fu Y, Wang X, DeMeo DL, Tantisira K, Weiss ST, Qiu W. (2018) <doi:10.1155/2018/6591634>.

We provide the framework to analyze multiresolution partitions (e.g. country, provinces, subdistrict) where each individual data point belongs to only one partition in each layer (e.g. i belongs to subdistrict A, province P, and country Q). We assume that a partition in a higher layer subsumes lower-layer partitions (e.g. a nation is at the 1st layer subsumes all provinces at the 2nd layer). Given N individuals that have a pair of real values (x,y) that generated from independent variable X and dependent variable Y. Each individual i belongs to one partition per layer. Our goal is to find which partitions at which highest level that all individuals in the these partitions share the same linear model Y=f(X) where f is a linear function. The framework deploys the Minimum Description Length principle (MDL) to infer solutions. The publication of this package is at Chainarong Amornbunchornvej, Navaporn Surasvadi, Anon Plangprasopchok, and Suttipong Thajchayapong (2021) <doi:10.1145/3424670>.

This package provides common components (classes, methods, documentation) for packages that conduct meta-analytic corrections and sensitivity analyses for within-study and/or across-study biases in meta-analysis. See the packages PublicationBias', phacking', and multibiasmeta'. These package implement methods described in, respectively: Mathur & VanderWeele (2020) <doi:10.31219/osf.io/s9dp6>; Mathur (2022) <doi:10.31219/osf.io/ezjsx>; Mathur (2022) <doi:10.31219/osf.io/u7vcb>.

Difference scaling is a method for scaling perceived supra-threshold differences. The package contains functions that allow the user to design and run a difference scaling experiment, to fit the resulting data by maximum likelihood and test the internal validity of the estimated scale.

Fit finite mixture distribution models to grouped data and conditional data by maximum likelihood using a combination of a Newton-type algorithm and the EM algorithm.

This package provides methods for detecting signals related to (adverse event, medical product e.g. drugs, vaccines) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions. For more details please see Liu A., Mukhopadhyay R., and Markatou M. <doi:10.48550/arXiv.2410.01168>.

The MCC-F1 analysis is a method to evaluate the performance of binary classifications. The MCC-F1 curve is more reliable than the Receiver Operating Characteristic (ROC) curve and the Precision-Recall (PR)curve under imbalanced ground truth. The MCC-F1 analysis also provides the MCC-F1 metric that integrates classifier performance over varying thresholds, and the best threshold of binary classification.

Based on the input data an n-dimensional cube with sub cells of user specified side length is created. The number of sample points which fall in each sub cube is counted, and with the cell volume and overall sample size an empirical probability can be computed. A number of cubes of higher resolution can be superimposed. The basic method stems from J.L. Bentley in "Multidimensional Divide and Conquer". J. L. Bentley (1980) <doi:10.1145/358841.358850>. Furthermore a simple kernel density estimation method is made available, as well as an expansion of Bentleys method, which offers a kernel approach for the grid method.

This package implements a minimum-spanning-tree-based heuristic for k-means clustering using a union-find disjoint set and the algorithm in Kruskal (1956) <doi:10.1090/S0002-9939-1956-0078686-7>.

This package provides a system for testing differential effects among treatments in case of Randomised Block Design and Latin Square Design when there is one missing observation. Methods for this process are as described in A.M.Gun,M.K.Gupta and B.Dasgupta(2019,ISBN:81-87567-81-3).

With foundations on the work by Goutali and Chebana (2024) <doi:10.1016/j.envsoft.2024.106090>, this package contains various univariate and multivariate trend tests. The main functions regard the Multivariate Dependence Trend and Multivariate Overall Trend tests as proposed by Goutali and Chebana (2024), as well as a plotting function that proves useful as a summary and complement of the tests. Although many packages and methods carry univariate tests, the Mann-Kendall and Spearman's rho test implementations are included in the package with an adapted version to hydrological formulation (e.g. as in Rao and Hamed 1998 <doi:10.1016/S0022-1694(97)00125-X> or Chebana 2022 <doi:10.1016/C2021-0-01317-1>). For better understanding of the example use of the functions, three datasets are included. These are synthetic data and shouldn't be used beyond that purpose.

This package provides a comprehensive suite of estimation tools for meanimiles, a general class of (risk) functionals. This package includes nonparametric estimators for univariate meanimile evaluation, copula-based estimation for portfolio risk aggregation (full parametric, semiparametric, and nonparametric), and novel estimators for meanimiles in regression settings. Following the articles D. Debrauwer, I. Gijbels, and K. Herrmann (2025) <doi:10.1214/25-EJS2391>, D. Debrauwer and I. Gijbels (2026) <doi:10.1007/s00184-026-01022-9>.

This package provides tools for analyzing metabolic pathway completeness, abundance, and transcripts using KEGG Orthology (KO) data from (meta)genomic and (meta)transcriptomic studies. Supports both completeness (presence/absence) and abundance-weighted analyses. Includes built-in KEGG reference datasets. For more details see Li et al. (2023) <doi:10.1038/s41467-023-42193-7>.

More data sets used for demonstrating or testing model-related packages are contained in this package. The data sets are downloaded and cached, allowing for more and bigger data sets.

This package provides a generalised workflow for Matching-Adjusted Indirect Comparison (MAIC) analysis, which supports both anchored and non-anchored MAIC methods. In MAIC, unbiased trial outcome comparison is achieved by weighting the subject-level outcomes of the intervention trial so that the weighted aggregate measures of prognostic or effect-modifying variables match those of the comparator trial. Measurements supported include time-to-event (e.g., overall survival) and binary (e.g., objective tumor response). The method is described in Signorovitch et al. (2010) <doi:10.2165/11538370-000000000-00000> and Signorovitch et al. (2012) <doi:10.1016/j.jval.2012.05.004>.