This package provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including: - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <doi:10.1200/PO.20.00257>), - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <doi:10.1002/pst.1864>), - EffTox (Thall, P. F., & Cook, J. D. (2004) <doi:10.1111/j.0006-341X.2004.00218.x>), - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <doi:10.1080/10543406.2020.1818250>), - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) <doi:10.1177/0962280220977009>), - STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) <doi:10.1002/sim.7428>), - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>), - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) <doi:10.1002/sim.8922>). Includes flexible simulation parameters that allow researchers to efficiently compute operating characteristics under various fixed and random trial scenarios and export the results.

An R package for polygenic trait analysis.

Simulate pedigree, genetic merits and phenotypes with random/non-random matings followed by random/non-random selection with different intensities and patterns in males and females. Genotypes can be simulated for a given pedigree, or an appended pedigree to an existing pedigree with genotypes. Mrode, R. A. (2005) <ISBN:9780851989969, 0851989969>; Nilforooshan, M.A. (2022) <doi:10.37496/rbz5120210131>.

This package contains functions to compute and plot confidence distributions, confidence densities, p-value functions and s-value (surprisal) functions for several commonly used estimates. Instead of just calculating one p-value and one confidence interval, p-value functions display p-values and confidence intervals for many levels thereby allowing to gauge the compatibility of several parameter values with the data. These methods are discussed by Infanger D, Schmidt-Trucksäss A. (2019) <doi:10.1002/sim.8293>; Poole C. (1987) <doi:10.2105/AJPH.77.2.195>; Schweder T, Hjort NL. (2002) <doi:10.1111/1467-9469.00285>; Bender R, Berg G, Zeeb H. (2005) <doi:10.1002/bimj.200410104> ; Singh K, Xie M, Strawderman WE. (2007) <doi:10.1214/074921707000000102>; Rothman KJ, Greenland S, Lash TL. (2008, ISBN:9781451190052); Amrhein V, Trafimow D, Greenland S. (2019) <doi:10.1080/00031305.2018.1543137>; Greenland S. (2019) <doi:10.1080/00031305.2018.1529625> and Rafi Z, Greenland S. (2020) <doi:10.1186/s12874-020-01105-9>.

Using the Bayesian state-space approach, we developed a continuous development model to quantify dynamic incremental changes in the response variable. While the model was originally developed for daily changes in forest green-up, the model can be used to predict any similar process. The CDM can capture both timing and rate of nonlinear processes. Unlike statics methods, which aggregate variations into a single metric, our dynamic model tracks the changing impacts over time. The CDM accommodates nonlinear responses to variation in predictors, which changes throughout development.

Extends the S3 generic function knit_print() in knitr to automatically print some objects using an appropriate format such as Markdown or LaTeX. For example, data frames are automatically printed as tables, and the help() pages can also be rendered in knitr documents.

This package contains a dataset of words used in 15.000 randomly extracted pages from the Portuguese Wikipedia (<https://pt.wikipedia.org/>).

Prism <https://prismjs.com/> is a lightweight, extensible syntax highlighter, built with modern web standards in mind. This package provides server-side rendering in R using V8 such that no JavaScript library is required in the resulting HTML documents. Over 400 languages are supported.

Treats the proximity matrices produced by tree ensembles as first-class statistical objects rather than as model by-products. Provides a unified extractor across ensemble engines, in-bag and out-of-bag definitions, transformations to dissimilarities with metric diagnostics, corrections that make an indefinite proximity usable as a kernel, and permutation inference for comparing two proximity matrices or partitioning one across the terms of a design. Also provides a Nystrom approximation, a thresholded sparse representation and a streaming form that never allocates the matrix at all, for samples too large to hold it, measures how far the proximity moves between replicates of the ensemble, and draws each object through ggplot2': the seriated matrix, the configuration it implies, and the thresholded graph with its communities.

This package provides a collection of functions for modelling mutations in pedigrees with marker data, as used e.g. in likelihood computations with microsatellite data. Implemented models include equal, proportional and stepwise models, as well as random models for experimental work, and custom models allowing the user to apply any valid mutation matrix. Allele lumping is done following the lumpability criteria of Kemeny and Snell (1976), ISBN:0387901922.

This package provides a comprehensive library for colour vectors and colour palettes using a new family of colour classes (palettes_colour and palettes_palette) that always print as hex codes with colour previews. Capabilities include: formatting, casting and coercion, extraction and updating of components, plotting, colour mixing arithmetic, and colour interpolation.

This package implements IV-estimator and Bayesian estimator for linear-in-means Spatial Autoregressive (SAR) model (see LeSage, 1997 <doi:10.1177/016001769702000107>; Lee, 2004 <doi:10.1111/j.1468-0262.2004.00558.x>; Bramoullé et al., 2009 <doi:10.1016/j.jeconom.2008.12.021>), while assuming that only a partial information about the network structure is available. Examples are when the adjacency matrix is not fully observed or when only consistent estimation of the network formation model is available (see Boucher and Houndetoungan, 2025 <doi:10.48550/arXiv.2509.08145>).

Assessment for statistically-based PPQ sampling plan, including calculating the passing probability, optimizing the baseline and high performance cutoff points, visualizing the PPQ plan and power dynamically. The analytical idea is based on the simulation methods from the textbook Burdick, R. K., LeBlond, D. J., Pfahler, L. B., Quiroz, J., Sidor, L., Vukovinsky, K., & Zhang, L. (2017). Statistical Methods for CMC Applications. In Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry (pp. 227-250). Springer, Cham.

This package provides functionality to support data preparation and exploration for palaeobiological analyses, improving code reproducibility and accessibility. The wider aim of palaeoverse is to bring the palaeobiological community together to establish agreed standards. The package currently includes functionality for data cleaning, binning (time and space), exploration, summarisation and visualisation. Reference datasets (i.e. Geological Time Scales <https://stratigraphy.org/chart/>) and auxiliary functions are also provided. Details can be found in: Jones et al., (2023) <doi: 10.1111/2041-210X.14099>.

Tailoring the optimal biomarker(s) for disease screening or diagnosis based on subjects individual characteristics.

When working with big data sets, RAM conservation is critically important. However, it is not always enough to just monitor the size of the objects created. So-called "copy-on-modify" behavior, characteristic of R, means that some expressions or functions may require an unexpectedly large amount of RAM overhead. For example, replacing a single value in a matrix duplicates that matrix in the back-end, making this task require twice as much RAM as that used by the matrix itself. This package makes it easy to monitor the total and peak RAM used so that developers can quickly identify and eliminate RAM hungry code.

An implementation of a hybrid method of person-oriented method and perturbation on the model. Pompom is the initials of the two methods. The hybrid method will provide a multivariate intraindividual variability metric (iRAM). The person-oriented method used in this package refers to uSEM (unified structural equation modeling, see Kim et al., 2007, Gates et al., 2010 and Gates et al., 2012 for details). Perturbation on the model was conducted according to impulse response analysis introduced in Lutkepohl (2007). Kim, J., Zhu, W., Chang, L., Bentler, P. M., & Ernst, T. (2007) <doi:10.1002/hbm.20259>. Gates, K. M., Molenaar, P. C. M., Hillary, F. G., Ram, N., & Rovine, M. J. (2010) <doi:10.1016/j.neuroimage.2009.12.117>. Gates, K. M., & Molenaar, P. C. M. (2012) <doi:10.1016/j.neuroimage.2012.06.026>. Lutkepohl, H. (2007, ISBN:3540262393).

Perform tasks commonly encountered when preparing and analysing demographic data. Some functions are intended for end users, and others for developers. Includes functions for working with life tables.

Safely extracts and coerces values from a Power BI parameter table (one row, multiple columns) without string concatenation or injection of raw values into scripts.

Computes sample size and power for causal inference studies that use propensity score (PS) weighting. Supports continuous, binary, and time-to-event (survival) outcomes under four estimands: average treatment effect (ATE), average treatment effect on the treated (ATT), average treatment effect on the controls (ATC), and average treatment effect on the overlap population (ATO). For continuous and binary outcomes, the asymptotic variance of the Hajek inverse probability weighting estimator is derived under a logit-normal propensity score model, approximated by a Beta distribution matched through the Bhattacharyya overlap coefficient. For survival outcomes, the asymptotic variance of the propensity-score- weighted partial likelihood estimator is used for randomized trials and observational studies. The Schoenfeld formula is also available for randomized trial settings.

Create a parallel coordinates plot, using `htmlwidgets` package and `d3.js`.

Engineered features and "helper" functions ancillary to the public.ctn0094data package, extending this package for ease of use (see <https://CRAN.R-project.org/package=public.ctn0094data>). This public.ctn0094data package contains harmonized datasets from some of the National Institute of Drug Abuse's Clinical Trials Network (NIDA's CTN) projects. Specifically, the CTN-0094 project is to harmonize and de-identify clinical trials data from the CTN-0027, CTN-0030, and CTN-51 studies for opioid use disorder. This current version is built from public.ctn0094data v. 1.0.6.

Generates sequential, diverging and categorical colour palettes from a single seed colour in OKLCH (the cylindrical lightness-chroma-hue representation of the Oklab perceptual colour space), with spacing measured by the CIEDE2000 colour-difference formula of the International Commission on Illumination. Audits every palette under simulated colour-vision deficiency, greyscale conversion, the standard Red Green Blue (sRGB) gamut and Web Content Accessibility Guidelines (WCAG) contrast. Colour-vision deficiency is simulated at severity 1.0 with the model of Machado, Oliveira and Fernandes (2009) <doi:10.1109/TVCG.2009.113>; the design rationale follows Crameri, Shephard and Heron (2020) <doi:10.1038/s41467-020-19160-7>. Mirrors the Python reference implementation maintained in the same repository and is validated against shared parity fixtures. Thresholds are configurable design rules, not established accessibility cut-offs.

References and cites R and R packages on the fly in R Markdown and Quarto'. pakret provides a minimalist API that generates preformatted citations for R and R packages, and adds their references to a .bib file directly from within your document.