Ke, B. S., Chiang, A. J., & Chang, Y. C. I. (2018) <doi:10.1080/10543406.2017.1377728> provide two theoretical methods (influence function and local influence) based on the area under the receiver operating characteristic curve (AUC) to quantify the numerical impact of each observation to the overall AUC. Alternative graphical tools, cumulative lift charts, are proposed to reveal the existences and approximate locations of those influential observations through data visualization.

This package provides a method that estimates an IV-optimal individualized treatment rule. An individualized treatment rule is said to be IV-optimal if it minimizes the maximum risk with respect to the putative IV and the set of IV identification assumptions. Please refer to <arXiv:2002.02579> for more details on the methodology and some theory underpinning the method. Function IV-PILE() uses functions in the package locClass'. Package locClass can be accessed and installed from the R-Forge repository via the following link: <https://r-forge.r-project.org/projects/locclass/>. Alternatively, one can install the package by entering the following in R: install.packages("locClass", repos="<http://R-Forge.R-project.org>")'.

Identify Cancer Dysfunctional Sub-pathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression. 2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional sub-pathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional sub-pathways.

The goal of image2data is to extract images and return them into a data set, especially for teaching data manipulation and data visualization. Basically, the eponymous function takes an image file ('png', tiff', jpeg', bmp') and turn it into a data set, pixels being rows (subjects) and columns (variables) being their coordinate positions (x- and y-axis) and their respective color (in hex codes). The function can return a complete image or a range of color (i.e., contour, silhouette). The data can then be manipulated as would any data set by either creating other related variables (to hide the image) or as a genuine toy data set.

This package provides a function to calculate infinite-jackknife-based standard errors for fixed effects parameters in brms models, handling both clustered and independent data. References: Ji et al. (2024) <doi:10.48550/arXiv.2407.09772>; Giordano et al. (2024) <doi:10.48550/arXiv.2305.06466>.

Integrated toolbox supporting common file formats used for intracranial Electroencephalography (iEEG) and deep-brain stimulation (DBS) study.

These are data and functions to support quantitative peace science research. The data are important state-year information on democracy and wealth, which require periodic updates and regular maintenance. The functions permit some exploratory and diagnostic assessment of the kinds of data in demand by the community, but do not impose many dependencies on the user.

This package provides a method to integrate molecular profiles of cancer patients (gene copy number and mRNA abundance) to identify candidate gain of function alterations. These candidate alterations can be subsequently further tested to discover cancer driver alterations. Briefly, this method tests of genomic correlates of mRNA dysregulation and prioritise those where DNA gains/amplifications are associated with elevated mRNA expression of the same gene. For details see, Haider S et al. (2016) "Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia", Genome Biology, <https://pubmed.ncbi.nlm.nih.gov/27358048/>.

This package provides tools for importing, merging, and analysing data from international assessment studies (TIMSS, PIRLS, PISA, ICILS, and PIAAC).

IRT-M is a semi-supervised approach based on Bayesian Item Response Theory that produces theoretically identified underlying dimensions from input data and a constraints matrix. The methodology is fully described in Morucci et al. (2024), "Measurement That Matches Theory: Theory-Driven Identification in Item Response Theory Models"'. Details are available at <https://www.cambridge.org/core/journals/american-political-science-review/article/measurement-that-matches-theory-theorydriven-identification-in-item-response-theory-models/395DA1DFE3DCD7B866DC053D7554A30B>.

This package provides a personalized dynamic latent factor model (Zhang et al. (2024) <doi:10.1093/biomet/asae015>) for irregular multi-resolution time series data, to interpolate unsampled measurements from low-resolution time series.

Implementation of functions to assign corresponding common job prestige scores (SIOPS, ISEI), the official job or group title and the ISCO-88 code to given ISCO-08 codes. ISCO-08 is the latest version of the International Standard Classification of Occupations which is used to organise information on labour and jobs.

This program facilitates exporting igraph graphs to the SoNIA file format.

The main purpose of this package is to generate the structure of the analysis of variance (ANOVA) table of the two-phase experiments. The user only need to input the design and the relationships of the random and fixed factors using the Wilkinson-Rogers syntax, this package can then quickly generate the structure of the ANOVA table with the coefficients of the variance components for the expected mean squares. Thus, the balanced incomplete block design and provides the efficiency factors of the fixed effects can also be studied and compared much easily.

Interfaces for choosing important predictors in supervised regression, classification, and censored regression models. Permuted importance scores (Biecek and Burzykowski (2021) <doi:10.1201/9780429027192>) can be computed for tidymodels model fits.

Plot idiograms of karyotypes, plasmids, circular chr. having a set of data.frames for chromosome data and optionally mark data. Two styles of chromosomes can be used: without or with visible chromatids. Supports micrometers, cM and Mb or any unit. Three styles of centromeres are available: triangle, rounded and inProtein; and six styles of marks are available: square (squareLeft), dots, cM (cMLeft), cenStyle, upArrow (downArrow), exProtein (inProtein); its legend (label) can be drawn inline or to the right of karyotypes. Idiograms can also be plotted in concentric circles. It is possible to calculate chromosome indices by Levan et al. (1964) <doi:10.1111/j.1601-5223.1964.tb01953.x>, karyotype indices of Watanabe et al. (1999) <doi:10.1007/PL00013869> and Romero-Zarco (1986) <doi:10.2307/1221906> and classify chromosomes by morphology Guerra (1986) and Levan et al. (1964).

Offers a pipe-friendly alternative to the dplyr functions case_when() and if_else(), as well as a number of user-friendly simplifications for common use cases. These functions accept a vector as an optional first argument, allowing conditional statements to be built using the magrittr dot operator. The functions also coerce all outputs to the same type, meaning you no longer have to worry about using specific typed variants of NA or explicitly declaring integer outputs, and evaluate outputs somewhat lazily, so you don't waste time on long operations that won't be used.

This package implements a wide range of metrics for measuring glucose control and glucose variability based on continuous glucose monitoring data. The list of implemented metrics is summarized in Rodbard (2009) <doi:10.1089/dia.2009.0015>. Additional visualization tools include time-series plots, lasagna plots and ambulatory glucose profile report.

Deconvolution of mixed tumour profiles into normal and cancer for each patient, using the ISOpure algorithm in Quon et al. Genome Medicine, 2013 5:29. Deconvolution requires mixed tumour profiles and a set of unmatched "basis" normal profiles.

Distributional regression under stochastic order restrictions for numeric and binary response variables and partially ordered covariates. See Henzi, Ziegel, Gneiting (2020) <arXiv:1909.03725>.

An instrumental variable estimator under structural cumulative additive intensity model is fitted, that leverages initial randomization as the IV. The estimator can be used to fit an additive hazards model under time to event data which handles treatment switching (treatment crossover) correctly. We also provide a consistent variance estimate.

Imputation of longitudinal categorical covariates. We use a methodological framework which ensures that the plausibility of transitions is preserved, overfitting and colinearity issues are resolved, and confounders can be utilized. See Mamouris (2023) <doi:10.1002/sim.9919> for an overview.

Computes intervention in prediction measure for assessing variable importance for random forests. See details at I. Epifanio (2017) <DOI:10.1186/s12859-017-1650-8>.

This package provides a joint mixture model has been developed by Majumdar et al. (2025) <doi:10.48550/arXiv.2412.17511> that integrates information from gene expression data and methylation data at the modelling stage to capture their inherent dependency structure, enabling simultaneous identification of differentially methylated cytosine-guanine dinucleotide (CpG) sites and differentially expressed genes. The model leverages a joint likelihood function that accounts for the nested structure in the data, with parameter estimation performed using an expectation-maximisation algorithm.