Calculates parameters of the seawater carbonate system and assists the design of ocean acidification perturbation experiments.

Fits univariate Bayesian spatial regression models for large datasets using Nearest Neighbor Gaussian Processes (NNGP) detailed in Finley, Datta, Banerjee (2022) <doi:10.18637/jss.v103.i05>, Finley, Datta, Cook, Morton, Andersen, and Banerjee (2019) <doi:10.1080/10618600.2018.1537924>, and Datta, Banerjee, Finley, and Gelfand (2016) <doi:10.1080/01621459.2015.1044091>.

One key exploratory analysis step in single-cell genomics data analysis is the prediction of features with different activity levels. For example, we want to predict differentially expressed genes (DEGs) in single-cell RNA-seq data, spatial DEGs in spatial transcriptomics data, or differentially accessible regions (DARs) in single-cell ATAC-seq data. singleCellHaystack predicts differentially active features in single cell omics datasets without relying on the clustering of cells into arbitrary clusters. singleCellHaystack uses Kullback-Leibler divergence to find features (e.g., genes, genomic regions, etc) that are active in subsets of cells that are non-randomly positioned inside an input space (such as 1D trajectories, 2D tissue sections, multi-dimensional embeddings, etc). For the theoretical background of singleCellHaystack we refer to our original paper Vandenbon and Diez (Nature Communications, 2020) <doi:10.1038/s41467-020-17900-3> and our update Vandenbon and Diez (Scientific Reports, 2023) <doi:10.1038/s41598-023-38965-2>.

Fast versions of seismic analysis functions that roll over a vector of values. See the RcppRoll package for alternative versions of basic statistical functions such as rolling mean, median, etc.

This package provides a framework that joins topic modeling and sentiment analysis of textual data. The package implements a fast Gibbs sampling estimation of Latent Dirichlet Allocation (Griffiths and Steyvers (2004) <doi:10.1073/pnas.0307752101>) and Joint Sentiment/Topic Model (Lin, He, Everson and Ruger (2012) <doi:10.1109/TKDE.2011.48>). It offers a variety of helpers and visualizations to analyze the result of topic modeling. The framework also allows enriching topic models with dates and externally computed sentiment measures. A flexible aggregation scheme enables the creation of time series of sentiment or topical proportions from the enriched topic models. Moreover, a novel method jointly aggregates topic proportions and sentiment measures to derive time series of topical sentiment.

This package provides a comprehensive framework for quantifying the fundamental thermodynamic parameters of adsorption reactionsâ changes in the standard Gibbs free energy (delta G), enthalpy (delta H), and entropy (delta S)â is essential for understanding the spontaneity, heat effects, and molecular ordering associated with sorption processes. By analysing temperature-dependent equilibrium data, thermodynamic interpretation expands adsorption studies beyond conventional isotherm fitting, offering deeper insight into underlying mechanisms and surfaceâ solute interactions. Such an approach typically involves evaluating equilibrium coefficients across multiple temperatures and non-temperature treatments, deriving thermodynamic parameters using established thermodynamic relationships, and determining delta G as a temperature-specific indicator of adsorption favourability. This analytical pathway is widely applicable across environmental science, soil science, chemistry, materials science, and engineering, where reliable assessment of sorption behaviour is critical for examining contaminant retention, nutrient dynamics, and the behaviour of natural and engineered surfaces. By focusing specifically on thermodynamic inference, this framework complements existing adsorption isotherm-fitting packages such as âAdIsMFâ <https://CRAN.R-project.org/package=AdIsMF> <doi:10.32614/CRAN.package.AdIsMF>, and strengthens the scientific basis for interpreting adsorption energetics in both research and applied contexts. Details can be found in Roy et al. (2025) <doi:10.1007/s11270-025-07963-7>.

This package provides a consistent, semi-supervised, non-parametric survival curve estimator optimized for efficient use of Electronic Health Record (EHR) data with a limited number of current status labels. See van der Laan and Robins (1997) <doi:10.2307/2670119>.

This package provides a consistent interface to encrypt and decrypt strings, R objects and files using symmetric and asymmetric key encryption.

User tools for working with The STOICH (Stoichiometric Traits of Organisms in their Chemical Habitats) Project database <https://snr-stoich.unl.edu/>. This package is designed to aid in data discovery, filtering, pairing water samples with organism samples, and merging data tables to assist users in preparing data for analyses. For additional examples see "Additional Examples" and the readme file at <https://github.com/STOICH-project/STOICH-utilities>.

This package implements statistical methods for detecting evolutionary shifts in both the optimal trait value (mean) and evolutionary diffusion variance. The method uses an L1-penalized optimization framework to identify branches where shifts occur, and the shift magnitudes. It also supports the inclusion of measurement error. For more details, see Zhang, Ho, and Kenney (2023) <doi:10.48550/arXiv.2312.17480>.

Generates, plays, and solves Sudoku puzzles. The GUI playSudoku() needs package "tkrplot" if you are not on Windows.

This package implements a three-dimensional stochastic model of cancer growth and mutation similar to the one described in Waclaw et al. (2015) <doi:10.1038/nature14971>. Allows for interactive 3D visualizations of the simulated tumor. Provides a comprehensive summary of the spatial distribution of mutants within the tumor. Contains functions which create synthetic sequencing datasets from the generated tumor.

Implement a promising, and yet little explored protocol for bioacoustical analysis, the eigensound method by MacLeod, Krieger and Jones (2013) <doi:10.4404/hystrix-24.1-6299>. Eigensound is a multidisciplinary method focused on the direct comparison between stereotyped sounds from different species. SoundShape', in turn, provide the tools required for anyone to go from sound waves to Principal Components Analysis, using tools extracted from traditional bioacoustics (i.e. tuneR and seewave packages), geometric morphometrics (i.e. geomorph package) and multivariate analysis (e.g. stats package). For more information, please see Rocha and Romano (2021) and check SoundShape repository on GitHub for news and updates <https://github.com/p-rocha/SoundShape>.

Mixed DNA profiles can be sampled according to models for probabilistic genotyping. Peak height variability is modelled using a log normal distribution or a gamma distribution. Sample contributors may be related according to a pedigree.

This package provides a specialized selection algorithm designed to align simulated fire perimeters with specific fire size distribution scenarios. The foundation of this approach lies in generating a vast collection of plausible simulated fires across a wide range of conditions, assuming a random pattern of ignition. The algorithm then assembles individual fire perimeters based on their specific probabilities of occurrence, e.g., determined by (i) the likelihood of ignition and (ii) the probability of particular fire-weather scenarios, including wind speed and direction. Implements the method presented in Rodrigues (2025a) <doi:10.5194/egusphere-egu25-8974>. Demo data and code examples can be found in Rodrigues (2025b) <doi:10.5281/zenodo.15282605>.

Handling of behavioural data from the Ethoscope platform (Geissmann, Garcia Rodriguez, Beckwith, French, Jamasb and Gilestro (2017) <DOI:10.1371/journal.pbio.2003026>). Ethoscopes (<https://giorgiogilestro.notion.site/Ethoscope-User-Manual-a9739373ae9f4840aa45b277f2f0e3a7>) are an open source/open hardware framework made of interconnected raspberry pis (<https://www.raspberrypi.org>) designed to quantify the behaviour of multiple small animals in a distributed and real-time fashion. The default tracking algorithm records primary variables such as xy coordinates, dimensions and speed. This package is part of the rethomics framework <https://rethomics.github.io/>.

Generates artificial point patterns marked by their spatial and temporal signatures. The resulting point cloud may exhibit inherent interactions between both signatures. The simulation integrates microsimulation (Holm, E., (2017)<doi:10.1002/9781118786352.wbieg0320>) and agent-based models (Bonabeau, E., (2002)<doi:10.1073/pnas.082080899>), beginning with the configuration of movement characteristics for the specified agents (referred to as walkers') and their interactions within the simulation environment. These interactions (Quaglietta, L. and Porto, M., (2019)<doi:10.1186/s40462-019-0154-8>) result in specific spatiotemporal patterns that can be visualized, analyzed, and used for various analytical purposes. Given the growing scarcity of detailed spatiotemporal data across many domains, this package provides an alternative data source for applications in social and life sciences.

Support for reading and writing files in StatDataML---an XML-based data exchange format.

This package provides tools for analyzing and understanding the file contents of large shiny application directories. The package extracts key information about render functions, reactive functions, and their inputs from app files, organizing them into structured data frames for easy reference. This streamlines the onboarding process for new contributors and helps identify areas for optimization in complex shiny codebases with multiple files and sourcing chains.

Collection of conversion, analytical, geodesic, mapping, and plotting functions. Used to support packages and code written by researchers at the Southwest Fisheries Science Center of the National Oceanic and Atmospheric Administration.

Users can build and test customized quantitative trading strategies. Some quantitative trading strategies are already implemented, e.g. various moving-average filters with trend following approaches. The implemented class called "Strategy" allows users to access several methods to analyze performance figures, plots and backtest the strategies. Furthermore, custom strategies can be added, a generic template is available. The custom strategies require a certain input and output so they can be called from the Strategy-constructor.

Local Correlation Integral (LOCI) method for outlier identification is implemented here. The LOCI method developed here is invented in Breunig, et al. (2000), see <doi:10.1145/342009.335388>.

Conducting Bayesian Optimal Interval (BOIN) design for phase I dose-finding trials. simFastBOIN provides functions for pre-computing decision tables, conducting trial simulations, and evaluating operating characteristics. The package uses vectorized operations and the Iso::pava() function for isotonic regression to achieve efficient performance while maintaining full compatibility with BOIN methodology. Version 1.3.2 adds p_saf and p_tox parameters for customizable safety and toxicity thresholds. Version 1.3.1 fixes Date field. Version 1.2.1 adds comprehensive roxygen2 documentation and enhanced print formatting with flexible table output options. Version 1.2.0 integrated C-based PAVA for isotonic regression. Version 1.1.0 introduced conservative MTD selection (boundMTD) and flexible early stopping rules (n_earlystop_rule). Methods are described in Liu and Yuan (2015) <doi:10.1111/rssc.12089>.

This package provides a time series causal inference model for Randomized Controlled Trial (RCT) under spillover effect. SPORTSCausal (Spillover Time Series Causal Inference) separates treatment effect and spillover effect from given responses of experiment group and control group by predicting the response without treatment. It reports both effects by fitting the Bayesian Structural Time Series (BSTS) model based on CausalImpact', as described in Brodersen et al. (2015) <doi:10.1214/14-AOAS788>.