Power estimation and sample size calculation for 10X Visium Spatial Transcriptomics data to detect differential expressed genes between two conditions based on bootstrap resampling. See Shui et al. (2025) <doi:10.1371/journal.pcbi.1013293> for method details.

Fast and Accurate Randomized Singular Value Decomposition (RSVD) methods proposed in the PCAone paper by Li (2023) <https://genome.cshlp.org/content/33/9/1599>.

This package provides tools for extracting and processing structured annotations from R and Python source files to facilitate workflow visualization. The package scans source files for special PUT annotations that define nodes, connections, and metadata within a data processing workflow. These annotations can then be used to generate visual representations of data flows and processing steps across polyglot software environments. Builds on concepts from literate programming Knuth (1984) <doi:10.1093/comjnl/27.2.97> and utilizes directed acyclic graph (DAG) theory for workflow representation Foraita, Spallek, and Zeeb (2014) <doi:10.1007/978-0-387-09834-0_65>. Diagram generation powered by Mermaid Sveidqvist (2014) <https://mermaid.js.org/>.

This package contains the core methods for the evaluation of principal surrogates in a single clinical trial. Provides a flexible interface for defining models for the risk given treatment and the surrogate, the models for integration over the missing counterfactual surrogate responses, and the estimation methods. Estimated maximum likelihood and pseudo-score can be used for estimation, and the bootstrap for inference. A variety of post-estimation summary methods are provided, including print, summary, plot, and testing.

This package implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Classification based analysis of DNA sequences to taxonomic groupings. This package primarily implements Naive Bayesian Classifier from the Ribosomal Database Project. This approach has traditionally been used to classify 16S rRNA gene sequences to bacterial taxonomic outlines; however, it can be used for any type of gene sequence. The method was originally described by Wang, Garrity, Tiedje, and Cole in Applied and Environmental Microbiology 73(16):5261-7 <doi:10.1128/AEM.00062-07>. The package also provides functions to read in FASTA'-formatted sequence data.

Estimates adjusted prevalence ratios (PR) and their confidence intervals from logistic regression models, addressing the well-known limitation of odds ratios (OR) as approximations to PR in cross-sectional studies with common outcomes. Supports independent observations (glm()), clustered/multilevel data (glmer() from lme4'), longitudinal data via Generalised Estimating Equations (geeglm() from geepack'), and complex survey designs (svyglm() from survey'). Inference is available via the delta method (conditional and marginal standardisation) and via bootstrap (normal-approximation and percentile intervals). Continuous covariates are handled through user-specified or median-based reference values; flexible baseline specification allows any reference category to be chosen for factor predictors. Based on the methodology described in Amorim & Ospina (2021) <doi:10.1590/0001-3765202120190316>.

Extracts features from amplification curve data of quantitative Polymerase Chain Reactions (qPCR) according to Pabinger et al. 2014 <doi:10.1016/j.bdq.2014.08.002> for machine learning purposes. Helper functions prepare the amplification curve data for processing as functional data (e.g., Hausdorff distance) or enable the plotting of amplification curve classes (negative, ambiguous, positive). The hookreg() and hookregNL() functions of Burdukiewicz et al. (2018) <doi:10.1016/j.bdq.2018.08.001> can be used to predict amplification curves with an hook effect-like curvature. The pcrfit_single() function can be used to extract features from an amplification curve.

This package provides a simple interface for extracting various elements from the publicly available PubMed XML files, incorporating PubMed's regular updates, and combining the data with the NIH Open Citation Collection. See Schoenbachler and Hughey (2021) <doi:10.7717/peerj.11071>.

Converts TXT and XML data curated by the United States Patent and Trademark Office (USPTO). Allows conversion of bulk data after downloading directly from the USPTO bulk data website, eliminating need for users to wrangle multiple data formats to get large patent databases in tidy, rectangular format. Data details can be found on the USPTO website <https://bulkdata.uspto.gov/>. Currently, all 3 formats: 1. TXT data (1976-2001); 2. XML format 1 data (2002-2004); and 3. XML format 2 data (2005-current) can be converted to rectangular, CSV format. Relevant literature that uses data from USPTO includes Wada (2020) <doi:10.1007/s11192-020-03674-4> and Plaza & Albert (2008) <doi:10.1007/s11192-007-1763-3>.

Deploy, maintain, and invoke predictive models using the Alteryx Promote REST API. Alteryx Promote is available at the URL: <https://www.alteryx.com/products/alteryx-promote>.

Tests periodicity in short time series using response surface regression.

Density, distribution function, quantile function, and random generation function based on Kittipong Klinjan,Tipat Sottiwan and Sirinapa Aryuyuen (2024)<DOI:10.28919/cmbn/8833>.

Create a word cloud using the abstract of publications from Pubmed'.

Computes and compares multiple measures of separation and overlap between phonological categories (for example vowels or consonants) in arbitrary multi-dimensional acoustic spaces such as formant values, mel-frequency cepstral coefficients (MFCCs), duration, or learned embeddings. The main entry point, phontrast(), reports several contrast metrics in one call -- Jensen-Shannon divergence and distance (Lin, 1991) <doi:10.1109/18.61115>, the Pillai-Bartlett trace, Bhattacharyya distance and affinity, Mahalanobis distance, and proportional overlap -- globally or by group on a common separation-oriented scale, with bootstrap confidence intervals. Also provides utilities for preparing estimates for downstream modelling such as generalized additive models and mixed-effects models. Formerly released as phonJSD'.

This package provides some easy-to-use functions for spatial analyses of (plant-) phenological data sets and satellite observations of vegetation.

Generates chronological and ordered p-plots for data vectors or vectors of p-values. The p-plot visualizes the evolution of the p-value of a significance test across the sampled data. It allows for assessing the consistency of the observed effects, for detecting the presence of potential moderator variables, and for estimating the influence of outlier values on the observed results. For non-significant findings, it can diagnose patterns indicative of underpowered study designs. The p-plot can thus either back the binary accept-vs-reject decision of common null-hypothesis significance tests, or it can qualify this decision and stimulate additional empirical work to arrive at more robust and replicable statistical inferences.

Facilitates analysis of paleontological sequences of trait values. Functions are provided to fit, using maximum likelihood, simple evolutionary models (including unbiased random walks, directional evolution,stasis, Ornstein-Uhlenbeck, covariate-tracking) and complex models (punctuation, mode shifts).

This package contains utilities for the analysis of post-translational modifications (PTMs) in proteins, with particular emphasis on the sulfoxidation of methionine residues. Features include the ability to download, filter and analyze data from the sulfoxidation database MetOSite'. Utilities to search and characterize S-aromatic motifs in proteins are also provided. In addition, functions to analyze sequence environments around modifiable residues in proteins can be found. For instance, ptm allows to search for amino acids either overrepresented or avoided around the modifiable residues from the proteins of interest. Functions tailored to test statistical hypothesis related to these differential sequence environments are also implemented. Further and detailed information regarding the methods in this package can be found in (Aledo (2020) <https://metositeptm.com>).

Computes probability-scale residuals and residual correlations for continuous, ordinal, binary, count, and time-to-event data Qi Liu, Bryan Shepherd, Chun Li (2020) <doi:10.18637/jss.v094.i12>.

This package provides functions to estimate the incubation period distribution of post-infectious syndrome which is defined as the time between the symptom onset of the antecedent infection and that of the post-infectious syndrome.

Perform tests for pleiotropy of multiple traits of various variable types on genotypes for a genetic marker.

This package provides a wrapper for Paddle - The Merchant of Record for digital products API (Application Programming Interface) <https://developer.paddle.com/api-reference/overview>. Provides functions to manage and analyze products, customers, invoices and many more.

Manipulates invertible functions from a finite set to itself. Can transform from word form to cycle form and back. To cite the package in publications please use Hankin (2020) "Introducing the permutations R package", SoftwareX, volume 11 <doi:10.1016/j.softx.2020.100453>.