Recently, regularized variable selection has emerged as a powerful tool to identify and dissect gene-environment interactions. Nevertheless, in longitudinal studies with high dimensional genetic factors, regularization methods for GÃ E interactions have not been systematically developed. In this package, we provide the implementation of sparse group variable selection, based on both the quadratic inference function (QIF) and generalized estimating equation (GEE), to accommodate the bi-level selection for longitudinal GÃ E studies with high dimensional genomic features. Alternative methods conducting only the group or individual level selection have also been included. The core modules of the package have been developed in C++.

Spatial transcriptomics iterative hierarchical clustering ('stIHC'), is a method for identifying spatial gene co-expression modules, defined as groups of genes with shared spatial expression patterns. The method is applicable across spatial transcriptomics technologies with differing spatial resolution, and provides a framework for investigating the spatial organisation of gene expression in tissues. For further details, see Higgins C., Li J.J., Carey M. <doi:10.1002/qub2.70011>.

This package provides tools for Bayesian learning of spatiotemporal dynamical mechanistic models. Includes methods for parameter estimation, simulation, and inference using hierarchical and state-space modeling approaches, following Banerjee, Chen, Frankenburg and Zhou (2025) <https://jmlr.org/papers/v26/22-0896.html>.

An extensible framework for developing species distribution models using individual and community-based approaches, generate ensembles of models, evaluate the models, and predict species potential distributions in space and time. For more information, please check the following paper: Naimi, B., Araujo, M.B. (2016) <doi:10.1111/ecog.01881>.

Terrestrial and marine predictors for species distribution modelling from multiple sources, including WorldClim <https://www.worldclim.org/>,, ENVIREM <https://envirem.github.io/>, Bio-ORACLE <https://bio-oracle.org/> and MARSPEC <http://www.marspec.org/>.

Implement the algorithm provided in scan for estimating the transmission route on railway network using passenger volume. It is a generalization of the scan statistic approach for railway network to identify the hot railway route for transmitting infectious diseases.

Aims to quantify time intensity data by using sigmoidal and double sigmoidal curves. It fits straight lines, sigmoidal, and double sigmoidal curves on to time vs intensity data. Then all the fits are used to make decision on which model best describes the data. This method was first developed in the context of single-cell viral growth analysis (for details, see Caglar et al. (2018) <doi:10.7717/peerj.4251>), and the package name stands for "SIngle CEll Growth Analysis in R".

It fits scale mixture of skew-normal linear mixed models using either an expectationâ maximization (EM) type algorithm or its accelerated version (Damped Anderson Acceleration with Epsilon Monotonicity, DAAREM), including some possibilities for modeling the within-subject dependence <doi:10.18637/jss.v115.i07>.

Fit a spatial-temporal occupancy models using a probit formulation instead of a traditional logit model.

Companion package that supports the surveydown survey platform (<https://surveydown.org>). The default method for working with a surveydown survey is to edit the plain text survey.qmd and app.R files. With sdstudio', you can create, preview and manage surveys with a shiny application as a graphical user interface.

This package provides a supervised compression method that incorporates the response for reducing big data to a carefully selected subset. Please see Joseph and Mak (2021) <doi:10.1002/sam.11508>. This research is supported by a U.S. National Science Foundation (NSF) grant CMMI-1921646.

An Object-oriented Framework for Geostatistical Modeling in S+ containing functions for variogram estimation, variogram fitting and kriging as well as some plot functions. Written entirely in S, therefore works only for small data sets in acceptable computing time.

Estimates incidence rate ratios by comparing time exposed with time unexposed among an exposed cohort using self-controlled cohort methodology as described in Ryan et al. (2013) <doi:10.1002/pds.3457>. Functions used for empirical calibration of effect estimates, confidence intervals, and p-values are included to control for residual bias.

Assesses the number of concurrent users shiny applications are capable of supporting, and for directing application changes in order to support a higher number of users. Provides facilities for recording shiny application sessions, playing recorded sessions against a target server at load, and analyzing the resulting metrics.

Transform a Movie into a Synthetic Picture. A frame every 10 seconds is summarized into one colour, then every generated colors are stacked together.

This package provides functions for computing a standardized moderation effect in moderated regression and forming its confidence interval by nonparametric bootstrapping as proposed in Cheung, Cheung, Lau, Hui, and Vong (2022) <doi:10.1037/hea0001188>. Also includes simple-to-use functions for computing conditional effects (unstandardized or standardized) and plotting moderation effects.

This package provides tools for making, retrieving, displaying and solving sudoku games. This package is an alternative to the earlier sudoku-solver package, sudoku'. The present package uses a slightly different algorithm, has a simpler coding and presents a few more sugar tools, such as plot and print methods. Solved sudoku games are of some interest in Experimental Design as examples of Latin Square designs with additional balance constraints.

This package provides a Shiny app including the Monaco editor. The Monaco editor is the code editor which powers VS Code'. It is particularly well developed for JavaScript'. In addition to the Monaco editor features, the app provides prettifiers and minifiers for multiple languages, SCSS and TypeScript compilers, code checking for C and C++ (requires cppcheck').

This package provides deep learning models for right-censored survival data using the torch backend. Supports multiple loss functions, including Cox partial likelihood, L2-penalized Cox, time-dependent Cox, and accelerated failure time (AFT) loss. Offers a formula-based interface, built-in support for cross-validation, hyperparameter tuning, survival curve plotting, and evaluation metrics such as the C-index, Brier score, and integrated Brier score. For methodological details, see Kvamme et al. (2019) <https://www.jmlr.org/papers/v20/18-424.html>. The package is described in El Badisy (2026) <doi:10.32614/RJ-2026-008>.

This package provides a simple tool for numerical optimization on the unit sphere. This is achieved by combining the spherical coordinating system with L-BFGS-B optimization. This algorithm is implemented in Kolkiewicz, A., Rice, G., & Xie, Y. (2020) <doi:10.1016/j.jspi.2020.07.001>.

It contains soft clustering algorithms, in particular approaches derived from rough set theory: Lingras & West original rough k-means, Peters refined rough k-means, and PI rough k-means. It also contains classic k-means and a corresponding illustrative demo.

Efficient containers for storing and managing prediction outputs from survival models, including Cox proportional hazards, random survival forests, and modern machine learning estimators. Provides fast C++ methods to evaluate survival probabilities, hazards, probability densities, and related quantities at arbitrary time points, with support for multiple interpolation methods via Rcpp'.

SCEPtER pipeline for estimating the stellar age for double-lined detached binary systems. The observational constraints adopted in the recovery are the effective temperature, the metallicity [Fe/H], the mass, and the radius of the two stars. The results are obtained adopting a maximum likelihood technique over a grid of pre-computed stellar models.

Download data (tables and datasets) from the Swiss National Bank (SNB; <https://www.snb.ch/en>), the Swiss central bank. The package is lightweight and comes with few dependencies; suggested packages are used only if data is to be transformed into particular data structures, for instance into zoo objects. Downloaded data can optionally be cached, to avoid repeated downloads of the same files.