The correlations and linkage disequilibrium between tests can vary as a function of minor allele frequency thresholds used to filter variants, and also varies with different choices of test statistic for region-based tests. Appropriate genome-wide significance thresholds can be estimated empirically through permutation on only a small proportion of the whole genome.

This package provides tools to download comprehensive datasets of local, state, and federal election results in Germany from 1990 to 2025. The package facilitates access to data on turnout, vote shares for major parties, and demographic information across different levels of government (municipal, state, and federal). It offers access to geographically harmonized datasets that account for changes in municipal boundaries over time and incorporate mail-in voting districts. Users can easily retrieve, clean, and standardize German electoral data, making it ready for analysis. Data is sourced from <https://github.com/awiedem/german_election_data>.

Seamless integration between R and Goose AI capabilities including memory management, visualization enhancements, and workflow automation. Save R objects to Goose memory, apply Block branding to visualizations, and manage data science project workflows. For more information about Goose AI, see <https://github.com/block/goose>.

Build display tables from tabular data with an easy-to-use set of functions. With its progressive approach, we can construct display tables with a cohesive set of table parts. Table values can be formatted using any of the included formatting functions. Footnotes and cell styles can be precisely added through a location targeting system. The way in which gt handles things for you means that you don't often have to worry about the fine details.

This package provides a convenient R interface to the Genotype-Tissue Expression (GTEx) Portal API. The GTEx project is a comprehensive public resource for studying tissue-specific gene expression and regulation in human tissues. Through systematic analysis of RNA sequencing data from 54 non-diseased tissue sites across nearly 1000 individuals, GTEx provides crucial insights into the relationship between genetic variation and gene expression. This data is accessible through the GTEx Portal API enabling programmatic access to human gene expression data. For more information on the API, see <https://gtexportal.org/api/v2/redoc>.

Helper to add insets based on geom_sf() from ggplot2'. This package gives you a drop-in replacement for geom_sf() that supports adding a zoomed inset map without having to create and embed a separate plot.

Second-order summary statistics K- and pair-correlation functions describe interactions in point pattern data. This package provides computations to estimate those statistics on inhomogeneous point processes, using the methods of in T Shaw, J Møller, R Waagepetersen, 2020 <doi:10.48550/arXiv.2004.00527>.

Maximum likelihood estimation, random values generation, density computation and other functions for the exponential-Poisson generalised exponential-Poisson and Poisson-exponential distributions. References include: Rodrigues G. C., Louzada F. and Ramos P. L. (2018). "Poisson-exponential distribution: different methods of estimation". Journal of Applied Statistics, 45(1): 128--144. <doi:10.1080/02664763.2016.1268571>. Louzada F., Ramos, P. L. and Ferreira, H. P. (2020). "Exponential-Poisson distribution: estimation and applications to rainfall and aircraft data with zero occurrence". Communications in Statistics--Simulation and Computation, 49(4): 1024--1043. <doi:10.1080/03610918.2018.1491988>. Barreto-Souza W. and Cribari-Neto F. (2009). "A generalization of the exponential-Poisson distribution". Statistics and Probability Letters, 79(24): 2493--2500. <doi:10.1016/j.spl.2009.09.003>.

This package provides functions to develop simulated continuous data (e.g., gene expression) from a sigma covariance matrix derived from a graph structure in igraph objects. Intended to extend mvtnorm to take igraph structures rather than sigma matrices as input. This allows the use of simulated data that correctly accounts for pathway relationships and correlations. This allows the use of simulated data that correctly accounts for pathway relationships and correlations. Here we present a versatile statistical framework to simulate correlated gene expression data from biological pathways, by sampling from a multivariate normal distribution derived from a graph structure. This package allows the simulation of biological pathways from a graph structure based on a statistical model of gene expression. For example methods to infer biological pathways and gene regulatory networks from gene expression data can be tested on simulated datasets using this framework. This also allows for pathway structures to be considered as a confounding variable when simulating gene expression data to test the performance of genomic analyses.

This package implements the Rank In Similarity Graph Edge-count two-sample test (RISE) for high-dimensional and non-Euclidean data. The method constructs similarity-based graphs, such as k-nearest neighbor graph (k-NNG), k-minimum spanning tree (k-MST), and k-minimum distance non-bipartite pairing (k-MDP), and evaluates rank-based within-sample edge counts with asymptotic and permutation p-values. For methodological details, see Zhou and Chen (2023) <https://proceedings.mlr.press/v195/zhou23a.html>.

Works with ggplot2 to add a Van Gogh color palette to the userâ s repertoire. It also has a function that work alongside ggplot2 to create more interesting data visualizations and add contextual information to the userâ s plots.

Discretize multivariate continuous data using a grid to capture the joint distribution that preserves clusters in original data. It can handle both labeled or unlabeled data. Both published methods (Wang et al 2020) <doi:10.1145/3388440.3412415> and new methods are included. Joint grid discretization can prepare data for model-free inference of association, function, or causality.

Performing goodness-of-fit tests for stochastic block models used to fit network data. Among the three variants discussed in Karwa et al. (2023) <doi:10.1093/jrsssb/qkad084>, goodness-of-fit test has been performed for the Erdos-Renyi (ER) and Beta versions.

This package provides interactive visualisations for exploratory data analysis of high-dimensional datasets. Includes parallel coordinate plots for exploring large datasets with mostly quantitative features, but also stacked one-dimensional visualisations that more effectively show missingness and complex categorical relationships in smaller datasets.

You can use this function to easily draw a combined histogram and restricted cubic spline. The function draws the graph through ggplot2'. RCS fitting requires the use of the rcs() function of the rms package. Can fit cox regression, logistic regression. This method was described by Per Kragh (2003) <doi:10.1002/sim.1497>.

This package provides a model building procedure to build parsimonious geoadditive model from a large number of covariates. Continuous, binary and ordered categorical responses are supported. The model building is based on component wise gradient boosting with linear effects, smoothing splines and a smooth spatial surface to model spatial autocorrelation. The resulting covariate set after gradient boosting is further reduced through backward elimination and aggregation of factor levels. The package provides a model based bootstrap method to simulate prediction intervals for point predictions. A test data set of a soil mapping case study in Berne (Switzerland) is provided. Nussbaum, M., Walthert, L., Fraefel, M., Greiner, L., and Papritz, A. (2017) <doi:10.5194/soil-3-191-2017>.

Estimates statistically significant marker combination values within which one immunologically distinctive group (i.e., disease case) is more associated than another group (i.e., healthy control), successively, using various combinations (i.e., "gates") of markers to examine features of cells that may be different between groups. For a two-group comparison, the gateR package uses the spatial relative risk function estimated using the sparr package. Details about the sparr package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.

Estimates a counterfactual using Gaussian process projection. It takes a dataframe, creates missingness in the desired outcome variable and estimates counterfactual values based on all information in the dataframe. The package writes Stan code, checks it for convergence and adds artificial noise to prevent overfitting and returns a plot of actual values and estimated counterfactual values using r-base plot.

This package provides methods for processing spatial data for decision-making. This package is an R implementation of methods provided by the open source software GeoFIS <https://www.geofis.org> (Leroux et al. 2018) <doi:10.3390/agriculture8060073>. The main functionalities are the management zone delineation (Pedroso et al. 2010) <doi:10.1016/j.compag.2009.10.007> and data aggregation (Mora-Herrera et al. 2020) <doi:10.1016/j.compag.2020.105624>.

This package provides a statistical hypothesis test for conditional independence. Given residuals from a sufficiently powerful regression, it tests whether the covariance of the residuals is vanishing. It can be applied to both discretely-observed functional data and multivariate data. Details of the method can be found in Anton Rask Lundborg, Rajen D. Shah and Jonas Peters (2022) <doi:10.1111/rssb.12544>.

This package provides functions to compute generalized eigenvalues and eigenvectors, the generalized Schur decomposition and the generalized Singular Value Decomposition of a matrix pair, using Lapack routines.

R-interface to C++ implementation of the rank/score permutation based GSEA test (Subramanian et al 2005 <doi: 10.1073/pnas.0506580102>).

This package provides functions for Gaussian and Non Gaussian (bivariate) spatial and spatio-temporal data analysis are provided for a) (fast) simulation of random fields, b) inference for random fields using standard likelihood and a likelihood approximation method called weighted composite likelihood based on pairs and b) prediction using (local) best linear unbiased prediction. Weighted composite likelihood can be very efficient for estimating massive datasets. Both regression and spatial (temporal) dependence analysis can be jointly performed. Flexible covariance models for spatial and spatial-temporal data on Euclidean domains and spheres are provided. There are also many useful functions for plotting and performing diagnostic analysis. Different non Gaussian random fields can be considered in the analysis. Among them, random fields with marginal distributions such as Skew-Gaussian, Student-t, Tukey-h, Sin-Arcsin, Two-piece, Weibull, Gamma, Log-Gaussian, Binomial, Negative Binomial and Poisson. See the URL for the papers associated with this package, as for instance, Bevilacqua and Gaetan (2015) <doi:10.1007/s11222-014-9460-6>, Bevilacqua et al. (2016) <doi:10.1007/s13253-016-0256-3>, Vallejos et al. (2020) <doi:10.1007/978-3-030-56681-4>, Bevilacqua et. al (2020) <doi:10.1002/env.2632>, Bevilacqua et. al (2021) <doi:10.1111/sjos.12447>, Bevilacqua et al. (2022) <doi:10.1016/j.jmva.2022.104949>, Morales-Navarrete et al. (2023) <doi:10.1080/01621459.2022.2140053>, and a large class of examples and tutorials.

This package provides functions for survey data including svydesign objects from the survey package that call ggplot2 to make bar charts, histograms, boxplots, and hexplots of survey data.