Herramientas para el análisis de datos de COVID-19 en México. Descarga y analiza los datos para COVID-19 de la Direccion General de Epidemiologà a de México (DGE) <https://www.gob.mx/salud/documentos/datos-abiertos-152127>, la Red de Infecciones Respiratorias Agudas Graves (Red IRAG) <https://www.gits.igg.unam.mx/red-irag-dashboard/reviewHome> y la Iniciativa Global para compartir todos los datos de influenza (GISAID) <https://gisaid.org/>. English: Downloads and analyzes data of COVID-19 from the Mexican General Directorate of Epidemiology (DGE), the Network of Severe Acute Respiratory Infections (IRAG network),and the Global Initiative on Sharing All Influenza Data GISAID.

This package provides a collection of cardiovascular research datasets and analytical tools, including methods for cardiovascular procedural data, such as electrocardiography, echocardiography, and catheterization data. Additional methods exist for analysis of procedural billing codes.

Tool for performing computational testing for conditional independence between variables in a dataset. CCI implements permutation in combination with Monte Carlo Cross-Validation in generating null distributions and test statistics. For more details see Computational Test for Conditional Independence (2024) <doi:10.3390/a17080323>.

Accuracy metrics are commonly used to assess the discriminating ability of diagnostic tests or biomarkers. Among them, metrics based on the ROC framework are particularly popular. When classification involves subclasses, the package CompClassMetrics includes functions that can provide the point estimate, confidence interval as well as true values if a parametric setting is known. For more details see Nan and Tian (2025) <doi:10.1177/09622802251343600> and Nan and Tian (2023) <doi:10.1002/sim.9908> and Feng and Tian (2020) <doi:10.1177/0962280220938077>.

Given a non-linear model, calculate the local explanation. We purpose view the data space, explanation space, and model residuals as ensemble graphic interactive on a shiny application. After an observation of interest is identified, the normalized variable importance of the local explanation is used as a 1D projection basis. The support of the local explanation is then explored by changing the basis with the use of the radial tour <doi:10.32614/RJ-2020-027>; <doi:10.1080/10618600.1997.10474754>.

Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

Regression splines that handle a mix of continuous and categorical (discrete) data often encountered in applied settings. I would like to gratefully acknowledge support from the Natural Sciences and Engineering Research Council of Canada (NSERC, <https://www.nserc-crsng.gc.ca>), the Social Sciences and Humanities Research Council of Canada (SSHRC, <https://www.sshrc-crsh.gc.ca>), and the Shared Hierarchical Academic Research Computing Network (SHARCNET, <https://www.sharcnet.ca>). We would also like to acknowledge the contributions of the GNU GSL authors. In particular, we adapt the GNU GSL B-spline routine gsl_bspline.c adding automated support for quantile knots (in addition to uniform knots), providing missing functionality for derivatives, and for extending the splines beyond their endpoints.

Markov chain Monte Carlo based inference routines for collapsed latent position cluster models or social networks, which includes searches over the model space (number of clusters in the latent position cluster model). The label switching algorithm used is that of Nobile and Fearnside (2007) <doi:10.1007/s11222-006-9014-7> which relies on the algorithm of Carpaneto and Toth (1980) <doi:10.1145/355873.355883>.

Find multiple solutions of a nonlinear least squares problem. Cluster Gauss-Newton method does not assume uniqueness of the solution of the nonlinear least squares problem and compute multiple minimizers. Please cite the following paper when this software is used in your research: Aoki et al. (2020) <doi:10.1007/s11081-020-09571-2>. Cluster Gaussâ Newton method. Optimization and Engineering, 1-31. Please cite the following paper when profile likelihood plot is drawn with this software and used in your research: Aoki and Sugiyama (2024) <doi:10.1002/psp4.13055>. Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models. CPT Pharmacometrics Syst Pharmacol.13(1):54-67. GPT based helper bot available at <https://chatgpt.com/g/g-684936db9e748191a2796debb00cd755-cluster-gauss-newton-method-helper-bot> .

Provided data containing an outcome variable, compositional variables and additional covariates (optional); linearly regress the outcome variable on an isometric log ratio (ilr) transformation of the linearly dependent compositional variables. The package provides predictions (with confidence intervals) in the change (delta) in the outcome/response variable based on the multiple linear regression model and evenly spaced reallocations of the compositional values. The compositional data analysis approach implemented is outlined in Dumuid et al. (2017a) <doi:10.1177/0962280217710835> and Dumuid et al. (2017b) <doi:10.1177/0962280217737805>.

Dataset containing cumulative COVID-19 deaths (absolute and per 100,000 pop) at the regional level (mostly NUTS 3) for 31 EU/EFTA countries.

This package provides a collection of utilities for the statistical analysis of multivariate circular data using distributions based on Multivariate Nonnegative Trigonometric Sums (MNNTS). The package includes functions for calculation of densities and distributions, for the estimation of parameters, and more.

Perform additional multiple testing procedure methods to p.adjust(), such as weighted Hochberg (Tamhane, A. C., & Liu, L., 2008) <doi:10.1093/biomet/asn018>, ICC adjusted Bonferroni method (Shi, Q., Pavey, E. S., & Carter, R. E., 2012) <doi:10.1002/pst.1514> and a new correlation corrected weighted Hochberg for correlated endpoints.

Fits a variety of cure models using excess hazard modeling methodology such as the mixture model proposed by Phillips et al. (2002) <doi:10.1002/sim.1101> The Weibull distribution is used to represent the survival function of the uncured patients; Fits also non-mixture cure model such as the time-to-null excess hazard model proposed by Boussari et al. (2020) <doi:10.1111/biom.13361>.

Clustering, or cluster analysis, is a widely used technique in bioinformatics to identify groups of similar biological data points. Consensus clustering is an extension to clustering algorithms that aims to construct a robust result from those clustering features that are invariant under different sources of variation. For the reference, please cite the following paper: Yousefi, Melograna, et. al., (2023) <doi:10.3389/fmicb.2023.1170391>.

Evaluates stimuli using Large Language Models APIs with URL support.

Develop Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. The Pharmacometric Modeling Language (PML) code updates in real time given changes to user inputs. Models can be executed using the Certara.RsNLME package. Additional support to generate the underlying Certara.RsNLME code to recreate the corresponding model in R is provided in the user interface.

Cox model inference for relative hazard and covariate-specific pure risk estimated from stratified and unstratified case-cohort data as described in Etievant, L., Gail, M.H. (Lifetime Data Analysis, 2024) <doi:10.1007/s10985-024-09621-2>.

Utility functions that provides wrapper to descriptive base functions like cor, mean and table. It makes use of the formula interface to pass variables to functions. It also provides operators to concatenate (%+%), to repeat (%n%) and manage character vectors for nice display.

Conditional graphical lasso estimator is an extension of the graphical lasso proposed to estimate the conditional dependence structure of a set of p response variables given q predictors. This package provides suitable extensions developed to study datasets with censored and/or missing values. Standard conditional graphical lasso is available as a special case. Furthermore, the package provides an integrated set of core routines for visualization, analysis, and simulation of datasets with censored and/or missing values drawn from a Gaussian graphical model. Details about the implemented models can be found in Augugliaro et al. (2023) <doi: 10.18637/jss.v105.i01>, Augugliaro et al. (2020b) <doi: 10.1007/s11222-020-09945-7>, Augugliaro et al. (2020a) <doi: 10.1093/biostatistics/kxy043>, Yin et al. (2001) <doi: 10.1214/11-AOAS494> and Stadler et al. (2012) <doi: 10.1007/s11222-010-9219-7>.

Software which provides numerous functionalities for detecting and removing group-level effects from high-dimensional scientific data which, when combined with additional assumptions, allow for causal conclusions, as-described in our manuscripts Bridgeford et al. (2024) <doi:10.1101/2021.09.03.458920> and Bridgeford et al. (2023) <doi:10.48550/arXiv.2307.13868>. Also provides a number of useful utilities for generating simulations and balancing covariates across multiple groups/batches of data via matching and propensity trimming for more than two groups.

We propose a method to estimate the probability of an undetected case of COVID-19 in a defined setting, when a given number of people have been exposed, with a given pretest probability of having COVID-19 as a result of that exposure. Since we are interested in undetected COVID-19, we assume no person has developed symptoms (which would warrant further investigation) and that everyone was tested on a given day, and all tested negative.

This package implements Markowitz Critical Line Algorithm ('CLA') for classical mean-variance portfolio optimization, see Markowitz (1952) <doi:10.2307/2975974>. Care has been taken for correctness in light of previous buggy implementations.

This package provides a versatile R package for creating and pricing custom derivatives to suit your financial needs.