This package provides a S3 resource is provided by Amazon Web Services S3 or a S3-compatible object store (such as Minio). The resource can be a tidy file to be downloaded from the object store, or a data lake (such as Delta Lake) Parquet file to be read by Apache Spark.

Enables the creation of Chain Event Graphs over spatial areas, with an optional Shiny user interface. Allows users to fully customise both the structure and underlying model of the Chain Event Graph, offering a high degree of flexibility for tailored analyses. For more details on Chain Event Graphs, see Freeman, G., & Smith, J. Q. (2011) <doi:10.1016/j.jmva.2011.03.008>, Collazo R. A., Görgen C. and Smith J. Q. (2018, ISBN:9781498729604) and Barclay, L. M., Hutton, J. L., & Smith, J. Q. (2014) <doi:10.1214/13-BA843>.

Monitoring reporting rates of subject-level clinical events (e.g. adverse events, protocol deviations) reported by clinical trial sites is an important aspect of risk-based quality monitoring strategy. Sites that are under-reporting or over-reporting events can be detected using bootstrap simulations during which patients are redistributed between sites. Site-specific distributions of event reporting rates are generated that are used to assign probabilities to the observed reporting rates. (Koneswarakantha 2024 <doi:10.1007/s43441-024-00631-8>).

Health research using data from electronic health records (EHR) has gained popularity, but misclassification of EHR-derived disease status and lack of representativeness of the study sample can result in substantial bias in effect estimates and can impact power and type I error for association tests. Here, the assumed target of inference is the relationship between binary disease status and predictors modeled using a logistic regression model. SAMBA implements several methods for obtaining bias-corrected point estimates along with valid standard errors as proposed in Beesley and Mukherjee (2020) <doi:10.1111/biom.13400>, Biometrics.

This package provides functions to test for a treatment effect in terms of the difference in survival between a treatment group and a control group using surrogate marker information obtained at some early time point in a time-to-event outcome setting. Nonparametric kernel estimation is used to estimate the test statistic and perturbation resampling is used for variance estimation. More details will be available in the future in: Parast L, Cai T, Tian L (2019) ``Using a Surrogate Marker for Early Testing of a Treatment Effect" Biometrics, 75(4):1253-1263. <doi:10.1111/biom.13067>.

Surface Protein abundance Estimation using CKmeans-based clustered thresholding ('SPECK') is an unsupervised learning-based method that performs receptor abundance estimation for single cell RNA-sequencing data based on reduced rank reconstruction (RRR) and a clustered thresholding mechanism. Seurat's normalization method is described in: Hao et al., (2021) <doi:10.1016/j.cell.2021.04.048>, Stuart et al., (2019) <doi:10.1016/j.cell.2019.05.031>, Butler et al., (2018) <doi:10.1038/nbt.4096> and Satija et al., (2015) <doi:10.1038/nbt.3192>. Method for the RRR is further detailed in: Erichson et al., (2019) <doi:10.18637/jss.v089.i11> and Halko et al., (2009) <doi:10.48550/arXiv.0909.4061>. Clustering method is outlined in: Song et al., (2020) <doi:10.1093/bioinformatics/btaa613> and Wang et al., (2011) <doi:10.32614/RJ-2011-015>.

This package implements sparse Bayesian learning method for QTL mapping and genome-wide association studies.

Build EQUATOR-style flowcharts for clinical studies by sequentially defining inclusion and exclusion criteria, study arms, and endpoints. The pipe-friendly API supports CONSORT (randomized trials), STROBE (observational cohorts), STARD (diagnostic accuracy), PRISMA (systematic reviews), and MOOSE (observational meta-analysis) diagram layouts, as well as multi-source convergence, split-and-recombine, factorial, and hybrid topologies. Diagrams are rendered via grid graphics in both data-driven (automatic counting) and manual-count modes, with optional DiagrammeR'/'Graphviz output.

Pauly et al. (2008) <http://legacy.seaaroundus.s3.amazonaws.com/doc/Researcher+Publications/dpauly/PDF/2008/Books%26Chapters/FisheriesInLargeMarineEcosystems.pdf> created (and coined the name) Stock Status Plots for a UNEP compendium on Large Marine Ecosystems(LMEs, Sherman and Hempel (2009)<https://marineinfo.org/imis?module=ref&refid=142061&printversion=1&dropIMIStitle=1>). Stock status plots are bivariate graphs summarizing the status (e.g., developing, fully exploited, overexploited, etc.), through time, of the multispecies fisheries of a fished area or ecosystem. This package contains three functions to generate stock status plots viz., SSplots_pauly() (as per the criteria proposed by Pauly et al.,2008), SSplots_kleisner() (as per the criteria proposed by Kleisner and Pauly (2011) <http://www.ecomarres.com/downloads/regional.pdf> and Kleisner et al. (2013) <doi:10.1111/j.1467-2979.2012.00469.x>)and SSplots_EPI() (as per the criteria proposed by Jayasankar et al.,2021 <https://eprints.cmfri.org.in/11364/>).

This package provides a system enables cross study Analysis by extracting and filtering study data for control animals from CDISC SEND Study Repository. These data types are supported: Body Weights, Laboratory test results and Microscopic findings. These database types are supported: SQLite and Oracle'.

This package implements estimation methods for shrinkage covariance matrices using user-specified covariance targets. The covariance target is a structured matrix towards which the unbiased sample covariance is shrunk, optionally incorporating prior knowledge. Shrinkage intensity is computed analytically. The method is described and applied to microarray gene expression data in Jelizarow et al. (2010) <doi:10.1093/bioinformatics/btq323>.

Maximum likelihood estimation for stochastic frontier analysis (SFA) of production (profit) and cost functions. The package includes the basic stochastic frontier for cross-sectional or pooled data with several distributions for the one-sided error term (i.e., Rayleigh, gamma, Weibull, lognormal, uniform, generalized exponential and truncated skewed Laplace), the latent class stochastic frontier model (LCM) as described in Dakpo et al. (2021) <doi:10.1111/1477-9552.12422>, for cross-sectional and pooled data, and the sample selection model as described in Greene (2010) <doi:10.1007/s11123-009-0159-1>, and applied in Dakpo et al. (2021) <doi:10.1111/agec.12683>. Several possibilities in terms of optimization algorithms are proposed.

Determine sample sizes, draw samples, and conduct data analysis using data frames. It specifically enables you to determine simple random sample sizes, stratified sample sizes, and complex stratified sample sizes using a secondary variable such as population; draw simple random samples and stratified random samples from sampling data frames; determine which observations are missing from a random sample, missing by strata, duplicated within a dataset; and perform data analysis, including proportions, margins of error and upper and lower bounds for simple, stratified and cluster sample designs.

The purpose of this package is to manipulate SVG files that are templates of charts the user wants to produce. In vector graphics one copes with x-/y-coordinates of elements (e.g. lines, rectangles, text). Their scale is often dependent on the program that is used to produce the graphics. In applied statistics one usually has numeric values on a fixed scale (e.g. percentage values between 0 and 100) to show in a chart. Basically, svgtools transforms the statistical values into coordinates and widths/heights of the vector graphics. This is done by stackedBar() for bar charts, by linesSymbols() for charts with lines and/or symbols (dot markers) and scatterSymbols() for scatterplots.

This package provides a wrapper for Blizzard's Starcraft II (a 2010 real-time strategy game) Application Programming Interface (API). All documented API calls are implemented in an easy-to-use and consistent manner.

Calculate the statistical power to detect clusters using kernel-based spatial relative risk functions that are estimated using the sparr package. Details about the sparr package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.

Flexible stochastic tree ensemble software. Robust implementations of Bayesian Additive Regression Trees (BART) (Chipman, George, McCulloch (2010) <doi:10.1214/09-AOAS285>) for supervised learning and Bayesian Causal Forests (BCF) (Hahn, Murray, Carvalho (2020) <doi:10.1214/19-BA1195>) for causal inference. Enables model serialization and parallel sampling and provides a low-level interface for custom stochastic forest samplers. Includes the grow-from-root algorithm for accelerated forest sampling (He and Hahn (2021) <doi:10.1080/01621459.2021.1942012>), a log-linear leaf model for forest-based heteroskedasticity (Murray (2020) <doi:10.1080/01621459.2020.1813587>), and the cloglog BART model of Alam and Linero (2025) <doi:10.48550/arXiv.2502.00606> for ordinal outcomes.

This package provides a toolkit for stratified medicine, subgroup identification, and precision medicine. Current tools include (1) filtering models (reduce covariate space), (2) patient-level estimate models (counterfactual patient-level quantities, such as the conditional average treatment effect), (3) subgroup identification models (find subsets of patients with similar treatment effects), and (4) treatment effect estimation and inference (for the overall population and discovered subgroups). These tools can be customized and are directly used in PRISM (patient response identifiers for stratified medicine; Jemielita and Mehrotra 2019 <doi:10.48550/arXiv.1912.03337>).

This package provides a set of methods to implement Generalized Method of Moments and Maximal Likelihood methods for Random Utility Models. These methods are meant to provide inference on rank comparison data. These methods accept full, partial, and pairwise rankings, and provides methods to break down full or partial rankings into their pairwise components. Please see Generalized Method-of-Moments for Rank Aggregation from NIPS 2013 for a description of some of our methods.

Track and record the use of applications and the user's interactions with Shiny inputs. Allows to trace the inputs with which the user interacts, the outputs generated, as well as the errors displayed in the interface.

You can use the functions provided by the package to make various statistical tables, such as baseline data tables. Creates Table 1', i.e., a description of the baseline patient characteristics, which is essential in every medical research. Supports both continuous and categorical variables, as well as p-values and standardized mean differences. This method was described by Mary L McHugh (2013) <doi:10.11613/bm.2013.018>.

This package provides ggplot2 graphics for analysing time series data. It aims to fit into the tidyverse and grammar of graphics framework for handling temporal data.

Add fancy CSS effects to your shinydashboards or shiny apps. 100% compatible with shinydashboardPlus and bs4Dash'.

Assesses the number of concurrent users shiny applications are capable of supporting, and for directing application changes in order to support a higher number of users. Provides facilities for recording shiny application sessions, playing recorded sessions against a target server at load, and analyzing the resulting metrics.