This package creates an object that stores a matrix ensemble, matrices that share the same common properties, where rows and columns can be annotated. Matrices must have the same dimension and dimnames. Operators to manipulate these objects are provided as well as mechanisms to apply functions to these objects.

This grants the functionality of the Maxar Geospatial Platform (MGP) Streaming API. It can search for images using the WFS method. It can Download images using WMS WMTS. It can also Download a full resolution image.

Build CPMs (cumulative probability models, also known as cumulative link models) to account for detection limits (both single and multiple detection limits) in response variables. Conditional quantiles and conditional CDFs can be calculated based on fitted models. The package implements methods described in Tian, Y., Li, C., Tu, S., James, N. T., Harrell, F. E., & Shepherd, B. E. (2022). "Addressing Detection Limits with Semiparametric Cumulative Probability Models". <arXiv:2207.02815>.

Tabulate and plot directional and other multivariate histograms.

This package provides a novel mediation analysis approach to address zero-inflated mediators containing true zeros and false zeros. See Jiang et al (2023) "A Novel Causal Mediation Analysis Approach for Zero-Inflated Mediators" <arXiv:2301.10064> for more details.

This package provides essential tools for the pre-processing techniques of matching and weighting multiply imputed datasets. The package includes functions for matching within and across multiply imputed datasets using various methods, estimating weights for units in the imputed datasets using multiple weighting methods, calculating causal effect estimates in each matched or weighted dataset using parametric or non-parametric statistical models, and pooling the resulting estimates according to Rubin's rules (please see <https://journal.r-project.org/archive/2021/RJ-2021-073/> for more details).

This GUI for the mi package walks the user through the steps of multiple imputation and the analysis of completed data.

This package provides methods for modeling moderator variables in cross-sectional, temporal, and multi-level networks. Includes model selection techniques and a variety of plotting functions. Implements the methods described by Swanson (2020) <https://www.proquest.com/openview/d151ab6b93ad47e3f0d5e59d7b6fd3d3>.

Integrates large language model generated item responses into psychometric calibration studies through a mixed-subjects design for unidimensional two-parameter and one-parameter logistic item response theory models. Human pilot responses are augmented with model-generated responses using a prediction-powered inference estimator (Angelopoulos, Bates, Fannjiang, Jordan and Zrnic (2023) <doi:10.1126/science.adi6000>; Angelopoulos, Duchi and Zrnic (2023) <doi:10.48550/arXiv.2311.01453>) adapted to marginal maximum-likelihood estimation, following the mixed-subjects design of Broska, Howes and van Loon (2025) <doi:10.1177/00491241251326865>. The estimator is anchored to the human responses and is asymptotically unbiased for the human item parameters at any tuning weight; the weight on the synthetic responses is chosen to minimize propagated ability-score risk, down-weighting uninformative or biased generated responses. Louis-corrected sandwich standard errors, ability scoring, cross-fitted tuning, and scale linking are also provided.

Simulating and estimating (regime-switching) Markov chain Gaussian fields with covariance functions of the Gneiting class (Gneiting 2002) <doi:10.1198/016214502760047113>. It supports parameter estimation by weighted least squares and maximum likelihood methods, and produces Kriging forecasts and intervals for existing and new locations.

Estimation of interaction (i.e., moderation) effects between latent variables in structural equation models (SEM). The supported methods are: The constrained approach (Algina & Moulder, 2001). The unconstrained approach (Marsh et al., 2004). The residual centering approach (Little et al., 2006). The double centering approach (Lin et al., 2010). The latent moderated structural equations (LMS) approach (Klein & Moosbrugger, 2000). The quasi-maximum likelihood (QML) approach (Klein & Muthén, 2007) The constrained- unconstrained, residual- and double centering- approaches are estimated via lavaan (Rosseel, 2012), whilst the LMS- and QML- approaches are estimated via modsem it self. Alternatively model can be estimated via Mplus (Muthén & Muthén, 1998-2017). References: Algina, J., & Moulder, B. C. (2001). <doi:10.1207/S15328007SEM0801_3>. "A note on estimating the Jöreskog-Yang model for latent variable interaction using LISREL 8.3." Klein, A., & Moosbrugger, H. (2000). <doi:10.1007/BF02296338>. "Maximum likelihood estimation of latent interaction effects with the LMS method." Klein, A. G., & Muthén, B. O. (2007). <doi:10.1080/00273170701710205>. "Quasi-maximum likelihood estimation of structural equation models with multiple interaction and quadratic effects." Lin, G. C., Wen, Z., Marsh, H. W., & Lin, H. S. (2010). <doi:10.1080/10705511.2010.488999>. "Structural equation models of latent interactions: Clarification of orthogonalizing and double-mean-centering strategies." Little, T. D., Bovaird, J. A., & Widaman, K. F. (2006). <doi:10.1207/s15328007sem1304_1>. "On the merits of orthogonalizing powered and product terms: Implications for modeling interactions among latent variables." Marsh, H. W., Wen, Z., & Hau, K. T. (2004). <doi:10.1037/1082-989X.9.3.275>. "Structural equation models of latent interactions: evaluation of alternative estimation strategies and indicator construction." Muthén, L.K. and Muthén, B.O. (1998-2017). "'Mplus Userâ s Guide. Eighth Edition." <https://www.statmodel.com/>. Rosseel Y (2012). <doi:10.18637/jss.v048.i02>. "'lavaan': An R Package for Structural Equation Modeling.".

This package provides a user-friendly tool for visualizing categorical or group movement.

Market area models are used to analyze and predict store choices and market areas concerning retail and service locations. This package implements two market area models (Huff Model, Multiplicative Competitive Interaction Model) into R, while the emphases lie on 1.) fitting these models based on empirical data via OLS regression and nonlinear techniques and 2.) data preparation and processing (esp. interaction matrices and data preparation for the MCI Model).

This package provides methods for detecting signals related to (adverse event, medical product e.g. drugs, vaccines) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions. For more details please see Liu A., Mukhopadhyay R., and Markatou M. <doi:10.48550/arXiv.2410.01168>.

Package for fast computation of the maximum kernel likelihood estimator (mkle).

This package provides tools to handle, manipulate and explore trajectory data, with an emphasis on data from tracked animals. The package is designed to support large studies with several million location records and keep track of units where possible. Data import directly from movebank <https://www.movebank.org/cms/movebank-main> and files is facilitated.

This package provides functionality for estimating cross-sectional network structures representing partial correlations while accounting for missing data. Networks are estimated via neighborhood selection or regularization, with model selection guided by information criteria. Missing data can be handled primarily via multiple imputation or a maximum likelihood-based approach, as demonstrated by Nehler and Schultze (2025) <doi:10.1080/00273171.2025.2503833> and Nehler and Schultze (2026) <doi:10.1037/met0000828>. Deletion-based approaches are also available but play a secondary role.

Based on the work of Curi, Converse, Hajewski, and Oliveira (2019) <doi:10.1109/IJCNN.2019.8852333>. This package provides easy-to-use functions which create a variational autoencoder (VAE) to be used for parameter estimation in Item Response Theory (IRT) - namely the Multidimensional Logistic 2-Parameter (ML2P) model. To use a neural network as such, nontrivial modifications to the architecture must be made, such as restricting the nonzero weights in the decoder according to some binary matrix Q. The functions in this package allow for straight-forward construction, training, and evaluation so that minimal knowledge of tensorflow or keras is required.

There are three different modules: (1) model fitting and selection using a set of the most commonly used equations describing developmental responses to temperature helped by already existing R packages ('rTPC') and nonlinear regression model functions from nls.multstart (Padfield et al. 2021, <doi:10.1111/2041-210X.13585>), with visualization of model predictions to guide ecological criteria for model selection; (2) calculation of suitability thermal limits, which consist on a temperature interval delimiting the optimal performance zone or suitability; and (3) climatic data extraction and visualization inspired on previous research (Taylor et al. 2019, <doi:10.1111/1365-2664.13455>), with either exportable rasters, static map images or html, interactive maps.

This package provides graph-constrained regression methods in which regularization parameters are selected automatically via estimation of equivalent Linear Mixed Model formulation. riPEER (ridgified Partially Empirical Eigenvectors for Regression) method employs a penalty term being a linear combination of graph-originated and ridge-originated penalty terms, whose two regularization parameters are ML estimators from corresponding Linear Mixed Model solution; a graph-originated penalty term allows imposing similarity between coefficients based on graph information given whereas additional ridge-originated penalty term facilitates parameters estimation: it reduces computational issues arising from singularity in a graph-originated penalty matrix and yields plausible results in situations when graph information is not informative. riPEERc (ridgified Partially Empirical Eigenvectors for Regression with constant) method utilizes addition of a diagonal matrix multiplied by a predefined (small) scalar to handle the non-invertibility of a graph Laplacian matrix. vrPEER (variable reducted PEER) method performs variable-reduction procedure to handle the non-invertibility of a graph Laplacian matrix.

Calculate the financial impact of using a churn model in terms of cost, revenue, profit and return on investment.

In the omics data association studies, it is common to conduct the p-value corrections to control the false significance. Beyond the P-value corrections, E-value is recently studied to facilitate multiple testing correction based on V. Vovk and R. Wang (2021) <doi:10.1214/20-AOS2020>. This package provides E-value calculation for DNA methylation data and RNA-seq data. Currently, five data formats are supported: DNA methylation levels using DMR detection tools (BiSeq, DMRfinder, MethylKit, Metilene and other DNA methylation tools) and RNA-seq data. The relevant references are listed below: Katja Hebestreit and Hans-Ulrich Klein (2022) <doi:10.18129/B9.bioc.BiSeq>; Altuna Akalin et.al (2012) <doi:10.18129/B9.bioc.methylKit>.

Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework is aimed at deciphering DNA mutational signatures operating in cancer. The framework includes modules that support raw data import and processing, mutational signature extraction, and results interpretation and visualization. The framework accepts widely used file formats storing information about DNA variants, such as Variant Call Format files. The framework performs Non-Negative Matrix Factorization to extract mutational signatures explaining the observed set of DNA mutations. Bootstrapping is performed as part of the analysis. The framework supports parallelization and is optimized for use on multi-core systems. The software was described by Fantini D et al (2020) <doi:10.1038/s41598-020-75062-0> and is based on a custom R-based implementation of the original MATLAB WTSI framework by Alexandrov LB et al (2013) <doi:10.1016/j.celrep.2012.12.008>.

Given an image of a formula (typeset or handwritten) this package provides calls to the Mathpix service to produce the LaTeX code which should generate that image, and pastes it into a (e.g. an rmarkdown') document. See <https://docs.mathpix.com/> for full details. Mathpix is an external service and use of the API is subject to their terms and conditions.