Computes how the correlation between 2 time-series changes over time. To do so, the package follows the method from Choi & Shin (2021) <doi:10.1007/s42952-020-00073-6>. It performs a non-parametric kernel smoothing (using a common bandwidth) of all underlying components required for the computation of a correlation coefficient (i.e., x, y, x^2, y^2, xy). An automatic selection procedure for the bandwidth parameter is implemented. Alternative kernels can be used (Epanechnikov, box and normal). Both Pearson and Spearman correlation coefficients can be estimated and change in correlation over time can be tested.

This package provides classes and methods for trajectory data, with support for nesting individual Track objects in track sets (Tracks) and track sets for different entities in collections of Tracks. Methods include selection, generalization, aggregation, intersection, simulation, and plotting.

Computation of stopping boundaries for a single-arm trial using a Bayesian criterion. For each m<=n (n=total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety. See also Aamot et al. (2010) "Continuous monitoring of toxicity in clinical Trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.

Gives the required 2^n treatment combinations in a 2^n symmetric factorial experiment in their respective standard order.

The model, developed at the Vienna University of Technology, is a lumped conceptual rainfall-runoff model, following the structure of the HBV model. The model can also be run in a semi-distributed fashion and with dual representation of soil layer. The model runs on a daily or shorter time step and consists of a snow routine, a soil moisture routine and a flow routing routine. See Parajka, J., R. Merz, G. Bloeschl (2007) <DOI:10.1002/hyp.6253> Uncertainty and multiple objective calibration in regional water balance modelling: case study in 320 Austrian catchments, Hydrological Processes, 21, 435-446.

Tipping point analysis for clinical trials that employ Bayesian dynamic borrowing via robust meta-analytic predictive (MAP) priors. Further functions facilitate expert elicitation of a primary weight of the informative component of the robust MAP prior and computation of operating characteristics. Intended use is the planning, analysis and interpretation of extrapolation studies in pediatric drug development, but applicability is generally wider.

This package provides various commonly-used response time trimming methods, including the recursive / moving-criterion methods reported by Van Selst and Jolicoeur (1994). By passing trimming functions raw data files, the package will return trimmed data ready for inferential testing.

The functions needed to perform tight clustering Algorithm.

Facilitates development and application of two-regression algorithms for research-grade wearable devices. It provides an easy way for users to access previously-developed algorithms, and also to develop their own. Initial motivation came from Hibbing PR, LaMunion SR, Kaplan AS, & Crouter SE (2018) <doi:10.1249/MSS.0000000000001532>. However, other algorithms are now supported. Please see the associated references in the package documentation for full details of the algorithms that are supported.

This package provides an intuitive interface for working with the competing risk endpoints. The package wraps the cmprsk package, and exports functions for univariate cumulative incidence estimates and competing risk regression. Methods follow those introduced in Fine and Gray (1999) <doi:10.1002/sim.7501>.

Key-value store, implemented as a wrapper around LMDB'; the "lightning memory-mapped database" <https://www.symas.com/mdb>. LMDB is a transactional key value store that uses a memory map for efficient access. This package wraps the entire LMDB interface (except duplicated keys), and provides objects for transactions and cursors.

This package provides a modular package for simulating phylogenetic trees and species traits jointly. Trees can be simulated using modular birth-death parameters (e.g. changing starting parameters or algorithm rules). Traits can be simulated in any way designed by the user. The growth of the tree and the traits can influence each other through modifiers objects providing rules for affecting each other. Finally, events can be created to modify both the tree and the traits under specific conditions ( Guillerme, 2024 <DOI:10.1111/2041-210X.14306>).

This package provides functions to build interactive dashboards combining the Tabler UI Kit with Shiny', making it easy to create professional-looking web applications. Tabler is fully responsive and compatible with all modern browsers. Offers customizable layouts and components built with HTML5 and CSS3'. The underlying Tabler (<https://github.com/tabler/tabler>) and Tabler Icons (<https://github.com/tabler/tabler-icons>) were pre-built from source to eliminate the need for Node.js and NPM on package installation.

Evaluate inline or chunks of R code in template files and replace with their output modifying the resulting template.

Perform and Runtime statistical comparisons between models. This package aims at choosing the best model for a particular dataset, regarding its discriminant power and runtime.

Enables all rstan functionality for a TMB model object, in particular MCMC sampling and chain visualization. Sampling can be performed with or without Laplace approximation for the random effects. This is demonstrated in Monnahan & Kristensen (2018) <DOI:10.1371/journal.pone.0197954>.

Uses indicator species scores across binary partitions of a sample set to detect congruence in taxon-specific changes of abundance and occurrence frequency along an environmental gradient as evidence of an ecological community threshold. Relevant references include Baker and King (2010) <doi:10.1111/j.2041-210X.2009.00007.x>, King and Baker (2010) <doi:10.1899/09-144.1>, and Baker and King (2013) <doi:10.1899/12-142.1>.

This package implements the tail-rank statistic for selecting biomarkers from a microarray data set, an efficient nonparametric test focused on the distributional tails. See <https://gitlab.com/krcoombes/coombeslab/-/blob/master/doc/papers/tolstoy-new.pdf>.

This package provides functions for multivariate analysis with compositional data. Includes a function for doing compositional canonical correlation analysis. This analysis requires two data matrices of compositions, which can be adequately transformed and used as entries in a specialized program for canonical correlation analysis, that is able to deal with singular covariance matrices. The methodology is described in Graffelman et al. (2017) <doi:10.1101/144584>. Functions for log-ratio principal component analysis with condition number computations and log-ratio discriminant analysis have been added to the package.

Nonlinear growth models are extremely useful in gaining insight into the underlying mechanism. These models are generally mechanistic, with parameters that have biological meaning. This package allows you to fit and forecast time series data using nonlinear growth models.

This package provides a shiny based interactive exploration framework for analyzing clinical trials data. teal currently provides a dynamic filtering facility and different data viewers. teal shiny applications are built using standard shiny modules.

This package provides a reliable and validated tool that calculates unit test coverage for R packages with standard testing frameworks and non-standard testing frameworks.

This package provides a kernel of functions for programming time series methods in a way that is relatively independently of the representation of time. Also provides plotting, time windowing, and some other utility functions which are specifically intended for time series. See the Guide distributed as a vignette, or ?tframe.Intro for more details. (User utilities are in package tfplot.).

An implementation that combines trait data and a phylogenetic tree (or trees) into a single object of class treedata.table'. The resulting object can be easily manipulated to simultaneously change the trait- and tree-level sampling. Currently implemented functions allow users to use a data.table syntax when performing operations on the trait dataset within the treedata.table object. For more details see Roman-Palacios et al. (2021) <doi:10.7717/peerj.12450>.