Mixture of logistic regressions parameters (H)estimation with (U)spectral methods. The main methods take d-dimensional inputs and a vector of binary outputs, and return parameters according to the GLMs mixture model (General Linear Model). For more details see chapter 3 in the PhD thesis of Mor-Absa Loum: <https://theses.fr/s156435>, available here <https://theses.hal.science/tel-01877796/document>.

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

This package provides high-performance tools for macroeconomic trend extraction and filtering, specifically designed to solve the end-point problem in real-time. Implements the MacroBoost Hybrid (MBH) filter using penalized P-splines and gradient boosting. Unlike the standard Hodrick-Prescott filter, MacroFilters utilizes component-wise L2-boosting with robust loss functions (Huber) to handle extreme transient shocks (e.g., COVID-19) without inducing spurious trend shifts. The algorithm includes an automated two-layer diagnostic stage for unit roots and structural breaks, optimized via corrected AICc for computational efficiency. Methodology detailed in Kinel (2026) <doi:10.2139/ssrn.6371138>.

This package performs meaningful subgrouping in a meta-analysis. This is a two-step process; first, use the iterative grouping functions (e.g., mgbin(), mgcont() ) to partition studies into statistically homogeneous clusters based on their effect size data. Second, use the meaning() function to analyze these new subgroups and understand their composition based on study-level characteristics (e.g., country, setting). This approach helps to uncover hidden structures in meta-analytic data and provide a deeper interpretation of heterogeneity.

Calculate dissolved gas concentrations from raw MIMS (Membrane Inlet Mass Spectrometer) signal data. Use mimsy() on a formatted CSV file to return dissolved gas concentrations (mg and microMole) of N2, O2, Ar based on gas solubility at temperature, pressure, and salinity. See references Benson and Krause (1984), Garcia and Gordon (1992), Stull (1947), and Hamme and Emerson (2004) for more information. Easily save the output to a nicely-formatted multi-tab Excel workbook with mimsy.save(). Supports dual-temperature standard calibration for dual-bath MIMS setups.

This package provides a comprehensive set of tools for working with order statistics, including functions for simulating order statistics, censored samples (Type I and Type II), and record values from various continuous distributions. Additionally, it offers functions to compute moments (mean, variance, skewness, kurtosis) of order statistics for several continuous distributions. These tools assist researchers and statisticians in understanding and analyzing the properties of order statistics and related data. The methods and algorithms implemented in this package are based on several published works, including Ahsanullah et al (2013, ISBN:9789491216831), Arnold and Balakrishnan (2012, ISBN:1461236444), Harter and Balakrishnan (1996, ISBN:9780849394522), Balakrishnan and Sandhu (1995) <doi:10.1080/00031305.1995.10476150>, Genç (2012) <doi:10.1007/s00362-010-0320-y>, Makouei et al (2021) <doi:10.1016/j.cam.2021.113386> and Nagaraja (2013) <doi:10.1016/j.spl.2013.06.028>.

This package provides the facility to calculate non-isotropic accumulated cost surfaces, least-cost paths, least-cost corridors, least-cost networks, ranked alternative paths, cost allocation and cost boundaries, using a number of human-movement-related cost functions that can be selected by the user. The package is built around a compute-once design: a single cost surface object is created first and then reused by every analysis function, avoiding redundant computation. Visualisation is fully decoupled from computation and is provided through ggplot2 methods that can be invoked, customised, and re-invoked at any time without re-running any analysis. It just requires a Digital Terrain Model, a start location and (optionally) destination locations. See Alberti (2019) <doi:10.1016/j.softx.2019.100331>.

Utility functions for discovering and managing metadata associated with spatially unique "known locations". Applications include all fields of environmental monitoring (e.g. air and water quality) where data are collected at stationary sites.

Estimation and inference for multiple kink quantile regression for longitudinal data and the i.i.d data. A bootstrap restarting iterative segmented quantile algorithm is proposed to estimate the multiple kink quantile regression model conditional on a given number of change points. The number of kinks is also allowed to be unknown. In such case, the backward elimination algorithm and the bootstrap restarting iterative segmented quantile algorithm are combined to select the number of change points based on a quantile BIC. For longitudinal data, we also develop the GEE estimator to incorporate the within-subject correlations. A score-type based test statistic is also developed for testing the existence of kink effect. The package is based on the paper, ``Wei Zhong, Chuang Wan and Wenyang Zhang (2022). Estimation and inference for multikink quantile regression, JBES and ``Chuang Wan, Wei Zhong, Wenyang Zhang and Changliang Zou (2022). Multi-kink quantile regression for longitudinal data with application to progesterone data analysis, Biometrics".

This package provides methods for calculating and testing the significance of pairwise monotonic association from and based on the work of Pimentel (2009) <doi:10.4135/9781412985291.n2>. Computation of association of vectors from one or multiple sets can be performed in parallel thanks to the packages foreach and doMC'.

Extract cross sections from long bone meshes at specified intervals along the diaphysis. Calculate two and three-dimensional morphometric maps, cross-sectional geometric parameters, and semilandmarks on the periosteal and endosteal contours of each cross section.

Extends the mlr3 package with a backend to transparently work with databases such as SQLite', DuckDB', MySQL', MariaDB', or PostgreSQL'. The package provides three additional backends: DataBackendDplyr relies on the abstraction of package dbplyr to interact with most DBMS. DataBackendDuckDB operates on DuckDB data bases and also on Apache Parquet files. DataBackendPolars operates on Polars data frames.

This package implements analytical methods for multidimensional plant traits, including Competitors-Stress tolerators-Ruderals strategy analysis using leaf traits, Leaf-Height-Seed strategy analysis, Niche Periodicity Table analysis, and Trait Network analysis. Provides functions for data analysis, visualization, and network metrics calculation. Methods are based on He et al. (2026) <doi:10.1002/ecog.08026>.

This package implements the split-fit-evaluate-assess workflow from Hastie, Tibshirani, and Friedman (2009, ISBN:978-0-387-84857-0) "The Elements of Statistical Learning", Chapter 7. Provides three-way data splitting with automatic stratification, mandatory seeds for reproducibility, automatic data type handling, and 10 algorithms out of the box. Uses Rust backend for cross-language deterministic splitting. Designed for tabular supervised learning with minimal ceremony. Polyglot parity with the Python mlw package on PyPI'.

Two distinct but related statistical approaches to the problem of identifying the combinations of medication error characteristics that are more likely to result in harm are implemented in this package: 1) a Bayesian hierarchical model with optimal Bayesian ranking on the log odds of harm, and 2) an empirical Bayes model that estimates the ratio of the observed count of harm to the count that would be expected if error characteristics and harm were independent. In addition, for the Bayesian hierarchical model, the package provides functions to assess the sensitivity of results to different specifications of the random effects distributions.

Transforms, calculates, and presents results from the Mental Health Quality of Life Questionnaire (MHQoL), a measure of health-related quality of life for individuals with mental health conditions. Provides scoring functions, summary statistics, and visualization tools to facilitate interpretation. For more details see van Krugten et al.(2022) <doi:10.1007/s11136-021-02935-w>.

The target of margaret is help to extract data from Minciencias to analyze scientific production in Colombia.

This package provides functions to access drug regulatory data from public RESTful APIs including the FDA Open API and the Health Canada Drug Product Database API', retrieving real-time or historical information on drug approvals, adverse events, recalls, and product details. Additionally, the package includes a curated collection of open datasets focused on drugs, pharmaceuticals, treatments, and clinical studies. These datasets cover diverse topics such as treatment dosages, pharmacological studies, placebo effects, drug reactions, misuses of pain relievers, and vaccine effectiveness. The package supports reproducible research and teaching in pharmacology, medicine, and healthcare by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: FDA API <https://open.fda.gov/apis/> and Health Canada API <https://health-products.canada.ca/api/documentation/dpd-documentation-en.html>.

The stepwise regression with assumptions checking and the possible Box-Cox transformation.

Includes support for Mapbox Navigation APIs, including directions, isochrones, and route optimization; the Search API for forward and reverse geocoding; the Maps API for interacting with Mapbox vector tilesets and visualizing Mapbox maps in R; and Mapbox Tiling Service and tippecanoe for generating map tiles. See <https://docs.mapbox.com/api/> for more information about the Mapbox APIs.

Following the common types of measures of uncertainty for parameter estimation, two measures of uncertainty were proposed for model selection, see Liu, Li and Jiang (2020) <doi:10.1007/s11749-020-00737-9>. The first measure is a kind of model confidence set that relates to the variation of model selection, called Mac. The second measure focuses on error of model selection, called LogP. They are all computed via bootstrapping. This package provides functions to compute these two measures. Furthermore, a similar model confidence set adapted from Bayesian Model Averaging can also be computed using this package.

Flexible and informed regression with Multiple Change Points. mcp can infer change points in means, variances, autocorrelation structure, and any combination of these, as well as the parameters of the segments in between. All parameters are estimated with uncertainty and prediction intervals are supported - also near the change points. mcp supports hypothesis testing via Savage-Dickey density ratio, posterior contrasts, and cross-validation. mcp is described in Lindeløv (submitted) <doi:10.31219/osf.io/fzqxv> and generalizes the approach described in Carlin, Gelfand, & Smith (1992) <doi:10.2307/2347570> and Stephens (1994) <doi:10.2307/2986119>.

Estimates probit, logit, Poisson, negative binomial, and beta regression models, returning their marginal effects, odds ratios, or incidence rate ratios as an output. Greene (2008, pp. 780-7) provides a textbook introduction to this topic.

This package provides a fast, flexible machine learning library, written in C++, that aims to provide fast, extensible implementations of cutting-edge machine learning algorithms. See also Curtin et al. (2023) <doi:10.21105/joss.05026>.