Abstract of Manuscript. Differential gene expression analysis using RNA sequencing (RNA-seq) data is a standard approach for making biological discoveries. Ongoing large-scale efforts to process and normalize publicly available gene expression data enable rapid and systematic reanalysis. While several powerful tools systematically process RNA-seq data, enabling their reanalysis, few resources systematically recompute differentially expressed genes (DEGs) generated from individual studies. We developed a robust differential expression analysis pipeline to recompute 3162 human DEG lists from The Cancer Genome Atlas, Genotype-Tissue Expression Consortium, and 142 studies within the Sequence Read Archive. After measuring the accuracy of the recomputed DEG lists, we built the Differential Expression Enrichment Tool (DEET), which enables users to interact with the recomputed DEG lists. DEET, available through CRAN and RShiny, systematically queries which of the recomputed DEG lists share similar genes, pathways, and TF targets to their own gene lists. DEET identifies relevant studies based on shared results with the userâ s gene lists, aiding in hypothesis generation and data-driven literature review. Sokolowski, Dustin J., et al. "Differential Expression Enrichment Tool (DEET): an interactive atlas of human differential gene expression." Nucleic Acids Research Genomics and Bioinformatics (2023).

Parse, format, and validate international phone numbers using Google's libphonenumber java library, <https://github.com/google/libphonenumber>.

This package provides a dimension reduction technique for outlier detection. DOBIN: a Distance based Outlier BasIs using Neighbours, constructs a set of basis vectors for outlier detection. This is not an outlier detection method; rather it is a pre-processing method for outlier detection. It brings outliers to the fore-front using fewer basis vectors (Kandanaarachchi, Hyndman 2020) <doi:10.1080/10618600.2020.1807353>.

To overcome the memory limitations for fitting linear (LM) and Generalized Linear Models (GLMs) to large data sets, this package implements the Divide and Recombine (D&R) strategy. It basically divides the entire large data set into suitable subsets manageable in size and then fits model to each subset. Finally, results from each subset are aggregated to obtain the final estimate. This package also supports fitting GLMs to data sets that cannot fit into memory and provides methods for fitting GLMs under linear regression, binomial regression, Poisson regression, and multinomial logistic regression settings. Respective models are fitted using different D&R strategies as described by: Xi, Lin, and Chen (2009) <doi:10.1109/TKDE.2008.186>, Xi, Lin and Chen (2006) <doi:10.1109/TKDE.2006.196>, Zuo and Li (2018) <doi:10.4236/ojs.2018.81003>, Karim, M.R., Islam, M.A. (2019) <doi:10.1007/978-981-13-9776-9>.

This package performs differential network analysis to infer disease specific gene networks.

Simulates and computes the (maximum) likelihood of a dynamical model of island biota assembly through speciation, immigration and extinction. See Valente et al. (2015) <doi:10.1111/ele.12461>.

Models for analyzing site occupancy and count data models with detection error, including single-visit based models (Lele et al. 2012 <doi:10.1093/jpe/rtr042>, Moreno et al. 2010 <doi:10.1890/09-1073.1>, Solymos et al. 2012 <doi:10.1002/env.1149>, Denes et al. 2016 <doi:10.1111/1365-2664.12818>), conditional distance sampling and time-removal models (QPAD) (Solymos et al. 2013 <doi:10.1111/2041-210X.12106>, Solymos et al. 2018 <doi:10.1650/CONDOR-18-32.1>), and single bin QPAD (SQPAD) models (Lele & Solymos 2025). Package development was supported by the Alberta Biodiversity Monitoring Institute and the Boreal Avian Modelling Project.

This package provides functions that offer seamless D3Plus integration. The examples provided here are taken from the official D3Plus website <http://d3plus.org>.

CRAN packages DoE.base and Rmosek and non-'CRAN package gurobi are enhanced with functionality for the creation of optimized arrays for experimentation, where optimization is in terms of generalized minimum aberration. It is also possible to optimally extend existing arrays to larger run size. The package writes MPS (Mathematical Programming System) files for use with any mixed integer optimization software that can process such files. If at least one of the commercial products Gurobi or Mosek (free academic licenses available for both) is available, the package also creates arrays by optimization. For installing Gurobi and its R package gurobi', follow instructions at <https://support.gurobi.com/hc/en-us/articles/14462206790033-How-do-I-install-Gurobi-for-R>. For installing Mosek and its R package Rmosek', follow instructions at <https://www.mosek.com/downloads/> and <https://docs.mosek.com/8.1/rmosek/install-interface.html>, or use the functionality in the stump CRAN R package Rmosek'.

Allows manual creation of themes and logos to be used in applications created using the shinydashboard package. Removes the need to change the underlying css code by wrapping it into a set of convenient R functions.

Nonparametric kernel density estimation, bandwidth selection, and other utilities for analyzing directional data. Implements the estimator in Bai, Rao and Zhao (1987) <doi:10.1016/0047-259X(88)90113-3>, the cross-validation bandwidth selectors in Hall, Watson and Cabrera (1987) <doi:10.1093/biomet/74.4.751> and the plug-in bandwidth selectors in Garcà a-Portugués (2013) <doi:10.1214/13-ejs821>.

Piecewise linear segmentation of ordered data by a dynamic programming algorithm. The algorithm was developed for time series data, e.g. growth curves, and for genome-wide read-count data from next generation sequencing, but is broadly applicable. Generic implementations of dynamic programming routines allow to scan for optimal segmentation parameters and test custom segmentation criteria ("scoring functions").

This package performs calculations with tree taper (or stem profile) equations, including model fitting. The package implements the methods from Garcà a, O. (2015) "Dynamic modelling of tree form" <http://mcfns.net/index.php/Journal/article/view/MCFNS7.1_2>. The models are parsimonious, describe well the tree bole shape over its full length, and are consistent with wood formation mechanisms through time.

This package provides a drop-in replacement for dplyr', powered by DuckDB for performance. Offers convenient utilities for working with in-memory and larger-than-memory data while retaining full dplyr compatibility.

Reverse and model the effects of changing deposition rates on geological data and rates. Based on Hohmann (2018) <doi:10.13140/RG.2.2.23372.51841> .

This package provides a library of density, distribution function, quantile function, (bounded) raw moments and random generation for a collection of distributions relevant for the firm size literature. Additionally, the package contains tools to fit these distributions using maximum likelihood and evaluate these distributions based on (i) log-likelihood ratio and (ii) deviations between the empirical and parametrically implied moments of the distributions. We add flexibility by allowing the considered distributions to be combined into piecewise composite or finite mixture distributions, as well as to be used when truncated. See Dewitte (2020) <https://hdl.handle.net/1854/LU-8644700> for a description and application of methods available in this package.

Visualizes variables from descriptive tables produced by descsuppR::buildDescrTbl() using ggstatsplot'. It automatically maps each variable to a suitable ggstatsplot plotting function based on the applied or suggested statistical test. Users can override the automatic mapping via a named list of plot specifications. The package supports grouped and ungrouped tables, and forwards additional arguments to the underlying ggstatsplot functions, providing quick, reproducible, and customizable default visualizations for descriptive summaries.

This package provides functions for demographic analysis including lifetable calculations; Lee-Carter modelling; functional data analysis of mortality rates, fertility rates, net migration numbers; and stochastic population forecasting.

Programmatic access to the DuckDuckGo Instant Answer API <https://api.duckduckgo.com/api>.

This package provides a disk-based data manipulation tool for working with large-than-RAM datasets. Aims to lower the barrier-to-entry for manipulating large datasets by adhering closely to popular and familiar data manipulation paradigms like dplyr verbs and data.table syntax.

Simple Principal Components Analysis (PCA) and (Multiple) Correspondence Analysis (CA) based on the Singular Value Decomposition (SVD). This package provides S4 classes and methods to compute, extract, summarize and visualize results of multivariate data analysis. It also includes methods for partial bootstrap validation described in Greenacre (1984, ISBN: 978-0-12-299050-2) and Lebart et al. (2006, ISBN: 978-2-10-049616-7).

Classical Test and Item analysis, Item Response analysis and data management for educational and psychological tests.

Companion to the book "An Introduction to Clustering with R" by P. Giordani, M.B. Ferraro and F. Martella (Springer, Singapore, 2020). The datasets are used in some case studies throughout the text.

Toggles the test and production versions of a large data analysis project.