This package provides a collection of functions for calculating the M2 model fit statistic for diagnostic classification models as described by Liu et al. (2016) <DOI:10.3102/1076998615621293>. These functions provide multiple sources of information for model fit according to the M2 statistic, including the M2 statistic, the *p* value for that M2 statistic, and the Root Mean Square Error of Approximation based on the M2 statistic.

This package provides a collection of methods for quantifying the similarity of two or more datasets, many of which can be used for two- or k-sample testing. It provides newly implemented methods as well as wrapper functions for existing methods that enable calling many different methods in a unified framework. The methods were selected from the review and comparison of Stolte et al. (2024) <doi:10.1214/24-SS149>.

Estimation of incidence and case fatality for a chronic disease, given partial information, using a multi-state model. Given data on age-specific mortality and either incidence or prevalence, Bayesian inference is used to estimate the posterior distributions of incidence, case fatality, and functions of these such as prevalence. The methods are described in Jackson et al. (2023) <doi:10.1093/jrsssa/qnac015>.

The desirable Dietary Pattern (DDP)/ PPH score measures the variety of food consumption. The (weighted) score is calculated based on the type of food. This package is intended to calculate the DDP/ PPH score that is faster than traditional method via a manual calculation by BKP (2017) <http://bkp.pertanian.go.id/storage/app/uploads/public/5bf/ca9/06b/5bfca906bc654274163456.pdf> and is simpler than the nutrition survey <http://www.nutrisurvey.de>. The database to create weights and baseline values is the Indonesia national survey in 2017.

This package provides utilities to calculate the probabilities of various dice-rolling events, such as the probability of rolling a four-sided die six times and getting a 4, a 3, and either a 1 or 2 among the six rolls (in any order); the probability of rolling two six-sided dice three times and getting a 10 on the first roll, followed by a 4 on the second roll, followed by anything but a 7 on the third roll; or the probabilities of each possible sum of rolling five six-sided dice, dropping the lowest two rolls, and summing the remaining dice.

Managing postgraduate programmes involves extracting information from Lattes CVs. This information can be used for strategic planning and self-evaluation, as well as for producing reports on the Sucupira Platform. Summary reports are produced for each period and course (specialisation, master's and doctorate), showing bibliographic production with and without student participation, as well as papers at events, technical or technological production, ongoing and completed supervision, research projects, exchanges (visiting professor, postdoctoral or short-term leave), awards and general activity indicators. Based on this information, a detailed report is then drawn up for each lecturer, taking into account their participation in exam boards, their research project contributions, their technical collaborations (e.g. advisory committee, editorial board) and the subjects they teach. For more details see Pagliosa and Nascimento (2021) <https://repositorio.ufsc.br/bitstream/handle/123456789/231602/ManualLattesGeociencias11_2021_versaobeta%20%281%29.pdf?sequence=1&isAllowed=y>.

This package provides methods for testing the equality between groups of estimated density functions. The package implements FDET (Fourier-based Density Equality Testing) and MDET (Moment-based Density Equality Testing), two new approaches introduced by the author. Both methods extend an earlier testing approach by Delicado (2007), "Functional k-sample problem when data are density functions" <doi:10.1007/s00180-007-0047-y>, which is referred to as DET (Density Equality Testing) in this package for clarity. FDET compares groups of densities based on their global shape using Fourier transforms, while MDET tests for differences in distributional moments. All methods are described in Anarat, Krutmann and Schwender (2025), "Testing for Differences in Extrinsic Skin Aging Based on Density Functions" (Submitted).

This package provides Python-based extensions to enhance data analytics workflows, particularly for tasks involving data preprocessing and predictive modeling. Includes tools for data sampling, transformation, feature selection, balancing strategies (e.g., SMOTE), and model construction. These capabilities leverage Python libraries via the reticulate interface, enabling seamless integration with a broader machine learning ecosystem. Supports instance selection and hybrid workflows that combine R and Python functionalities for flexible and reproducible analytical pipelines. The architecture is inspired by the Experiment Lines approach, which promotes modularity, extensibility, and interoperability across tools. More information on Experiment Lines is available in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

Works as a virtual CRAN snapshot for source packages. It automatically downloads and installs tar.gz files with dependencies, all of which were available on a specific day.

Distributed Online Goodness-of-Fit Test can process the distributed datasets. The philosophy of the package is described in Guo G.(2024) <doi:10.1016/j.apm.2024.115709>.

This package provides a systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Low level functions for implementing maximum likelihood estimating procedures for complex models using data cloning and Bayesian Markov chain Monte Carlo methods as described in Solymos 2010 <doi:10.32614/RJ-2010-011>. Sequential and parallel MCMC support for JAGS', WinBUGS', OpenBUGS', and Stan'.

Set of tools aimed at processing meteorological data, converting hourly recorded data to daily, monthly and annual data.

Estimation, validation and prediction of models of different types : linear models, additive models, MARS,PolyMARS and Kriging.

This package provides the user with an interactive application which can be used to facilitate the planning of dose finding studies by applying the theory of optimal experimental design.

Intelligently assign samples to batches in order to reduce batch effects. Batch effects can have a significant impact on data analysis, especially when the assignment of samples to batches coincides with the contrast groups being studied. By defining a batch container and a scoring function that reflects the contrasts, this package allows users to assign samples in a way that minimizes the potential impact of batch effects on the comparison of interest. Among other functionality, we provide an implementation for OSAT score by Yan et al. (2012, <doi:10.1186/1471-2164-13-689>).

Data whitening is a widely used preprocessing step to remove correlation structure since statistical models often assume independence. Here we use a probabilistic model of the observed data to apply a whitening transformation. This Gaussian Inverse Wishart Empirical Bayes model substantially reduces computational complexity, and regularizes the eigen-values of the sample covariance matrix to improve out-of-sample performance.

This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

This package provides tools to help the design and analysis of resilient non-inferiority trials. These include functions for sample size calculations and analyses of trials, with either a risk difference, risk ratio or arc-sine difference margin, and a function to run simulations to design a trial with the methods described in Quartagno et al. (2019) <arXiv:1905.00241>.

This package provides mean squared error (MSE) and plot the kernel densities related to extreme value distributions with their estimated values. By using Gumbel and Weibull Kernel. See Salha et al. (2014) <doi:10.4236/ojs.2014.48061> and Khan and Akbar (2021) <doi:10.4236/ojs.2021.112018 >.

This tool is for parsing public drug databases such as DrugBank XML database <https://go.drugbank.com/>. The parsed data are then returned in a proper R object called dvobject'.

This package provides R-implementation of Decision forest algorithm, which combines the predictions of multiple independent decision tree models for a consensus decision. In particular, Decision Forest is a novel pattern-recognition method which can be used to analyze: (1) DNA microarray data; (2) Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) data; and (3) Structure-Activity Relation (SAR) data. In this package, three fundamental functions are provided, as (1)DF_train, (2)DF_pred, and (3)DF_CV. run Dforest() to see more instructions. Weida Tong (2003) <doi:10.1021/ci020058s>.

Calculate and analyze ecological connectivity across the watercourse of river networks using the Dendritic Connectivity Index.

Seasonal- and calendar adjustment of time series with daily frequency using the DSA approach developed by Ollech, Daniel (2018): Seasonal adjustment of daily time series. Bundesbank Discussion Paper 41/2018.