This package implements the conditionally symmetric multidimensional Gaussian mixture model (csmGmm) for large-scale testing of composite null hypotheses in genetic association applications such as mediation analysis, pleiotropy analysis, and replication analysis. In such analyses, we typically have J sets of K test statistics where K is a small number (e.g. 2 or 3) and J is large (e.g. 1 million). For each one of the J sets, we want to know if we can reject all K individual nulls. Please see the vignette for a quickstart guide. The paper describing these methods is "Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies" by Sun R, McCaw Z, & Lin X (Journal of the American Statistical Association 2025, <doi:10.1080/01621459.2024.2422124>).

Synthesizing joint distributions from marginal densities, focusing on controlling key statistical properties such as correlation for continuous data, mutual information for categorical data, and inducing Simpson's Paradox. Generate datasets with specified correlation structures for continuous variables, adjust mutual information between categorical variables, and manipulate subgroup correlations to intentionally create Simpson's Paradox. Joe (1997) <doi:10.1201/b13150> Sklar (1959) <https://en.wikipedia.org/wiki/Sklar%27s_theorem>.

Responsive and modern HTML card essentials for shiny applications and dashboards. This novel card component in Bootstrap provides a flexible and extensible content container with multiple variants and options for building robust R based apps e.g for graph build or machine learning projects. The features rely on a combination of JQuery <https://jquery.com> and CSS styles to improve the card functionality.

Various tools for inferring causal models from observational data. The package includes an implementation of the temporal Peter-Clark (TPC) algorithm. Petersen, Osler and Ekstrøm (2021) <doi:10.1093/aje/kwab087>. It also includes general tools for evaluating differences in adjacency matrices, which can be used for evaluating performance of causal discovery procedures.

This package provides classes (S4) of commonly used elliptical, Archimedean, extreme-value and other copula families, as well as their rotations, mixtures and asymmetrizations. Nested Archimedean copulas, related tools and special functions. Methods for density, distribution, random number generation, bivariate dependence measures, Rosenblatt transform, Kendall distribution function, perspective and contour plots. Fitting of copula models with potentially partly fixed parameters, including standard errors. Serial independence tests, copula specification tests (independence, exchangeability, radial symmetry, extreme-value dependence, goodness-of-fit) and model selection based on cross-validation. Empirical copula, smoothed versions, and non-parametric estimators of the Pickands dependence function.

Implementations of threshold regression approaches for linear regression models with a covariate subject to random censoring, including deletion threshold regression and completion threshold regression. Reverse survival regression, which flip the role of response variable and the covariate, is also considered.

Bindings to qpdf': qpdf (<https://qpdf.sourceforge.io/>) is a an open-source PDF rendering library that allows to conduct content-preserving transformations of PDF files such as split, combine, and compress PDF files.

Classical cryptography methods for words and brief phrases. Substitution, transposition and concealment (null) ciphers are available, like Caesar, Vigenère, Atbash, affine, simple substitution, Playfair, rail fence, Scytale, single column, bifid, trifid, and Polybius ciphers.

The Large Language Model (LLM) represents a groundbreaking advancement in data science and programming, and also allows us to extend the world of R. A seamless interface for integrating the OpenAI Web APIs into R is provided in this package. This package leverages LLM-based AI techniques, enabling efficient knowledge discovery and data analysis. The previous functions such as seamless translation and image generation have been moved to other packages deepRstudio and stableDiffusion4R'.

This package provides a set of utilities for matching products in different classification codes used in international trade research. It supports concordance between the Harmonized System (HS0, HS1, HS2, HS3, HS4, HS5, HS combined), the Standard International Trade Classification (SITC1, SITC2, SITC3, SITC4), the North American Industry Classification System (NAICS combined), as well as the Broad Economic Categories (BEC), the International Standard of Industrial Classification (ISIC), and the Standard Industrial Classification (SIC). It also provides code nomenclature/descriptions look-up, Rauch classification look-up (via concordance to SITC2), and trade elasticity look-up (via concordance to HS0 or SITC3 codes).

This package implements a modern, unified estimation strategy for common mediation estimands (natural effects, organic effects, interventional effects, and recanting twins) in combination with modified treatment policies as described in Liu, Williams, Rudolph, and DÃ az (2024) <doi:10.48550/arXiv.2408.14620>. Estimation makes use of recent advancements in Riesz-learning to estimate a set of required nuisance parameters with deep learning. The result is the capability to estimate mediation effects with binary, categorical, continuous, or multivariate exposures with high-dimensional mediators and mediator-outcome confounders using machine learning.

This package provides a set of state-of-the-art probabilistic modeling approaches to derive estimates of individual customer lifetime values (CLV). Commonly, probabilistic approaches focus on modelling 3 processes, i.e. individuals attrition, transaction, and spending process. Latent customer attrition models, which are also known as "buy-'til-you-die models", model the attrition as well as the transaction process. They are used to make inferences and predictions about transactional patterns of individual customers such as their future purchase behavior. Moreover, these models have also been used to predict individualsâ long-term engagement in activities such as playing an online game or posting to a social media platform. The spending process is usually modelled by a separate probabilistic model. Combining these results yields in lifetime values estimates for individual customers. This package includes fast and accurate implementations of various probabilistic models for non-contractual settings (e.g., grocery purchases or hotel visits). All implementations support time-invariant covariates, which can be used to control for e.g., socio-demographics. If such an extension has been proposed in literature, we further provide the possibility to control for time-varying covariates to control for e.g., seasonal patterns. Currently, the package includes the following latent attrition models to model individuals attrition and transaction process: [1] Pareto/NBD model (Pareto/Negative-Binomial-Distribution), [2] the Extended Pareto/NBD model (Pareto/Negative-Binomial-Distribution with time-varying covariates), [3] the BG/NBD model (Beta-Gamma/Negative-Binomial-Distribution) and the [4] GGom/NBD (Gamma-Gompertz/Negative-Binomial-Distribution). Further, we provide an implementation of the Gamma/Gamma model to model the spending process of individuals.

Learning the structure of graphical models from datasets with thousands of variables. More information about the research papers detailing the theory behind Chordalysis is available at <http://www.francois-petitjean.com/Research> (KDD 2016, SDM 2015, ICDM 2014, ICDM 2013). The R package development site is <https://github.com/HerrmannM/Monash-ChoR>.

Obtain coordinate system metadata from various data formats. There are functions to extract a CRS (coordinate reference system, <https://en.wikipedia.org/wiki/Spatial_reference_system>) in EPSG (European Petroleum Survey Group, <http://www.epsg.org/>), PROJ4 <https://proj.org/>, or WKT2 (Well-Known Text 2, <http://docs.opengeospatial.org/is/12-063r5/12-063r5.html>) forms. This is purely for getting simple metadata from in-memory formats, please use other tools for out of memory data sources.

This package implements the algorithm described in Trapnell,C. et al. (2010) <doi: 10.1038/nbt.1621>. This function takes read counts matrix of RNA-Seq data, feature lengths which can be retrieved using biomaRt package, and the mean fragment lengths which can be calculated using the CollectInsertSizeMetrics(Picard) tool. It then returns a matrix of FPKM normalised data by library size and feature effective length. It also provides the user with a quick and reliable function to generate FPKM heatmap plot of the highly variable features in RNA-Seq dataset.

This package provides functions for efficient computation of non-linear spatial predictions with local change of support (Hofer, C. and Papritz, A. (2011) "constrainedKriging: An R-package for customary, constrained and covariance-matching constrained point or block kriging" <doi:10.1016/j.cageo.2011.02.009>). This package supplies functions for two-dimensional spatial interpolation by constrained (Cressie, N. (1993) "Aggregation in geostatistical problems" <doi:10.1007/978-94-011-1739-5_3>), covariance-matching constrained (Aldworth, J. and Cressie, N. (2003) "Prediction of nonlinear spatial functionals" <doi:10.1016/S0378-3758(02)00321-X>) and universal (external drift) Kriging for points or blocks of any shape from data with a non-stationary mean function and an isotropic weakly stationary covariance function. The linear spatial interpolation methods, constrained and covariance-matching constrained Kriging, provide approximately unbiased prediction for non-linear target values under change of support. This package extends the range of tools for spatial predictions available in R and provides an alternative to conditional simulation for non-linear spatial prediction problems with local change of support.

Reads Word documents containing incomplete bibliographic references and produces an updated file with standardized and complete references. The package provides functions to retrieve missing authors, titles, journal details, volume, issue, and page numbers. Digital object identifiers (DOIs) are retrieved using the CrossRef application programming interface (API) <https://api.crossref.org>, and references are formatted following DOI-based citation standards as described by Paskin (2010) <doi:10.1000/182> and the citation.doi.org service <https://citation.doi.org>. The package is intended to simplify reference preparation for scientific journal submissions.

Employs a two-parameter family of distributions for modelling random variables on the (0, 1) interval by applying the cumulative distribution function (cdf) of one parent distribution to the quantile function of another.

Covariance is of universal prevalence across various disciplines within statistics. We provide a rich collection of geometric and inferential tools for convenient analysis of covariance structures, topics including distance measures, mean covariance estimator, covariance hypothesis test for one-sample and two-sample cases, and covariance estimation. For an introduction to covariance in multivariate statistical analysis, see Schervish (1987) <doi:10.1214/ss/1177013111>.

Direct sparse covariance matrix estimation via the covariance graphical lasso by Bien, Tibshirani (2011) <doi:10.1093/biomet/asr054> using the fast coordinate descent algorithm of Wang (2014) <doi:10.1007/s11222-013-9385-5>.

Computing elliptical joint confidence regions at a specified confidence level. It provides the flexibility to estimate either classical or robust confidence regions, which can be visualized in 2D or 3D plots. The classical approach assumes normality and uses the mean and covariance matrix to define the confidence regions. Alternatively, the robustified version employs estimators like minimum covariance determinant (MCD) and M-estimator, making them less sensitive to outliers and departures from normality. Furthermore, the functions allow users to group the dataset based on categorical variables and estimate separate confidence regions for each group. This capability is particularly useful for exploring potential differences or similarities across subgroups within a dataset. Varmuza and Filzmoser (2009, ISBN:978-1-4200-5947-2). Johnson and Wichern (2007, ISBN:0-13-187715-1). Raymaekers and Rousseeuw (2019) <DOI:10.1080/00401706.2019.1677270>.

Apply and visualize conditional formatting to data frames in R. It renders a data frame with cells formatted according to criteria defined by rules, using a tidy evaluation syntax. The table is printed either opening a web browser or within the RStudio viewer if available. The conditional formatting rules allow to highlight cells matching a condition or add a gradient background to a given column. This package supports both HTML and LaTeX outputs in knitr reports, and exporting to an xlsx file.

Compute ranking and rating based on competition results. Methods of different nature are implemented: with fixed Head-to-Head structure, with variable Head-to-Head structure and with iterative nature. All algorithms are taken from the book Whoâ s #1?: The science of rating and ranking by Amy N. Langville and Carl D. Meyer (2012, ISBN:978-0-691-15422-0).

Measures morphological diversity from discrete character data and estimates evolutionary tempo on phylogenetic trees. Imports morphological data from #NEXUS (Maddison et al. (1997) <doi:10.1093/sysbio/46.4.590>) format with read_nexus_matrix(), and writes to both #NEXUS and TNT format (Goloboff et al. (2008) <doi:10.1111/j.1096-0031.2008.00217.x>). Main functions are test_rates(), which implements AIC and likelihood ratio tests for discrete character rates introduced across Lloyd et al. (2012) <doi:10.1111/j.1558-5646.2011.01460.x>, Brusatte et al. (2014) <doi:10.1016/j.cub.2014.08.034>, Close et al. (2015) <doi:10.1016/j.cub.2015.06.047>, and Lloyd (2016) <doi:10.1111/bij.12746>, and calculate_morphological_distances(), which implements multiple discrete character distance metrics from Gower (1971) <doi:10.2307/2528823>, Wills (1998) <doi:10.1006/bijl.1998.0255>, Lloyd (2016) <doi:10.1111/bij.12746>, and Hopkins and St John (2018) <doi:10.1098/rspb.2018.1784>. This also includes the GED correction from Lehmann et al. (2019) <doi:10.1111/pala.12430>. Multiple functions implement morphospace plots: plot_chronophylomorphospace() implements Sakamoto and Ruta (2012) <doi:10.1371/journal.pone.0039752>, plot_morphospace() implements Wills et al. (1994) <doi:10.1017/S009483730001263X>, plot_changes_on_tree() implements Wang and Lloyd (2016) <doi:10.1098/rspb.2016.0214>, and plot_morphospace_stack() implements Foote (1993) <doi:10.1017/S0094837300015864>. Other functions include safe_taxonomic_reduction(), which implements Wilkinson (1995) <doi:10.1093/sysbio/44.4.501>, map_dollo_changes() implements the Dollo stochastic character mapping of Tarver et al. (2018) <doi:10.1093/gbe/evy096>, and estimate_ancestral_states() implements the ancestral state options of Lloyd (2018) <doi:10.1111/pala.12380>. calculate_tree_length() and reconstruct_ancestral_states() implements the generalised algorithms from Swofford and Maddison (1992; no doi).